Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis

Queiroz, Salomão Israel Monteiro Lourenço; Silva, Marcus Vinícius Amarante da; Medeiros, Ana Miryam Costa de; Oliveira, Patrícia Teixeira de; Gurgel, Bruno César de Vasconcelos; Silveira, Éricka Janine Dantas da

doi:10.1590/abd1806-4841.20186228

Cited by 52 publications

(39 citation statements)

References 17 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is a small number of studies in which patients were diagnosed by direct detection of present lesions by a practitioner. Queiroz et al [22] A similar negative correlation between smoking and RAS was noticed in our study. The treatment and, many times, the diagnosis of RAS are a challenge in the daily life of the clinician.…”

Section: Original Articlessupporting

confidence: 91%

Smoking and Recurrent Aphthous Stomatitis

Obradović¹,

Igić²,

Mitić³

et al. 2019

EDUJ

View full text Add to dashboard Cite

Introduction: Recurrent aphthous stomatitis (RAS) is one of the most usual inflammatory diseases of the oral mucosa. The clinical characteristics of RAS are well defined, but the exact etiology and pathogenesis of the disease are not. Several investigations have noticed cigarette smoking to have a protective effect on RAS. The aim of the study is to investigate the association between cigarette smoking and RAS in order to improve the current knowledge on this issue. Methodology: 68 patients with RAS participated in the study. A full mouth clinical examination was performed and a medical history was taken for each patient. Data were analyzed with χ 2 test. Results: While 6 (8.9%) of patients with RAS were smokers, a significantly higher percentage (24.9%) among the subjects with RAS were not smokers (group II) (χ2 =70.4; d.f. = 2, P < 0.001). Conclusion: The negative association between smoking and RAS indicated by this investigation is not meant to encourage people to smoke nor to spare them from the intention to quit their habit. These conclusions should be used to clear up the cause and pathogenesis of the RAS and to identify better prevention and treatment.

show abstract

Section: Original Articlessupporting

confidence: 91%

Smoking and Recurrent Aphthous Stomatitis

Obradović¹,

Igić²,

Mitić³

et al. 2019

EDUJ

View full text Add to dashboard Cite

show abstract

“…This high prevalence in women can be explained by thefact that women seek more medical attention. 7 Although several etiologic factors have been proposed, the exact causes of recurrent aphthous stomatitis are still not very clear. Previous studies of tissue infiltrated mononuclear cells in recurrent aphthous stomatitis specimens favor the role of cellmediated cytotoxicity in its immunopathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Recurrent Aphthous Stomatitis With Iron Deficiency Anemia

Nurdiana

Astari

2018

Dentika Dental J.

View full text Add to dashboard Cite

Recurrent aphtous stomatitisis a recurrent oral ulcer. Clinically recurrent aphtous stomatitis is easy to diagnose, but its etiology and pathogenesis remain unclear because it has no single or specific cause. The main predisposing factors associated with recurrent aphtous stomatitis are genetic factors, hematological and immunologic abnormalities, local factors such as trauma, and smoking cessation. Several studies have shown that hematological abnormalities can affect the oral mucosa and cause recurrent aphtous stomatitis. The purpose of this study was to examine the relationship between recurrent aphthous stomatitis and iron deficiency anemia, as well as the relationship between recurrent aphthous stomatitis and hematological status. The subjects consist of 59 recurrent aphtous stomatitis patients and 60 control patients. A full blood examination was carried out for all subjects. Hemoglobin level, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and serum iron level are determined for each subject.The result of this study showed that there is no significant difference in hemoglobin level, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and serum iron level with p-value of 0.714, 0.395, 0.809, 0.497, and 0.368, respectively. The result also showed that there is no significant difference in iron deficiency anemia status between the recurrent aphtous stomatitis and control group (p = 0,7). Therefore, it can be concluded that there is no relationship between iron deficiency anemia and recurrent aphtous stomatitis incidence.

show abstract

“…Recurrent aphthous stomatitis (RAS) is an inflammatory condition resulting in painful ulcerations on the oropharyngeal mucosa, and is thought to affect approximately 1.6% of the general population. [168] Three studies reported prevalence of RAS among individuals with SIgAD, finding values from 1.2% to 4.9%, with a weighted average of 2.4%. [20,28,128] (Table 24) However, RAS is associated with other autoimmune disorders including Celiac disease and inflammatory bowel disease, and may be a manifestation of these diseases in some cases.…”

Section: Recurrent Aphthous Stomatitismentioning

confidence: 99%

“…[20,28,128] (Table 24) However, RAS is associated with other autoimmune disorders including Celiac disease and inflammatory bowel disease, and may be a manifestation of these diseases in some cases. [168] Without controlling for these disease entities, it is impossible to determine whether RAS has a separate correlation with SIgAD.…”

Section: Recurrent Aphthous Stomatitismentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

View full text Add to dashboard Cite

Selective Immunoglobulin A Deficiency (SIgAD) is the most common primary immunodeficiency, defined as an isolated deficiency of IgA (less than 0.07 g/L). Although the majority of people born with IgA deficiency lead normal lives without significant pathology, there is nonetheless a significant association of IgA deficiency with mucosal infection, increased risks of atopic disease, and a higher prevalence of autoimmune disease. To explain these phenomena, we have performed an extensive literature review to define the geoepidemiology of IgA deficiency and particularly the relative risks for developing Systemic Lupus Erythematosus, hyperthyroidism, hypothyroidism, type 1 diabetes mellitus, Crohn's Disease, ulcerative colitis, rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and vitiligo; these diseases have strong data to support an association. We also note weaker associations with scleroderma, celiac disease, autoimmune hepatitis, immune thrombocytopenic purpura, and autoimmune hemolytic anemia. Minimal if any associations are noted with myasthenia gravis, lichen planus, and multiple sclerosis. Finally, more recent data provide clues on the possible immunologic mechanisms that lead to the association of IgA deficiency and autoimmunity; these lessons are important for understanding the etiology of autoimmune disease. 2 3 Introduction:

show abstract

Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis

Cited by 52 publications

References 17 publications

Smoking and Recurrent Aphthous Stomatitis

Smoking and Recurrent Aphthous Stomatitis

Relationship Between Recurrent Aphthous Stomatitis With Iron Deficiency Anemia

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Contact Info

Product

Resources

About