Recurrence Patterns and Survival for Patients With Intermediate- and High-Grade Myxofibrosarcoma

Haglund, K.E.; Raut, Chandrajit P.; Nascimento, Alessandra F.; Wang, Qian; George, Suzanne; Baldini, Elizabeth H.

doi:10.1016/j.ijrobp.2010.08.042

Cited by 98 publications

(95 citation statements)

References 30 publications

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“…MFSs have a better survival rate than other types of sarcoma [30]. At a median follow-up of 3.5 years, the local recurrence was 31%, and metastasis occurred in 17% of the patients [16]. Lung, bone and lymph nodes are preferential sites of metastases [36].…”

Section: Discussionmentioning

confidence: 99%

Primary renal myxofibrosarcoma

Val-Bernal

García-González

Mayorga

et al. 2015

Pathology - Research and Practice

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Section: Discussionmentioning

confidence: 99%

Primary renal myxofibrosarcoma

Val-Bernal

García-González

Mayorga

et al. 2015

Pathology - Research and Practice

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“…8,10 Recent retrospective cohorts of MFS reported a 5-year local recurrence rate of 18–31 % and an associated overall survival (OS) of approximately 70 %. 7,11,12 Tumor size at resection, tumor grade, positive surgical resection margin, percent necrosis, and mitotic rate have all been suggested as possible prognostic factors for disease-specific and metastasis-free survival, but these studies have been hampered by their small size and heterogeneous treatments. 11-13 …”

mentioning

confidence: 99%

Prognostic Factors and Outcomes of Patients with Myxofibrosarcoma

et al. 2012

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Background Myxofibrosarcomas (MFS) are a historically heterogeneous group of tumors that exhibit a propensity for local recurrence. The objectives of this study were to analyze the prognostic factors and outcomes of patients with MFS treated at a single institution. Methods We retrospectively reviewed the records of 69 consecutive patients with pathologically confirmed MFS of the extremities or superficial trunk who underwent surgery from August 1995 to November 2010. Clinicopathologic features, treatments, and patient outcomes were reviewed. Results Sixty-nine patients were identified, of whom 38 were men (55 %). The median age was 62 years. Sixty-four patients (93 %) presented with primary tumors, and 5 patients (7 %) presented with locally recurrent tumors. Median tumor size was 6.0 cm, and 44 patients (64 %) had grade 3 tumors (FNCLCC [Fédération Nationale des Centres de Lutte Contre le Cancer] classification). Margins were microscopically positive in 14 patients (20 %) and negative in 55 patients (80 %), including close margins (<1 mm) in 14 patients (20 %). Fifty-three patients (77 %) received radiotherapy. At a median follow-up of 41 months, there were 11 local (16 %) and 11 distant (16 %) recurrences. The local and distant 5-year recurrence-free survival rates were 72 % and 82 %, and the 5-year overall survival was 61 %. Increased age (scaled by 0.1; hazard ratio [HR] 1.80, P = 0.002) and tumor size (HR 1.12, P = 0.004) were negatively correlated with overall survival. Positive/close (<1 mm) margin status (HR 4.34, P = 0.030) predicted worsened local recurrence-free survival. Conclusions MFS exhibit a propensity for local recurrence, which is predicted by resection with positive or close margins. Aggressive surgery combined with radiotherapy may contribute to more effective local control.

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“…19 Margin status, however, has been the subject of conflicting reports on its ability to predict local recurrence of myxofibrosarcoma or UPS. 11,12,17,1819,20 In our dataset, local recurrence developed in 42% of patients who had an R1 resection, compared to 20% of patients with an R0 resection; however, this difference was not statistically significant ( p =0.064), perhaps because our study included only 38 R1 patients.…”

Section: Discussionmentioning

confidence: 56%