Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study

Linhartová, Petra Bořilová; Jánoš, Július; Slezaková, Simona; Bártová, Jiřina; Petanová, Jitka; Kuklı́nek, Pavel; Fassmann, Antonín; Dušek, Ladislav; Hollá, Lýdie Izakovičová

doi:10.1111/eos.12577

Cited by 12 publications

(7 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several cytokines that are linked with RAS pathogenesis have also been studied, however there were no confirmatory observations on those cytokines in RAS. Clinical studies that focused on estimation of cytokine levels in RAS are interferon and Interleukins, such as IFN [34,35], IL-8 [36], IL-1β [37][38][39][40], IL-1 [35,41,42], IL-2 [34,[43][44][45][46], IL-4 [44,45,47,48], IL-6 [37,42,46,49], 45,[50][51][52][53], IL-12 [50,51], IL-13 [35,45], IL-17 [35,54], IL-17C [55], IL-17F [56]. Unfortunately, these findings on cytokines were not able to achieve any clinically reliable application in RAS while comparing TNF-α.…”

Section: Discussionmentioning

confidence: 99%

The expression of TNF-α in recurrent aphthous stomatitis: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

The expression of TNF-α in recurrent aphthous stomatitis: A systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

“…Kalpana et al identified increased salivary levels of IL-2 in patients with RAS [132], while other researchers did not reveal significant differences between serum levels of IL-2 in patients with RAS, compared to controls [132][133][134][135]. The explanation for these differences is not very clear.…”

Section: Relationships Between Fa and Recurrent Aphthous Stomatitismentioning

confidence: 93%

Folic Acid and Its Role in Oral Health: A Narrative Review

et al. 2023

View full text Add to dashboard Cite

Vitamins, exogenous organic compounds that play a vital role in metabolic reactions, and fundamental powerful antioxidants with a crucial role in the genetic transcription process, are considered essential nutritional factors. Folic acid (FA), also known as folate, or Vitamin B9, plays an indispensable role in various intracellular reactions, being the main pawn, with a strong impact on medical and dental science. The aim of this paper mainly focuses on presenting the latest and most advanced aspects related to the following topics: (1) the resonance that FA, and more specifically FA deficiency, has at the level of the oral cavity; (2) the elements involved in the molecular landscape, which reflect the interaction and the possible mechanisms of action, through which FA influences oral health; and (3) the particular processes by which FA deficiency causes certain clinical conditions. Moreover, we aim to draw the attention and trigger the curiosity of health professionals on the need to know the specific host–environment interactions, particularly the linkage between individual genotype and phenotypic variability, which in the future could represent the basis of novel and effective treatment methods. From this perspective, we begin by providing an overview of the general radar echo of the human body induced by FA deficiency, before focusing on the genetic strategic substrate and biochemical processes involved in the molecular mechanisms through which FA acts at the cellular level. Finally, we reflect on the resulting conclusions: (1) the complex interrelationships between different types of cytokines (CKs) and abnormal folate metabolism are involved in the occurrence of neural tube defects (NTDs) and orofacial clefts (OFCs); (2) increased oxidative stress, endothelial dysfunction, and genomic instability, induced by folate deficiency, have a major impact on periodontal health; and (3) glutamate carboxypeptidase II, GCP2 1561C>T allelic variant, constitutes the main pawn, which specifically influences the bioavailability of natural folates and FA, as the main actors, with essential roles in oral health.

show abstract

“…To test this hypothesis and to limit any confounding bias (latitude, etc. ), we focused on the countries whose IL‐6 gene polymorphisms at rs1800796 and rs1800795 loci, IL‐6R gene polymorphism at rs2228145 locus, IL‐10 gene polymorphism at rs1800896 and rs1800871 loci, IL‐17A gene polymorphism at rs2275913 and IL‐17F gene polymorphism at rs763780 loci were defined and the allele frequencies were reported in 54 studies 10–63 . We searched the literature for the interleukin gene polymorphisms determined in the populations of China, Japan, India, Spain, Mexico, Sweden, Turkey, Brazil, Russia, Poland, Italy, South Africa, Netherlands, Greece, Germany, UK, Iran, Finland, Czechia, Tunisia, Norway, Egypt, Croatia.…”

Section: Methodsmentioning

confidence: 99%

Correlation between interleukin gene polymorphisms and current prevalence and mortality rates due to novel coronavirus disease 2019 (COVID‐2019) in 23 countries

Batur

Hekim

2021

Journal of Medical Virology

View full text Add to dashboard Cite

Background The novel coronavirus disease 2019 (COVID‐19) infection may rely on a potential genetic background for the variations in the inflammatory response. We aimed to investigate the possible correlation between polymorphisms in the IL‐6 gene at rs1800796/rs1800795, in IL‐6R at rs2228145, in IL‐10 at rs1800896 and rs1800871, in IL‐17 at rs2275913 and rs763780 loci, and COVID‐19 prevalence and mortality rates among populations of 23 countries. Methods We searched the literature for polymorphisms in China, Japan, India, Spain, Mexico, Sweden, Turkey, Brazil, Russia, Poland, Italy, South Africa, Netherlands, Greece, Germany, UK, Iran, Finland, Czechia, Tunisia, Norway, Egypt, Croatia. We recorded the prevalence and mortality rates (per million) caused by the Coronavirus infection recorded on 7th September 2020 and 6th December 2020. Results There was a significant positive correlation between the frequency of AG genotype of rs1800896 and prevalence recorded on 6th December 2020 ( r : 0.53, r 2 : 0.28, p < .05). There was a significant negative correlation between the mortality rates recorded on 7th September, and the AG genotype of rs2275913 ( r : −0.51, r 2 : 0.26, p < .05). There was a significant positive correlation between the prevalence recorded on 6th December, and TT genotype at rs763780 ( r : 0.65, r 2 :0.42, p < .05) while a negative correlation between prevalence and TC genotype at rs763780 ( r : −0.66, r 2 : 0.43, p < .05). Also, a significant negative correlation was found between mortality rates recorded on 6th December 2020 and CC genotype at rs763780 ( r : −0.56, r 2 : 0.31, p < .05). Conclusion The variations in prevalence of COVID‐19 and its mortality rates among countries may be explained by the polymorphisms at rs1800896 in IL‐10 , rs2275913 in IL‐17A , and rs763780 loci in the IL‐17F gene.

show abstract

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study

Cited by 12 publications

References 56 publications

The expression of TNF-α in recurrent aphthous stomatitis: A systematic review and meta-analysis

The expression of TNF-α in recurrent aphthous stomatitis: A systematic review and meta-analysis

Folic Acid and Its Role in Oral Health: A Narrative Review

Correlation between interleukin gene polymorphisms and current prevalence and mortality rates due to novel coronavirus disease 2019 (COVID‐2019) in 23 countries

Contact Info

Product

Resources

About