Recurrence and Survival Analyses of 1,115 Cervical Cancer Patients Treated with Radical Hysterectomy

Abstract

Many clinicopathological factors of cervical cancer are still controversial in their prognostic significance. The case records of 1,115 patients who received radical hysterectomy at the Veterans General Hospital, Taipei, from 1980 to 1989 were collected to evaluate prognosis-related factors by univariate and multivariate analyses. The pathology was reviewed retrospectively by one pathologist. Ten parameters known to be prognostic in the literature were included for analysis. Univariate analysis showed that patients with all these factors had higher recurrence rates. However, when the effects of parametrial invasion, progressive stage and stromal invasion were weighed against the presence of lymph node metastasis, their influence on recurrence became unimportant. Nevertheless, these factors still influenced prognosis when there was no lymph node metastasis. Multivariate analysis of both recurrence and survival time in the patients with squamous cell carcinoma shared a consensus that pelvic lymph node metastasis and deep stromal invasion were significant risk factors. We conclude that these simplified and consistent results obtained by multivariate analysis provide a basis for subclassification of patients to predict prognosis and change therapy.

Overall 5-year survival rate and prognostic factors in patients with stage IB and IIA cervical cancer treated by radical hysterectomy and pelvic lymph node dissection

“…Interest in adenocarcinoma of the uterine cervix has increased as a result of its increasing incidence and its possible impact on the overall cervical cancer mortality rate. It remains unclear whether this increase is due to a relative decrease in cervical squamous cell carcinoma or to an absolute increase in the incidence of adenocarcinoma (40–46) . In our study, there was no increased incidence of adenocarcinoma.…”

Detection of disseminated tumor cells in patients with cervical cancer

“…Of these, lymph node involvement is considered to be one of the most important parameters (Yuan et al 1999). Nevertheless, up to 20% of patients with cervical cancer and surgically staged negative pelvic lymph nodes experience recurrent disease (Smiley et al 1991;Larson et al 1988).…”

Prognostic Value of p53 Expression in Stage IB1 Cervical Carcinoma

“…In Taiwan, invasive cervical carcinoma of stage IB and IIA is usually treated with radical hysterectomy and pelvic lymphadenectomy [2]. This type of operation has resulted in reports of a recurrence rate of 10-40% with a 5-year survival rate ranging from 72.1 to 90.3% [3].…”