Rectal cancer: prognostic indicators of long-term outcome in patients considered for surgery

Abstract

This is one of the largest series of rectal cancers from a single NHS trust. We have demonstrated that age, Dukes' stage and CRM status are associated with long-term survival. These clinical factors are readily available to the surgeon at the time of first post-operative review and can provide a good clinical guide to prognosis.

Outcomes of ultra-low anterior resection combined with or without intersphincteric resection in lower rectal cancer patients

“…The CRM+ has become the most important parameter assessing the quality of rectal cancer surgery, as it unanimously correlated with poor prognostic indicator [15]. Our CRM+ rate (≤1 mm) in both groups using mostly transabdominal approach (2.1 %) appears lower than the previously reported 3.6-38.9 % regardless of operation types [16][17][18]. During the study period, abdominoperineal resection (APR) was performed in 10 % of all rectal cancer patients, in contrast to 20.5 % of lower rectal cancer patients which might include considerable competent cases for ISR.…”

Prognostic Value of Mandard and Dworak Tumor Regression Grading in Rectal Cancer: Study of a Single Tertiary Center

“…After curative surgery with TME, tumor extension through the rectal wall (pT), spreading to the regional lymph nodes (pN) and the circumferential resection margin (CRM) constitute the main criteria to estimate prognosis in rectal carcinoma patients [7]. In LARC, chemoradiotherapy applied before surgery may change the pathologic stage and CRM of the resected specimen.…”

Lymphknotendissektion nach primärer Chirurgie und neoadjuvanter Radiochemotherapie des Rektumkarzinoms

“…Die Prognose nach radikaler chirurgischer Therapie des Rektumkarzinoms wird u. a. von der Anzahl metastatisch befallener Lymphknoten maß-geblich beeinflusst [6]. Dabei hat eine vorhandene Lymphknotenmetastasierung insbesondere Auswirkungen auf das Risiko einer Fernmetastasierung, aber weniger auf die Lokalrezidivraten, sofern eine optimale Chirurgie mit freiem zirkumferenziellen Resektionsrand und kompletter totaler mesorektaler Exzision erreicht wurde [18].…”