Early onset major depressive disorder

Fleisher, William; Katz, Laurence Y.

doi:10.1093/pch/6.7.444

Cited by 15 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the clinical manifestation of BPD, like all personality disorders, occurs early. Although MDD can occur at any age, the average age of developing MDD is 25 ( Fleisher and Katz, 2001 ), hence the young age of our BPD group.…”

Section: Discussionmentioning

confidence: 99%

Disorder-specific characteristics of borderline personality disorder with co-occurring depression and its comparison with major depression: An fMRI study with emotional interference task

Chechko

Kellermann

Augustin

et al. 2016

NeuroImage: Clinical

View full text Add to dashboard Cite

Borderline personality disorder (BPD) and major depressive disorder (MDD) are both associated with abnormalities in the regulation of emotion, with BPD being highly comorbid with MDD. Disorder-specific dysfunctions in BPD, however, have hardly been addressed, hence the lack of knowledge pertaining to the specificity of emotion processing deficits and their commonality with MDD.24 healthy comparison subjects, 21 patients with MDD, and 13 patients with comorbid BPD and MDD (BPD + MDD group) were studied using functional MRI. The subjects were required to perform an emotional interference task that entailed categorizing facial affect while ignoring words that labeled the emotional contents of the external stimuli.Collapsing across emotional face types, we observed that participants with BPD + MDD uniquely displayed a greater involvement of the visual areas and the cerebellum. During emotional conflict processing, on the other hand, the lateral prefrontal cortex (LPFC) appeared to be affected in both patient groups. In comparison to the HC, the MDD group showed differences also in the posterior medial frontal cortex (pMFC) and the inferior parietal lobule (IPL).Thus, our data indicate dysfunctionality in the neural circuitry responsible for emotional conflict control in both disorders. The enhanced visual cortex activation in BPD + MDD suggests the visual system's hyperresponsiveness to faces at an early perceptual level. Not being associated with co-occurring depression, this effect in BPD + MDD appears to represent specific personality traits such as disturbed reactivity toward emotionally expressive facial stimuli.

show abstract

Section: Discussionmentioning

confidence: 99%

Disorder-specific characteristics of borderline personality disorder with co-occurring depression and its comparison with major depression: An fMRI study with emotional interference task

Chechko

Kellermann

Augustin

et al. 2016

NeuroImage: Clinical

View full text Add to dashboard Cite

show abstract

“…It is well known that CP and DS that emerge earlier in adolescence are more severe and more strongly associated with other developmental difficulties, such as substance use, than later-emerging symptoms (Fleisher & Katz, 2001; Moffitt, 1993; Weissman et al, 1999). While no known study has tested age as a moderator of the relation of CP and DS to substance use, several previous studies have noted age differences in the associations of mental health symptoms with substance use.…”

Section: Moderation By Age and Sexmentioning

confidence: 99%

Interaction matters: Quantifying Conduct Problem × Depressive Symptoms interaction and its association with adolescent alcohol, cigarette, and marijuana use in a national sample

Maslowsky

Schulenberg

2013

Dev Psychopathol

View full text Add to dashboard Cite

Substance use is a major contributor to morbidity and mortality among American adolescents. Conduct problems and depressive symptoms have each been associated with adolescent substance use. Although they are highly comorbid, the relation of the interaction of conduct problems and depressive symptoms to substance use in not clear. In a national sample of 8th, 10th, and 12th grade students from Monitoring the Future surveys, latent moderated structural equation modeling was used to estimate the association of conduct problems, depressive symptoms, and their interaction to alcohol, cigarette, and marijuana use. Moderation by age and sex was tested. The interaction of conduct problems with depressive symptoms was a strong predictor of substance use, particularly among younger adolescents. With few exceptions, adolescents with high levels of both conduct problems and depressive symptoms used substances most frequently. Conduct problems were a strong predictor of substance use, with larger effects in males; depressive symptoms were a weak predictor, with larger effects in females. Whereas conduct problems are often thought to be a primary predictor of substance use, this study revealed that depressive symptoms potentiate the relation of conduct problems to substance use. Therefore, substance use prevention efforts should target both depressive symptoms and conduct problems.

show abstract

“…Depression is a common and potentially debilitating disorder occurring through the life-course (Fleisher and Katz, 2001; Patel et al, 2007; Saluja et al, 2004). The first onset of depression often occurs in childhood or adolescence, although treatment typically does not occur until later in life (Birmaher et al, 1996; Costello et al, 2006; Kessler et al, 2007; Patel et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Childhood social adversity and risk of depressive symptoms in adolescence in a US national sample

Björkenstam

Pebley

Burström

et al. 2017

Journal of Affective Disorders

View full text Add to dashboard Cite

Objective Childhood social adversity has been associated with an increased risk of depression and other psychiatric disorders in adolescence and early adulthood. However, the role of timing and accumulation of adversities has not yet been established in longitudinal studies. We examined the association between childhood adversities and adolescent depressive symptoms, and the impact of timing and accumulation of adversity. Method Longitudinal data were obtained from the Child Development Supplement to the Panel Study of Income Dynamics (n=2223), a nationally representative survey of US families that incorporates data from parents and their children. Negative binomial regression analysis was used to estimate effects of childhood social adversity on adolescent depressive symptoms, presented as Incidence Rate Ratios with 95% confidence intervals. Results Children exposed to social adversity reported higher levels of adolescent depressive symptoms captured by two depression scales. Single-parent household and residential instability were particularly associated with depressive symptoms. A positive relationship was found between cumulative adversity and the risk of adolescent depression. The timing of exposure appeared to have little effect on the risk of adolescent depressive symptoms. Limitations The structure of the data implies that alternative causal pathways cannot be fully discounted. The self- or parent-reported data is subject to recall bias. Conclusion Our findings support the long-term negative impact of childhood adversity on adolescent depressive symptoms, regardless of when in childhood the adversity occurs. Policies and interventions to reduce adolescent depressive symptoms need to consider the social background of the family as an important risk or protective factor.

show abstract

Early onset major depressive disorder

Cited by 15 publications

References 43 publications

Disorder-specific characteristics of borderline personality disorder with co-occurring depression and its comparison with major depression: An fMRI study with emotional interference task

Disorder-specific characteristics of borderline personality disorder with co-occurring depression and its comparison with major depression: An fMRI study with emotional interference task

Interaction matters: Quantifying Conduct Problem × Depressive Symptoms interaction and its association with adolescent alcohol, cigarette, and marijuana use in a national sample

Childhood social adversity and risk of depressive symptoms in adolescence in a US national sample

Contact Info

Product

Resources

About