Primary Sigmoid Adenocarcinoma Metastasis to the Breast in a 28-Year-Old Female: A Case Study and a Review of Literature

Abstract

Metastasis to the breast from colorectal carcinoma is rare, only a few cases have been reported in the literature, and no cases have been reported in a young, 28-year-old patient. This report confirms the occurrence of the disease in a younger age group. The patient was referred to the Breast Clinic with a history of a gradually increasing lump in her right breast for two weeks' duration. On clinical examination, a 2-cm firm lump was noted in the upper inner quadrant of the right breast, which was clinically benign; however, histological examination of the breast core biopsy together with immunohistochemistry confirmed metastatic colorectal adenocarcinoma. The primary colorectal carcinoma was later confirmed to be a stage pT4N2M1 tumor, and the Duke stage was C1. Histology with immunohistochemistry is very important in the diagnosis of cases of this nature, but the clinical correlation should be taken into consideration at multidisciplinary team meetings to decide the final management of the patient.

Isolated breast metastasis mimicking as second primary cancer - a case report

“…Most importantly, the great majority of primary breast tumors are CK7-positive and CK20-negative, while colorectal carcinomas are usually CK7-negative and CK20-positive. [16,17] IHC markers used in our case were consistent with these findings as shown in Table 1. The strong nuclear positivity with CDX-2 is highly sensitive and specific for colonic cancers.…”

“…Metastatic carcinomas in the breast are associated with a poor prognosis with a survival rate of less than 12 months from the time of breast tumor diagnosis. [16,19,20] Metastatic disease in the breast is a marker for disseminated metastatic spread, and therefore indicates a poor prognosis. Metastases to the breast are rare in themselves, and such metastasis occurring secondary to a previous anorectal carcinoma makes this case very unusual.…”

Metastasis of rectal signet ring adenocarcinoma to the breast in a young woman after 10 years, a rare case report and review of the literature

“…All of the previous patients except for two have been female patients [4,5]. The age range has been between 28 and 86 years-old, and only one patient with metastatic colon adenocarcinoma in the previous literature has been less than 30 years of age (28 year-old) [6]. Our case has been unique according to the age; it means that our case has been the youngest patient with metastatic colorectal adenocarcinoma to the breast, reported in the whole literature (26-year-old).…”

Metastatic Colonic Adenocarcinoma in Breast: Report of Two Cases and Review of the Literature

“…It is rare to find metastasis of colonic adenocarcinoma to the breast [ 5 , 6 ]. The incidence of metastasis in breast from extramammary sites was 6.6% to 7% in autopsy studies [ 8 ].…”

“…In the published literature, there are very few reported cases of colorectal cancer that metastasized to the breast, and these are mainly seen in the settings of concomitant liver and lung metastasis [ 9 ]. The median age at which breast metastasis present is 54 years, and it is much more commonly found in women than in men (5–8%) [ 5 , 6 , 8 ]. The average time interval to develop metastatic lesions in the breast from a primary source is about two years [ 5 ].…”