We study the frog model with death on the biregular tree T d1,d2 . Initially, there is a random number of awake and sleeping particles located on the vertices of the tree. Each awake particle moves as a discrete-time independent simple random walk on T d1,d2 and has a probability of death (1 − p) before each step. When an awake particle visits a vertex which has not been visited previously, the sleeping particles placed there are awakened. We prove that this model undergoes a phase transition: for values of p below a critical probability p c , the system dies out almost surely, and for p > p c , the system survives with positive probability. We establish explicit bounds for p c in the case of random initial configuration. For the model starting with one particle per vertex, the critical probability satisfies p c (T d1,d2 ) = 1/2 + Θ(1/d 1 + 1/d 2 ) as d 1 , d 2 → ∞.