Recurrent anaphylaxis due to pigeon tick bites

Schlosser, Rhea; Meißner, Markus; Kaufmann, Roland; Valesky, Eva Maria

doi:10.1111/ddg.13739

Cited by 4 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The response to ectoparasite bites varies from no reaction to a local reaction at the bite site or a generalized anaphylactic reaction (Castelli et al 2008;Okahashi et al 2015;Cabezas-Cruz et al 2015;Mateos-Hernández et al 2017;Jackson, 2018;Schlosser et al 2019). Tick bites trigger a humoral immune response in infested individuals, but allergic reactions to tick bites involve, among others, symptoms of the AGS that are associated with anti-α-Gal IgE levels (Mateos-Hernández et al 2017;Hodžić et al 2019;Mateo-Borrega et al 2019).…”

Section: Humoral Immune Response To Mite Proteins and α-Galmentioning

confidence: 99%

Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae)

Lima-Barbero¹,

Sánchez‐Sánchez²,

Cabezas-Cruz³

et al. 2019

Exp Appl Acarol

View full text Add to dashboard Cite

Blood-feeding ectoparasites constitute a growing burden for human and animal health, and animal production worldwide. In particular, mites (Acari: Gamasida) of the genera 2 Dermanyssus (Dermanyssidae) and Ornithonyssus (Macronyssidae) infest birds and cause gamasoidosis in humans. The tropical fowl mite, Ornithonyssus bursa, is commonly found in tropical and subtropical countries but rarely reported in Europe. In this research we characterized the first two cases in Spain of clinical gamasoidosis diagnosed in patients infested with O. bursa, and investigated the IgE, IgM and IgG antibody response to mite proteins and the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) involved in the tick-bite associated alpha-Gal syndrome (AGS). The results suggested that O. bursa is establishing across Mediterranean countries, and may increase the risk for gamasoidosis. The immune antibody response to mite proteins was higher for IgM and similar for IgE and IgG antibodies between patients and non-allergic control individuals exposed to mite or tick bites. The anti-α-Gal antibody levels were similar between patients and controls, a result supported by the absence of this carbohydrate in mites. These results suggested that mite bites do not correlate with antibody response to acarine proteins or α-Gal, and are not associated with the AGS.

show abstract

Section: Humoral Immune Response To Mite Proteins and α-Galmentioning

confidence: 99%

Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae)

Lima-Barbero¹,

Sánchez‐Sánchez²,

Cabezas-Cruz³

et al. 2019

Exp Appl Acarol

View full text Add to dashboard Cite

show abstract

“…Tick bites could induce anaphylaxis in susceptible patients with a history of tick bites. 2,8,9 Actually, more than half of the patients with tick anaphylaxis have a history of tick allergy, and some of the involved allergens have been identified in tick saliva. Furthermore, some patients with tick anaphylaxis have a history of bee anaphylaxis.…”

Section: Discussionmentioning

confidence: 99%

Tick anaphylaxis triggered by pulling out the tick

Takayama¹,

Takagaki²

2020

Acute Medicine & Surgery

View full text Add to dashboard Cite

Background: Reports of tick anaphylaxis are extremely rare in Asian countries, with poor awareness in these regions. Herein, we report a case of tick anaphylaxis that was triggered by pulling out the tick. Case Presentation: A 66-year-old man developed pruritus in his left toes after returning from a mountain. Three days later, he found a swollen tick biting at the skin between the second and third toes and pulled it out. Approximately 30 min after pulling out the tick, he started to feel a burning sensation in his chest and was brought to our hospital. He was diagnosed with anaphylactic shock (systolic blood pressure, 60 mmHg) and immediately received intramuscular adrenaline. Conclusion: To our knowledge, this is the first case of tick anaphylaxis triggered by tick removal in an Asian country. A tick should be removed without pressure on its body, especially in patients with tick or bee allergy.

show abstract

“…In any case, ticks can trigger the pathological specific immune responses by secretion of α‐Gal in saliva (detected in the lone star tick, Amblyomma americanum , and Ixodes holocyclus ) [56]. Of course, humans can also develop allergies to salivary components of other ticks, for example, the soft tick Argas reflexus (pigeon tick) [57]. The development of pruritus in people who have been bitten repeatedly by Ixodes correlates significantly with decreased likelihood of transmission of Borrelia burgdorferi [58].…”

Section: Feeding and Salivary Secretionmentioning

confidence: 99%

The tick and I: Parasite‐host interactions between ticks and humans

Schön

2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Ticks, particularly hard ticks (Ixodidae), which are among the most important vectors of dangerous infectious agents, feed on their hosts for extended periods of time. With this lifestyle, numerous adaptations have evolved in ticks and their hosts, the pharmacological importance of which is increasingly being recognized. Many bioactive substances in tick saliva are being considered as the basis of new drugs. For example, components of tick cement can be developed into tissue adhesives or wound closures. Analgesic and antipruritic salivary components inhibit histamine or bradykinin, while other tick‐derived molecules bind opioid or cannabinoid receptors. Tick saliva inhibits the extrinsic, intrinsic, or common pathway of blood coagulation with implications for the treatment of thromboembolic diseases. It contains vasodilating substances and affects wound healing. The broad spectrum of immunomodulatory and immunosuppressive effects of tick saliva, such as inhibition of chemokines or cellular immune responses, allows development of drugs against inflammation in autoimmune diseases and/or infections. Finally, modern vaccines against ticks can curb the spread of serious infections. The medical importance of the complex tick‐host interactions is increasingly being recognized and translated into first clinical applications. Using selected examples, an overview of the mutual adaptations of ticks and hosts is given here, focusing on their significance to medical advance.

show abstract

Recurrent anaphylaxis due to pigeon tick bites

Cited by 4 publications

References 4 publications

Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae)

Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae)

Tick anaphylaxis triggered by pulling out the tick

The tick and I: Parasite‐host interactions between ticks and humans

Contact Info

Product

Resources

About