Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

Lupinacci, Jessica; Duric, Nebojsa; Littrup, Peter J.; Wang, Ding; Li, Cuiping; Schmidt, Steven; Ranger, Bryan J.; West, Erik; Szczepanski, Amy; Rama, Olsi; Bey-Knight, Lisa; Myc, Lukasz

doi:10.1117/12.845647

Cited by 5 publications

(5 citation statements)

References 37 publications

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“…This could potentially reduce the number of false-positive biopsies as well as the number of falsely down-staged lesions. Similarly to what has already been shown for US by Sannachi et al 50 and for SoS US by Lupinacci et al, 51 SoS-US could potentially be used as a fast and easy tool to predict the tumor response to chemotherapy. The current resolution is too low to make a conclusive statement on inner lesion structure.…”

Section: Discussionmentioning

confidence: 54%

Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections

et al. 2019

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The aim of this study was to differentiate malignant and benign solid breast lesions with a novel ultrasound (US) technique, which measures speed of sound (SoS) using standard US transducers and intrinsic tissue reflections and scattering (speckles) as internal reference. MATERIALS AND METHODS This prospective, institutional review board-approved, Health Insurance Portability and Accountability Act-compliant prospective comparison study was performed with prior written informed consent from 20 women. Ten women with histological proven breast cancer and 10 with fibroadenoma were measured. A conventional US system with a linear probe was used for SoS-US (SonixTouch; Ultrasonix, Richmond, British Columbia, Canada). Tissue speckle reflections served as a timing reference for the US signals transmitted through the breasts. Relative phase inconsistencies were detected using plane wave measurements from different angular directions, and SoS images with 0.5-mm resolution were generated using a spatial domain reconstruction algorithm. The SoS of tumors were compared with the breast density of a larger cohort of 106 healthy women. RESULTS Breast lesions show focal increments ΔSoS (meters per second) with respect to the tissue background. Peak ΔSoS values were evaluated. Breast carcinoma showed significantly higher ΔSoS than fibroadenomas ([INCREMENT]SoS > 41.64 m/s: sensitivity, 90%; specificity, 80%; area under curve, 0.910) and healthy breast tissue of different densities (area under curve, 0.938; sensitivity, 90%; specificity, 96.5%). The lesion localization in SoS-US images was consistent with B-mode imaging and repeated SoS-US measurements were reproducible. CONCLUSIONS Using SoS-US, based on conventional US and tissue speckles as timing reference, breast carcinoma showed significantly higher SoS values than fibroadenoma and healthy breast tissue of different densities. The SoS presents a promising technique for differentiating solid breast lesions.

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Section: Discussionmentioning

confidence: 54%

Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections

et al. 2019

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“…This study builds on previous work that was based on lower-quality sound speed images reconstructed from a simpler algorithm (29). While the earlier study also demonstrated the ability to monitor changes in and V and VASS, it did not yield statistically significant differences between the complete and partial responders.…”

Section: Discussionmentioning

confidence: 73%

“…The images and data were collected during the period March 23, 2007 to June 17, 2011. An early UST prototype (27) of the SoftVue system (Delphinus Medical Technologies, Novi, MI) was used in the original data collection, which included 21 patients (29). The current study represents a new analysis of the data using a new high-resolution reconstruction algorithm (30).…”

Section: Data Collectionmentioning

confidence: 99%

“…Ultrasound tomography (UST) (22)(23)(24)(25)(26)(27)(28)(29)(30) is an emerging technology that, like MRI, provides automated, operator independent, full volumetric views of the breast but, unlike MRI, is fast (2-4 minute exams) and does not require contrast. Previous studies have shown that the speed of sound, determined from UST, can accurately quantify the density of breast tissue (31)(32)(33) and tumor volume (29,30). Such quantification would represent an advance in treatment monitoring beyond the current standard of care where tumor size changes are observed by standard imaging (e.g.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Marker, Based on Ultrasound Tomography, for Monitoring Early Response to Neoadjuvant Chemotherapy

Duric

Littrup

Sak

et al. 2020

Journal of Breast Imaging

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Objective To evaluate the combination of tumor volume and sound speed as a potential imaging marker for assessing neoadjuvant chemotherapy (NAC) response. Methods This study was carried out under an IRB-approved protocol (written consent required). Fourteen patients undergoing NAC for invasive breast cancer were examined with ultrasound tomography (UST) throughout their treatment. The volume (V) and the volume-averaged sound speed (VASS) of the tumors and their changes were measured for each patient. Time-dependent response curves of V and VASS were constructed individually for each patient and then as averages for the complete versus partial response groups in order to characterize differences between the two groups. Differences in group means were assessed for statistical significance using t-tests. Differences in shapes of group curves were evaluated with Kolmogorov–Smirnoff tests. Results On average, tumor volume and sound speed in the partial response group showed a gradual decline in the first 60 days of treatment, while the complete response group showed a much steeper decline (P < 0.05). The shapes of the response curves of the two groups, corresponding to the entire treatment period, were also found to be significantly different (P < 0.05). Furthermore, large simultaneous drops in volume and sound speed in the first 3 weeks of treatment were characteristic only of the complete responders (P < 0.05). Conclusions This study demonstrates the feasibility of using UST to monitor NAC response, warranting future studies to better define the potential of UST for noninvasive, rapid identification of partial versus complete responders in women undergoing NAC.

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“…SoftVue was developed by Delphinus Medical Technologies (DMT), and is based on an early prototype [27][28][29][30][31][32][33] developed at the Karmanos Cancer Institute (KCI). The SoftVue imaging system was designed to provide enhanced performance relative to the prototype.…”

Section: Introductionmentioning

confidence: 99%

Breast imaging with the SoftVue imaging system: first results

et al. 2013

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For women with dense breast tissue, who are at much higher risk for developing breast cancer, the performance of mammography is at its worst. Consequently, many early cancers go undetected when they are the most treatable. Improved cancer detection for women with dense breasts would decrease the proportion of breast cancers diagnosed at later stages, which would significantly lower the mortality rate. The emergence of whole breast ultrasound provides good performance for women with dense breast tissue, and may eliminate the current trade-off between the cost effectiveness of mammography and the imaging performance of more expensive systems such as magnetic resonance imaging.We report on the performance of SoftVue, a whole breast ultrasound imaging system, based on the principles of ultrasound tomography. SoftVue was developed by Delphinus Medical Technologies and builds on an early prototype developed at the Karmanos Cancer Institute. We present results from preliminary testing of the SoftVue system, performed both in the lab and in the clinic. These tests aimed to validate the expected improvements in image performance. Initial qualitative analyses showed major improvements in image quality, thereby validating the new imaging system design. Specifically, SoftVue's imaging performance was consistent across all breast density categories and had much better resolution and contrast. The implications of these results for clinical breast imaging are discussed and future work is described.

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Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

Cited by 5 publications

References 37 publications

Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections

Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections

A Novel Marker, Based on Ultrasound Tomography, for Monitoring Early Response to Neoadjuvant Chemotherapy

Breast imaging with the SoftVue imaging system: first results

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