Recrystallization of cyclotetramethylenetetranitramine (HMX) using gas anti-solvent (GAS) process

Kim, Soojung; Lee, Byoung‐Min; Lee, Byung‐Chul; Kim, Hyoun-Soo; Kim, Hwayong; Lee, Youn-Woo

doi:10.1016/j.supflu.2011.07.016

Cited by 39 publications

(19 citation statements)

References 20 publications

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“…An importantc ontribution to micronization of HMX by the GAS process was made by Kim et al [215] The experimentsw ere performed using different solvents and variouso perating parameters (temperature, CO 2 addition rate, initial solute concentration,a nd agitation rate). It was observed that the crystal structure and crystal phase of precipitated ultrafine HMX particles mainly dependedo nt he solventu sed in the GAS process.…”

Section: Micronization Of Energetic Compounds In Sub-or Supercriticalmentioning

confidence: 99%

Prospective Symbiosis of Green Chemistry and Energetic Materials

et al. 2017

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A global increase in environmental pollution demands the development of new "cleaner" chemical processes. Among urgent improvements, the replacement of traditional hydrocarbon-derived toxic organic solvents with neoteric solvents less harmful for the environment is one of the most vital issues. As a result of the favorable combination of their unique properties, ionic liquids (ILs), dense gases, and supercritical fluids (SCFs) have gained considerable attention as suitable green chemistry media for the preparation and modification of important chemical compounds and materials. In particular, they have a significant potential in a specific and very important area of research associated with the manufacture and processing of high-energy materials (HEMs). These large-scale manufacturing processes, in which hazardous chemicals and extreme conditions are used, produce a huge amount of hard-to-dispose-of waste. Furthermore, they are risky to staff, and any improvements that would reduce the fire and explosion risks of the corresponding processes are highly desirable. In this Review, useful applications of almost nonflammable ILs, dense gases, and SCFs (first of all, CO ) for nitration and other reactions used for manufacturing HEMs are considered. Recent advances in the field of energetic (oxygen-balanced and hypergolic) ILs are summarized. Significant attention is paid to the SCF-based micronization techniques, which improve the energetic performance of HEMs through an efficient control of the morphology and particle size distribution of the HEM fine particles, and to useful applications of SCFs in HEM processing that makes them less hazardous.

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Section: Micronization Of Energetic Compounds In Sub-or Supercriticalmentioning

confidence: 99%

Prospective Symbiosis of Green Chemistry and Energetic Materials

et al. 2017

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“…Owing to the effects on the solubility, super-saturation, and nucleation, temperature is an important parameter in the GAS process. Most of the researchers considered the effect of temperature in GAS process, Esfandiari and Ghoreishi [19,25,34], Müller et al [48], Bakhbakhi et al [27,49] and Kim et al [50] to name a few. Therefore, the experiments were conducted at different temperatures within the range of 313-338 K to assess the effect of temperature on the size and distribution of ROSCa particles.…”

Section: Effect Of Temperaturementioning

confidence: 99%

Production of Rosuvastatin Calcium Nanoparticles Using Gas Antisolvent Technique

Najafi

Esfandiari

Honarvar

et al. 2021

Period. Polytech. Chem. Eng.

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The activity of pharmaceutical substances crucially depends on the bioavailability of the substances. The bioavailability of drugs in body and their rate of dissolution in the biological fluids are increased if the particle size is decreased. In the present paper, the Gas Anti-Solvent (GAS) method was used to lower the size of rosuvastatin particles. The effects of temperature (313–338 K), pressure (105–180 bar) and initial solute concentration (20–60 mg/ml) were evaluated by Response Surface Methodology (RSM). The optimum initial solute concentration, temperature and pressure were found to be 20 mg/ml, 313 K and 180 bar, respectively which resulted in the minimum particle size. Furthermore, the particles were characterized by Differential Scanning Calorimetry (DSC), Dynamic Light Scattering (DLS), Fourier Transform Infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and X-Ray Diffraction (XRD). The analyses showed that the rosuvastatin particles (60.3 nm) precipitated by GAS process become significantly smaller than the initial particles (45.8 µm).

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“…Many researchers have studied particle formation and micronization using non-conventional techniques [4][5][6][7][8]10,11,13,[23][24][25][26][28][29][30][31][32][33][34][35]. In this section, some key research reports are highlighted.…”

Section: Recent Applications Of Supercritical Fluidmentioning

confidence: 99%

“…Kim et al [30] conducted a research to produce cyclotetramethylenetetranitramine (HMX) particles using GAS process. Authors concluded that by changing the operating parameters of the process it is possible to produce small sized particles of HMX.…”

Section: Asesmentioning

confidence: 99%

Particle formation and micronization using non-conventional techniques- review

Fahim

Zaidul

Bakar

et al. 2014

Chemical Engineering and Processing: Process Intensification

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Due to growing concerns regarding health, safety and the environment, non-conventional methods for particle formation and micronization that are either solvent-less or use environmentally acceptable solvents such as carbon dioxide have come into favor. Supercritical CO (sc CO ) (T>31.1°C, P>7.3MPa) has been used in food and pharmaceutical industries to minimize the use of organic solvents, produce new food products, produce environmentally superior food products and to process and micronize (0.1-5μm) pharmaceuticals. Control of particle size increases the dissolution rate of drugs into the body. Techniques that use sc CO eliminate inherent drawbacks of conventional methods such as thermal or mechanical degradation of the product, poor control of the particle size and morphology, lack of brittleness of some polymers and low encapsulation efficiency. Several techniques have been reported for the particle formation and micronization using supercritical fluids that have been successfully scaled up for commercial use. Supercritical CO has also been used to develop applications for medicines, essential oils, vitamins, food grade polymers, catalysts and pigments. This review highlights the process mechanism of supercritical fluid based techniques as well as some applications on particle formation and micronization.

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Recrystallization of cyclotetramethylenetetranitramine (HMX) using gas anti-solvent (GAS) process

Cited by 39 publications

References 20 publications

Prospective Symbiosis of Green Chemistry and Energetic Materials

Prospective Symbiosis of Green Chemistry and Energetic Materials

Production of Rosuvastatin Calcium Nanoparticles Using Gas Antisolvent Technique

Particle formation and micronization using non-conventional techniques- review

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