Rectal carcinoma metastasizing to the breast: A case report and review of literature

Abstract

Extramammary breast metastases (from non-breast primaries) are rare, constituting only about 2% of all breast metastases, although autopsy studies show that it may occur in up to 6% of cases. Lymphoma, metastatic melanoma, and bronchial carcinoma are the malignancies that account for the majority of breast metastases. Breast metastases from a colorectal carcinoma have been described in only a small number of cases in the literature. We present a case of a 42-year-old woman with an incidental finding of a breast lump. She had a history of Dukes C rectal carcinoma for which she had undergone an anterior resection 11 months earlier. The breast deposit was the first clinical indication of relapse. The patient subsequently developed liver and brain metastases and deteriorated rapidly; she died 2 months after presenting with the breast mass.

Primary Sigmoid Adenocarcinoma Metastasis to the Breast in a 28-Year-Old Female: A Case Study and a Review of Literature

“…Distant metastasis is usually associated with either recurrent or advanced disease,6 and the most common sites for metastasis are local lymph nodes, the liver, and lungs 7…”

Bilateral breast metastasis from mucinous adenocarcinoma of the rectum: a case report and review of the literature

“…Immunohistochemistry in a vast majority of cases identifies the phenotype of carcinoma, CRC is positive for cytokeratin 20, CDX2 and negative for breast markers cytokeratin-7, mammaglobin and ER and PR in greater than 90% of cases (5). Immunohistochemistry done for breast markers i.e, ER, PR, Her 2 was negative in the primary adenocarcinoma of rectum.…”

“…Bilateral breast métastases are very rare and have been seen in a few cases of ovarian carcinoma (2). Breast secondaries from a colorectal neoplasm are rare till date and only 19 such cases have been reported, two of them being in men (4)(5)(6)(7)(8)(9)(10)(11)(12). However, bilateral breast metastasis from adenocarcinoma of the rectum is very rare, ours being the fourth case in the world literature (6).…”

“…Breast métastases are usually seen in the reproductive age group (30-45 years) (5). Bilateral breast metastasis from ovarian cancer show a mean age of 46 years with a mean interval of 22 months and a mean survival of 12 months (2).…”

Rectal Carcinoma Metastatic to the Male Breast after 7 Years: Case Report

“…Colorectal cancer commonly metastasizes to the liver, lungs, brain, and skeletal system, althoughmetastasishasbeendocumentedtouncommonsites (pancreas [2],endobiliarytract [3],adrenalglands [4],externalauditorycanal [5],leftorbit [6],skin [4],andbreast [7]). Metastatic breast tumors arising from extramammary locationsarerareandaccountforlessthan2%ofallbreastmalig-nancies [8].Breastcarcinomafromthecontralateralbreastis themostcommonprimaryneoplasmmetastatictothebreast [9],andtheincidenceofallothersecondarybreastmalignanciesisveryrare.Therearefewerthan20reportsofrectalcar-cinoma metastatic to the breast, and only 2 of these were in men [4,7,10,11].…”