The expression of TNF-α in recurrent aphthous stomatitis: A systematic review and meta-analysis

Surboyo, Meircurius Dwi Condro; Boedi, Rizky Merdietio; Hariyani, Ninuk; Santosh, Arvind Babu Rajendra; Manuaba, Ida Bagus Pramana Putra; Cecilia, Pamela Handy; Ambarawati, I Gusti Agung Dyah; Parmadiati, Adiastuti Endah; Ernawati, Diah Savitri

doi:10.1016/j.cyto.2022.155946

Cited by 9 publications

(5 citation statements)

References 58 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the occurrence and recovery of oral ulcers, a large number of cytokines and chemokines, such as TNF-α, IL-1β, IL-6, and IL-8, were involved in the regulation of inflammatory response and affect the process of oral ulcers. Among these inflammatory factors, TNF-α and IL-6 play a leading role [ 40 , 41 , 42 , 43 ]. Therefore, macrophages (RAW 264.7) were incubated in diluents of 3J or different hydrogels after inflammation induction with Lipopolysaccharide, and the levels of TNF-α and IL-6 were used as evaluation indexes to investigate their anti-inflammatory effects.…”

Section: Resultsmentioning

confidence: 99%

Carboxymethyl Chitosan/Sodium Alginate/Chitosan Quaternary Ammonium Salt Composite Hydrogel Supported 3J for the Treatment of Oral Ulcer

Lin

Chen

Geng

et al. 2023

Gels

View full text Add to dashboard Cite

Oral ulcer is a common inflammatory disease of oral mucosa, causing severe burning pain and great inconvenience to daily life. In this study, compound 3J with anti-inflammatory activity was synthesized beforehand. Following that, an intelligent composite hydrogel supported 3J was designed with sodium alginate, carboxymethyl chitosan, and chitosan quaternary ammonium salt as the skeleton, and its therapeutic effect on the rat oral ulcer model was investigated. The results show that the composite hydrogel has a dense honeycomb structure, which is conducive to drug loading and wound ventilation, and has biodegradability. It has certain antibacterial effects and good anti-inflammatory activity. When loaded with 3J, it reduced levels of TNF-α and IL-6 in inflammatory cells by up to 50.0%. It has excellent swelling and water retention properties, with a swelling rate of up to 765.0% in a pH 8.5 environment. The existence of a large number of quaternary ammonium groups, carboxyl groups, and hydroxyl groups makes it show obvious differences in swelling in different pH environments, which proves that it has double pH sensitivity. It is beneficial to adapt to the highly dynamic changes of the oral environment. Compared with single hydrogel or drug treatment, the drug-loaded hydrogel has a better effect on the treatment of oral ulcers.

show abstract

Section: Resultsmentioning

confidence: 99%

Carboxymethyl Chitosan/Sodium Alginate/Chitosan Quaternary Ammonium Salt Composite Hydrogel Supported 3J for the Treatment of Oral Ulcer

Lin

Chen

Geng

et al. 2023

Gels

View full text Add to dashboard Cite

show abstract

“…In healthy individuals, TNFα is significantly lower than RAS. [ 23 ] The pathogenesis of RAS is associated with an increase in the pro-inflammatory cytokine TNFα. This cytokine plays an important role in the development of ulcerative lesions.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology-based strategy combined with molecular docking to explore the potential mechanism of agarwood against recurrent aphthous stomatitis

Tao,

Zhang,

Yuan

et al. 2024

Medicine

View full text Add to dashboard Cite

To explore the antiinflammatory mechanism of agarwood on recurrent aphthous stomatitis (RAS). RAS is the most common mucosal disease in the oral cavity. The clinical application of traditional Chinese medicine found that agarwood has significant curative effect on peptic ulcer, but the effect and mechanism of agarwood on RAS remain unclear. This study is intended to predict the potential antiinflammatory mechanisms by which agarwood acts on RAS through network pharmacology and molecular docking. TCMSP database was used to screen the active components of agarwood. RAS targets were screened in Genecards, DisGeNET, and OMIM database. Venny, an online tool, screens for interacting genes between the two. Cytoscape software was used to construct the gene regulation map of active compounds target of agarwood. String Database building protein-protein interaction network. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathways were enriched in DAVID database. The key active ingredients and core targets were further verified by molecular docking. There were 9 effective compounds and 186 target genes in agarwood; RAS has 793 target genes. There were 41 interacting genes between agarwood and RAS. Interleukin 6, tumor necrosis factor, interleukin 1 beta, and cellular component motif ligand 2 may be key targets. Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses predicted multiple pathways associated with RAS. Molecular docking results showed that the active compounds of agarwood combined well and stably with the target. The Chinese herbal medicine agarwood can relieve the inflammation of RAS through multiple targets and various ways. Its active compounds may be nominated as candidates for antiinflammatory drugs of RAS.

show abstract

“… 18 TNF-α is a cytokine produced by monocytes, macrophages, mast cells, etc., and its excessive release is the specific process of ulcer disease. Moreover, TNF-α plays a variety of important roles in regulating immune active cells and enhancing the immune function of the body, 19 such as promoting the secretion of pro-inflammatory factors such as IL-2 and CRP and the release of chemokines such as oxygen free radicals and enhancing the degree of inflammation and oxidative stress response in the body. Also, its mediated inflammatory response can lead to tissue lysis, edema and rupture and other damage to the oral mucosa, with its level positively correlated with the severity of the patient’s condition.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of recombinant human basic fibroblast growth factor combined with ranitidine in the treatment of recurrent oral ulcer and its effect on serum TNF, IL-2 and T-lymphocyte subsets

Chen,

Liu,

Sun

2024

Pak J Med Sci

View full text Add to dashboard Cite

Objective: To evaluate the clinical efficacy of recombinant human basic fibroblast growth factor (rh-bFGF) combined with ranitidine in the treatment of recurrent oral ulcer and its effects on serum TNF, IL-2 and T-lymphocyte subsets. Methods: This was a retrospective study. Eighty patients with oral ulcers admitted to First Medical Center, Chinese PLA General Hospital from July 2021 to June 2022 were randomly divided into the control group and the experimental group (n=40). Patients in the control group were given topical treatment with rh-bFGF gel, while those in the experimental group were given oral treatment combined with ranitidine based on the control group, and both groups were treated continuously for 14 days. The therapeutic effect, pain relief time, ulcer healing time, as well as the differences in the levels of inflammatory factors and T-lymphocyte subsets were compared and analyzed between the two groups. Results: The overall response rate of the experimental group was 92.5%, while that of the control group was 75%, with a statistically significant difference(P=0.03). After treatment, inflammatory factors indexes in the experimental group were significantly lower than those in the control group, with statistically significant differences (P=0.00). The indexes of T-lymphocyte subsets in the experimental group were significantly higher than those in the control group after treatment, with statistically significant differences (P=0.00). Conclusion: Recombinant human basic fibroblast growth factor combined with ranitidine is effective in the treatment of recurrent oral ulcers, boasting various benefits such as effectively promoting ulcer healing, reducing pain and inflammatory response, and enhancing immune function. doi: https://doi.org/10.12669/pjms.40.4.7881 How to cite this: Chen P, Liu B, Sun H. Clinical efficacy of recombinant human basic fibroblast growth factor combined with ranitidine in the treatment of recurrent oral ulcer and its effect on serum TNF, IL-2 and T-lymphocyte subsets. Pak J Med Sci. 2024;40(4):679-684. doi: https://doi.org/ 10.12669/pjms.40.4.7881 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

The expression of TNF-α in recurrent aphthous stomatitis: A systematic review and meta-analysis

Cited by 9 publications

References 58 publications

Carboxymethyl Chitosan/Sodium Alginate/Chitosan Quaternary Ammonium Salt Composite Hydrogel Supported 3J for the Treatment of Oral Ulcer

Carboxymethyl Chitosan/Sodium Alginate/Chitosan Quaternary Ammonium Salt Composite Hydrogel Supported 3J for the Treatment of Oral Ulcer

Network pharmacology-based strategy combined with molecular docking to explore the potential mechanism of agarwood against recurrent aphthous stomatitis

Clinical efficacy of recombinant human basic fibroblast growth factor combined with ranitidine in the treatment of recurrent oral ulcer and its effect on serum TNF, IL-2 and T-lymphocyte subsets

Contact Info

Product

Resources

About