Rectal Lymphoma in Homosexual Men

Burkes, Ronald L.

doi:10.1001/archinte.1986.00360170127019

Cited by 52 publications

(4 citation statements)

References 17 publications

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“…The differential diagnosis of rectal masses in patients with HIV is broad and includes infectious causes, such as lymphogranuloma venereum, syphilis, CMV, and HHV-8 [1,2,3]. Non-infectious pathologies, such as lymphoma or squamous cell carcinoma, are also important entities to consider in this population [4,5]. We present a patient with herpes simplex virus (HSV) infection who was found to have a rectal mass, with an endoscopic appearance concerning for malignancy.…”

Section: Discussionmentioning

confidence: 99%

Herpes Simplex Virus Proctitis Masquerading as Rectal Cancer

2019

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Herpes simplex virus (HSV) is the leading cause of proctitis in HIV-infected individuals. However, no cases of rectal masses secondary to HSV infection have been reported to date. Herein, we present the case of a 45-year-old man with HIV infection who developed rectal pain and bleeding, along with dysuria and voiding difficulty. Colonoscopy revealed proctitis and a rectal mass with features concerning for rectal cancer. Histologic sections of the rectal mass biopsy demonstrated colorectal mucosa with viral cytopathic changes, ulceration, granulation tissue, marked inflammatory infiltrate, and fibrinopurulent exudate. Immunohistochemistry for herpes simplex virus-1 was positive in epithelial cells demonstrating a viral cytopathic effect. The patient was treated with valacyclovir for 3 weeks, which led to complete resolution of his symptoms. Follow-up sigmoidoscopy at 6 months did not show any masses. Our case illustrates the importance of considering HSV in the differential diagnosis of rectal masses. We advocate the routine use of viral immunohistochemistry for the evaluation of rectal tumors, especially in patients with clinical manifestations and endoscopic findings consistent with proctitis.

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Section: Discussionmentioning

confidence: 99%

Herpes Simplex Virus Proctitis Masquerading as Rectal Cancer

2019

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“…(8) One factor that may be related to the site of involvement is previous sites of injury. Primary muscular lymphoma occurring after leg injury, (10,11) near needle injected sites (12) and in homosexual men's rectums (13) have been reported. Since the lower extremities are vulnerable to injury, this may suggest a relationship between muscular lymphoma and mechanical stimulation.…”

Section: A 2bmentioning

confidence: 99%

A rare case of primary muscular non-Hodgkin’s lymphoma and a review of how imaging can assist in its diagnosis

Hongsakul¹,

Laohawiriyakamol²,

Kayasut³

2013

smedj

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Primary malignant non-Hodgkin's lymphoma of the muscle is rare. Currently, imaging tools are necessary to enable its diagnosis. Herein, we report the case of a patient who presented with swelling and pain in the right thigh and pelvis. Computed tomography findings revealed isodense masses in the patient's right thigh and left iliacus muscle, leading to the initial diagnosis of either primary muscular lymphoma or soft tissue sarcoma. Further investigation with magnetic resonance imaging was done, and a biopsy was performed. The ensuing histological diagnosis was that of diffuse large B-cell lymphoma.

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“…Histologic subsets do have some discriminating patterns of involvement. For example, large-cell tumors preferentially involve the gastrointestinal tract and small-cell tumors the bone marrow and meninges (45,55). The presenting symptoms of lymphoma do not appear to be appreciably affected by HAART (56,57).…”

Section: Clinical Presentation Evaluation and Treatmentmentioning

confidence: 99%

AIDS-Related Malignancies

Scadden

2003

Annu. Rev. Med.

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Immunodeficiency alters the risk of cancer. Specific types of immune dysfunction are associated with different tumor risks, but most tumors are related to oncogenic viruses. In acquired immunodeficiency due to the human immunodeficiency virus (HIV), HIV itself rarely directly causes cancer; rather, it provides the immunologic background against which other viruses can escape immune control and induce tumors. The most common malignancies are Kaposi's sarcoma and non-Hodgkin's lymphoma. This chapter discusses the pathophysiologic background of these tumors, how they have been affected by the use of anti-HIV medications, and their clinical management.

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Rectal Lymphoma in Homosexual Men

Cited by 52 publications

References 17 publications

Herpes Simplex Virus Proctitis Masquerading as Rectal Cancer

Herpes Simplex Virus Proctitis Masquerading as Rectal Cancer

A rare case of primary muscular non-Hodgkin’s lymphoma and a review of how imaging can assist in its diagnosis

AIDS-Related Malignancies

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