Recruitment to a clinical trial from the databases of specialists in Parkinson's disease

Ashburn, Ann; Rüth, Melvin; Fazakarley, Louise; Ballinger, Claire; Lindsay, McLellan D.; Fitton, Carolyn

doi:10.1016/j.parkreldis.2006.06.004

Cited by 20 publications

(16 citation statements)

References 11 publications

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“…Of the 1107 individuals on the databases who were considered for inclusion in the trial (see fig 1), only 142 (13%) were randomised, 25 all of whom had passed the screen for gross cognitive impairment. 12 There was good adherence: of the 142 recruited, 9 (6 were controls) were lost to follow-up at 8 weeks and a further 6 (3 were controls) were lost to follow-up at 6 months.…”

Section: Resultsmentioning

confidence: 99%

A randomised controlled trial of a home based exercise programme to reduce the risk of falling among people with Parkinson's disease

Ashburn

Fazakarley

Ballinger

et al. 2006

Journal of Neurology, Neurosurgery & Psychiatry

305

332

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Objective: To evaluate the effectiveness of a personalised home programme of exercises and strategies for repeat fallers with Parkinson's disease (PD). Method: Patients with a confirmed diagnosis of idiopathic PD, independently mobile, living at home in the community, experiencing more than one fall in the previous 12 months and with intact gross cognitive function were invited to participate in this randomised controlled trial. Usual care was compared with a personalised 6 week, home based exercise and strategy programme. The primary outcomes were rates of falling at 8 weeks and 6 months. Whether participants had repeat fallen, nearly fallen or experienced injurious falls were also examined. Functional Reach, the Berg Balance Test, PD Self-assessment Scale and the Euro Quol were rated by a blinded assessor. Results: Participants were randomised to the exercise (n = 70) and control (n = 72) groups. There was a consistent trend towards lower fall rates in the exercise group at both 8 weeks and 6 months and lower rates of injurious falls needing medical attention at 6 months. Lower rates of repeat near falling were evident for the exercise group at 8 weeks (p = 0.004) and 6 months (p = 0.007). There was a positive effect of exercises at 6 months on Functional Reach (p = 0.009) and quality of life (p = 0.033). No significant differences were found on other secondary outcomes measures. Conclusion: There was a trend towards a reduction in fall events and injurious falls with a positive effect of exercises on near falls and quality of life.

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Section: Resultsmentioning

confidence: 99%

A randomised controlled trial of a home based exercise programme to reduce the risk of falling among people with Parkinson's disease

Ashburn

Fazakarley

Ballinger

et al. 2006

Journal of Neurology, Neurosurgery & Psychiatry

305

332

View full text Add to dashboard Cite

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“…It has been pointed out that the main obstacle to the implementation of clinical experiments in PD is patient recruitment 12,24 . The present study showed a low recruitment rate of 11% during the period of eight months.…”

Section: Recruitmentmentioning

confidence: 99%

“…Several reasons have been cited for the low rates of recruitment in feasibility studies in PD. Ashburn et al 24 cited the inclusion of subjects with PD who were physically and cognitively capable of participating in an exercise program for balance improvement as an obstacle to recruitment, which had a success rate of 13% in a period of one year of study. In the study by Keus et al 25 , the effectiveness of a physical therapy program based on exercises for posture, balance, and gait was evaluated, and the recruitment rate was 14%, although the period had not been defined.…”

Section: Recruitmentmentioning

confidence: 99%

Recruitment rate, feasibility and safety of power training in individuals with Parkinson's disease: a proof-of-concept study

Lima

Rodrigues-de-Paula

2013

Braz. J. Phys. Ther.

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| Background: It has been suggested that power training should be implemented in interventions in Parkinson's disease (PD). However, it is necessary to determine the feasibility and safety of training rapid movements in such individuals. Objectives: To determine the rate of recruitment of potential participants, the rate of attendance at training sessions, the levels of adherence to the intervention, and the rate of adverse events. Method: Patients with PD, users of the national public health system underwent power training of the lower limb muscles three times a week for 10 weeks. The number of people who were screened and recruited was recorded, as well as the rate of attendance at the training sessions and adherence to the intervention protocol. Safety was assessed by the presence of adverse events, pain, number of falls, and risk of injury associated with the intervention. Results: Over the course of eight months, 62 individuals were screened and only 13 completed the program. The rates of attendance and adherence were 88% and 97%, respectively. There were no adverse events during training. Two participants reported joint pain and one reported falls during the training period. Conclusions: The recruitment rate was low due to the subjects' difficulties with transportation and lack of interest. The high rates of adherence and attendance and the absence of adverse events suggest that power training is feasible and safe in PD.

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“…advertisements in newspapers) and use of generic databases have a low likelihood of reaching PD patients since the disease has a relatively low prevalence (<5%), in comparison with cardiovascular or psychiatric conditions [10]. On the other hand, the experience of the "Parkinson's Register of the Dementias and Neurodegenerative Diseases Research Network" in South West of England demonstrated that a register of research-interested PD patients has the potential to maximize inclusivity [8].…”

Section: Infrastructurementioning

confidence: 99%

Recruitment strategies and patient selection in clinical trials for Parkinson's disease: Going viral and keeping science and ethics at the highest standards

Picillo

Kou

Barone

et al. 2015

Parkinsonism & Related Disorders

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Recruitment to a clinical trial from the databases of specialists in Parkinson's disease

Cited by 20 publications

References 11 publications

A randomised controlled trial of a home based exercise programme to reduce the risk of falling among people with Parkinson's disease

A randomised controlled trial of a home based exercise programme to reduce the risk of falling among people with Parkinson's disease

Recruitment rate, feasibility and safety of power training in individuals with Parkinson's disease: a proof-of-concept study

Recruitment strategies and patient selection in clinical trials for Parkinson's disease: Going viral and keeping science and ethics at the highest standards

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