Recurrence of Major Depressive Disorder in Hospitalized Children and Adolescents

Emslie, Graham J.; Rush, A. John; Weinberg, Warren A.; Gullion, Christina M.; Rintelmann, Jeanne; Hughes, Carroll W.

doi:10.1097/00004583-199706000-00015

Cited by 108 publications

(68 citation statements)

References 44 publications

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“…Other studies have pointed to the persistence of child and adolescent depressive symptoms (Garber et al, 1988;Nolen-Hoeksema et al, 1992) and their predictive power for adult depression (Aalto-Setälä et al, 2002). The high rate of recurrence of depression in children and adolescents has been repeatedly observed (Emslie and Rush, 1997;Lewinsohn and Clerke et al, 1994) and the increased suicidality in young adulthood has been outlined (Weissman and Wolk, 1999).…”

mentioning

confidence: 99%

Psychosocial Factors in Adolescent and Young Adult Self-Reported Depressive Symptoms: Causal or Correlational Associations?

Steinhausen

Haslimeier

Metzke

2006

J Youth Adolescence

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Using a large longitudinal representative community sample, this study identified three groups of subjects who were depressed either in pre-adolescence, late adolescence or early adulthood, and matched by age and gender to controls without depression. The 90th percentile on one or two self-reported symptom scales [i. e. the Center for Epidemilogical Studies Depression Scale (CES-D) or the subscale Anxious / Depressed subscale on either the Youth Self Report (YSR) or the Young Adult Self Report (YASR)] served as the cut-off for the depression groups. Psychosocial variables under study included life events and life events impact, coping, self-related cognitions, perceived parental rearing style, family relations, perceived school environment, and the internalizing (except anxious/depressed) and externalizing problem scale of the YSR/YASR. The study found a large number of time-related correlations between psychosocial factors and depression. Evidence for causal effect (either antecedent or consequent) was obtained only for self-esteem, perceived maternal rejection, and internalizing problems.

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mentioning

confidence: 99%

Psychosocial Factors in Adolescent and Young Adult Self-Reported Depressive Symptoms: Causal or Correlational Associations?

Steinhausen

Haslimeier

Metzke

2006

J Youth Adolescence

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“…Na década de 1990, Harrington et al demonstraram os efeitos deletérios em longo prazo da depressão na infância (Harrington et al, 1994;Harrington, 1993) como uma causa importante de morbidade e mortalidade em crianças e adolescentes no Primeiro Mundo (Emslie et al, 1997). Em adultos, Boylan et al (2004) demonstraram que a depressão tem um papel mais relevante sobre a qualidade de vida do que a freqüência de crises epilépticas.…”

Section: Revisão Da Literaturaunclassified

Depressão em crianças e adolescentes com epilepsia

Valente¹,

Thomé‐Souza²,

Kuczynski³

et al. 2004

Rev. psiquiatr. clín.

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A epilepsia, uma condição neurológica, apresenta uma freqüência elevada de transtornos psiquiátricos, em especial a depressão, que é a comorbidade psiquiátrica mais comum nesta população. Sabe-se que o transtorno depressivo pode comprometer muito mais a qualidade de vida de um paciente com epilepsia do que a gravidade da doença em si, daí a importância do seu diagnóstico. Entretanto, há poucos estudos sobre a prevalência e apresentação clínica da depressão nas crianças e adolescentes com epilepsia e nenhum sobre o seu tratamento. Este artigo tem como objetivo estudar as razões para o subdiagnóstico deste transtorno psiquiátrico e revisar as evidências para a ocorrência de possíveis mecanismos fisiopatológicos comuns. Para tal, revisamos estudos em modelos animais de epilepsia que demonstram uma diminuição de neurotransmissores implicados nos mecanismos patogênicos e tratamento da depressão Adicionalmente, estudamos as evidências oferecidas pelos estudos de neuroimagem e neuropsicológicos que corroboram a existência de uma disfunção das estruturas límbicas -frontais e temporais -nos pacientes com transtorno depressivo, que aparentemente também existe em pacientes com epilepsia. Portanto, este artigo de revisão dá evidência de que o conceito de relação causa-efeito para a ocorrência de depressão em pacientes com epilepsia precisa ser revisto.Palavras-chave: Epilepsia, depressão, crianças, subdiagnóstico. AbstractEpilepsy, a neurological disorder, presents a high frequency of psychiatric disorders, especially depression, which is the most common psychiatric comorbidity in these patients. It's known that depressive disorder may compromise these patient's life more than the severity of epilepsy, pointing to the importance of its diagnosis. However, there are few studies on the prevalence and clinical presentation of depression in childhood and adolescence and none on its treatment. This article aims to study the reasons for the subdiagnosis of this psychiatric disorder and review the evidences for the

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“…Approximately 60% of youth sustain a relapse after initial success in acute treatment (20)(21)(22). At least a part of this somewhat high relapse rate may be due to the natural course of the illness, early discontinuation of treatment, inadequate initial treatment or treatment adherence problems.…”

Section: Sequelae Of Mddmentioning

confidence: 99%

“…The rate of recurrence in depressed youth is approximately 50% within two years and approximately 70% five years after diagnosis (10,(20)(21)(22)(23)(24). Known factors associated with higher recurrence rates include earlier age of initial depressive episode, severity of the first episode, presence of psychotic features, the number of previous episodes, presence of comorbid problems, biological relatives with MDD and a past history of treatment adherence problems.…”

Section: Sequelae Of Mddmentioning

confidence: 99%