Recurrence Rates After DCE-MRI Image Guided Planning for Breast-conserving Surgery Following Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Patients

Partridge, SC

doi:10.1016/s1043-321x(08)80064-1

Cited by 3 publications

(4 citation statements)

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“…Furthermore, MR has long been prohibitively expensive for routine use and there is a need for a low-cost equivalent alternative. Yet, for high-risk women, MRI is now viewed as the gold standard for breast cancer detection and screening [15][16][17][18][19][20][21][22][23]. Positron emission tomography is also limited by cost and radiation concerns.…”

Section: The Breast Screening Challengementioning

confidence: 99%

Breast Ultrasound Tomography

Duric¹,

Littrup²

2018

Breast Imaging

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Both mammography and standard ultrasound (US) rely upon subjective criteria within the breast imaging reporting and data system (BI-RADS) to provide more uniform interpretation outcomes, as well as differentiation and risk stratification of associated abnormalities. In addition, the technical performance and professional interpretation of both tests suffer from machine and operator dependence. We have been developing a new technique for breast imaging that is based on ultrasound tomography which quantifies tissue characteristics while also producing 3-D images of breast anatomy. Results are presented from clinical studies that utilize this method. In the first phase of the study, ultrasound tomography (UST) images were compared to multi-modal imaging to determine the appearance of lesions and breast parenchyma. In the second phase, correlative comparisons with MR breast imaging were used to establish basic operational capabilities of the UST system. The third phase of the study focused on lesion characterization. Region of interest (ROI) analysis was used to characterize masses. Our study demonstrated a high degree of correlation of breast tissue structures relative to fat subtracted contrastenhanced MRI and the ability to scan ~90% of the volume of the breast at a resolution of 0.7 mm in the coronal plane.

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Section: The Breast Screening Challengementioning

confidence: 99%

Breast Ultrasound Tomography

Duric¹,

Littrup²

2018

Breast Imaging

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“…Studies have shown that MR can have a positive impact in the breast management continuum ranging from risk assessment to diagnosis and treatment monitoring. [8][9][10][11][12][13][14][15][16][17][18] However, MR requires long exam times and intravenous contrast agents. Furthermore, MR has long been prohibitively expensive for routine use and there is a need for an equivalent low-cost alternative.…”

Section: Introductionmentioning

confidence: 99%

Breast imaging with the SoftVue imaging system: first results

et al. 2013

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For women with dense breast tissue, who are at much higher risk for developing breast cancer, the performance of mammography is at its worst. Consequently, many early cancers go undetected when they are the most treatable. Improved cancer detection for women with dense breasts would decrease the proportion of breast cancers diagnosed at later stages, which would significantly lower the mortality rate. The emergence of whole breast ultrasound provides good performance for women with dense breast tissue, and may eliminate the current trade-off between the cost effectiveness of mammography and the imaging performance of more expensive systems such as magnetic resonance imaging.We report on the performance of SoftVue, a whole breast ultrasound imaging system, based on the principles of ultrasound tomography. SoftVue was developed by Delphinus Medical Technologies and builds on an early prototype developed at the Karmanos Cancer Institute. We present results from preliminary testing of the SoftVue system, performed both in the lab and in the clinic. These tests aimed to validate the expected improvements in image performance. Initial qualitative analyses showed major improvements in image quality, thereby validating the new imaging system design. Specifically, SoftVue's imaging performance was consistent across all breast density categories and had much better resolution and contrast. The implications of these results for clinical breast imaging are discussed and future work is described.

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“…Accurate and frequent evaluation of a tumor's response to therapy is needed in order to minimize side effects, optimize treatment and plan for surgery. [12][13][14][15][16][17][18][19][20][21] Some patients exhibit complete pathological remission from receiving neoadjuvant chemotherapy (no cancer cells at time of surgery). Predicting such response early in the process may not only help reduce the duration of the chemotherapy and thereby obviate the morbidity associated with it in community breast cancer treatment, but also provide a reliable pharmacodynamic endpoint to assess or compare the clinical efficacy of a new therapeutic agent or regimen versus treatment approach under standard care.…”

Section: Introductionmentioning

confidence: 99%

“…This has effectively made MRI the "gold standard" for breast imaging, but is too costly and has too limited access in the community to be used as a general screening tool. Nevertheless, several recent articles confirm that dynamic contrast enhanced (DCE) MRI remains very useful as both a prognostic tool before treatment, as well as measuring response to chemotherapy [12][13][14][15][16][17][18][19][20][21] . MRI again becomes the emerging gold standard, but with a high price that becomes prohibitive for repeating several exams during the course of chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

et al. 2010

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The purpose of this study was to correlate changes in biomechanical properties of breast cancer lesions in response to neoadjuvant chemotherapy. Nine patients were examined repeatedly throughout their treatment, using an experimental prototype based on the principles of ultrasound tomography. The study was HIPAA compliant, approved by the Institutional Review Board, and performed after obtaining the requisite informed consent. Images of reflection, sound speed and attenuation, representing the entire volume of the breast, were reconstructed from the exam data and analyzed for time-dependent changes during the treatment period. It was found that changes in tumor properties could be measured in all cases. Furthermore, changes in sound speed were found to vary strongly from patient to patient. A comparison of the sound speed response curves with pathological findings suggests that complete responders exhibit distinctly different responses as measured by sound speed. These preliminary results were used to define a cut-point for predicting response. Subsequently, a prospective prediction of the treatment response of a new patient was made correctly. We hypothesize that changes in the biomechanical properties of breast cancers, as measured by sound speed, can predict response. Future studies will focus on testing this hypothesis and defining and quantifying markers of response.

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Recurrence Rates After DCE-MRI Image Guided Planning for Breast-conserving Surgery Following Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer Patients

Cited by 3 publications

References 0 publications

Breast Ultrasound Tomography

Breast Ultrasound Tomography

Breast imaging with the SoftVue imaging system: first results

Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

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