Recruitment strategies and patient selection in clinical trials for Parkinson's disease: Going viral and keeping science and ethics at the highest standards

Picillo, Marina; Kou, Nancy; Barone, Paolo; Fasano, Alfonso

doi:10.1016/j.parkreldis.2015.07.018

Cited by 31 publications

(35 citation statements)

References 44 publications

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“…Third, barriers to effective communication and limited experience of the researchers. Fourth, participants’ mistrust of the research team and fear of adverse events [21] may also play a role. Other challenges encountered during recruiting participants include the potential for psychological harm that may result from the collection of information on painful experiences or concern about research results.…”

Section: Recruitmentmentioning

confidence: 99%

Implementation of genomics research in Africa: challenges and recommendations

Adebamowo

Francis

Tambo

et al. 2018

Global Health Action

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Background: There is exponential growth in the interest and implementation of genomics research in Africa. This growth has been facilitated by the Human Hereditary and Health in Africa (H3Africa) initiative, which aims to promote a contemporary research approach to the study of genomics and environmental determinants of common diseases in African populations. Objective: The purpose of this article is to describe important challenges affecting genomics research implementation in Africa. Methods: The observations, challenges and recommendations presented in this article were obtained through discussions by African scientists at teleconferences and face-to-face meetings, seminars at consortium conferences and in-depth individual discussions. Results: Challenges affecting genomics research implementation in Africa, which are related to limited resources include ill-equipped facilities, poor accessibility to research centers, lack of expertise and an enabling environment for research activities in local hospitals. Challenges related to the research study include delayed funding, extensive procedures and interventions requiring multiple visits, delays setting up research teams and insufficient staff training, language barriers and an underappreciation of cultural norms. While many African countries are struggling to initiate genomics projects, others have set up genomics research facilities that meet international standards. Conclusions: The lessons learned in implementing successful genomics projects in Africa are recommended as strategies to overcome these challenges. These recommendations may guide the development and application of new research programs in low-resource settings.

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Section: Recruitmentmentioning

confidence: 99%

Implementation of genomics research in Africa: challenges and recommendations

Adebamowo

Francis

Tambo

et al. 2018

Global Health Action

View full text Add to dashboard Cite

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“…Many digital platforms, such as Facebook, also provide ample opportunities to pilot test and optimize digital ads over time, based on their performance. Finally, effective recruitment should be multi-modal and employ various resources [5,14,15]. This proved critical even in FI, a virtual PD study not constrained by common recruitment barriers such as geographical location or level of health care access.…”

Section: Applications To Pd Research At Largementioning

confidence: 99%

“…Under such targeted inclusion criteria, achieving necessary sample sizes becomes even more difficult, requiring novel recruitment strategies with broad reach. As such, initiatives to improve patient-centered recruitment and retention remain a priority in PD clinical research [14], where online tools are expanding and accelerating these efforts [15].…”

Section: Introductionmentioning

confidence: 99%

Innovative Recruitment Strategies to Increase Diversity of Participation in Parkinson’s Disease Research: The Fox Insight Cohort Experience

Dobkin

Amondikar

Kopil

et al. 2020

JPD

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Background: Clinical research in Parkinson's disease (PD) faces practical and ethical challenges due to two interrelated problems: participant under-recruitment and lack of diversity. Fox Insight (FI) is a web-based longitudinal study collecting patient-reported outcomes and genetic data worldwide to inform therapeutic studies. FI's online platform provides an opportunity to evaluate online strategies for recruiting large, diverse research cohorts. Objective: This project aimed to determine 1) whether FI's digital marketing was associated with increased enrollment overall and from under-represented patient groups, compared to traditional recruitment methods; 2) the clinical and demographic characteristics of samples recruited online, and 3) the cost of this online recruitment. Method: FI recruitment during a 6-week baseline period without digital promotion was compared to recruitment during several periods of digital outreach. Separate online recruiting intervals included general online study promotion and unique Facebook and Google ad campaigns targeting under-represented subgroups: early PD, late/advanced PD, and residents of underrepresented/rural geographic areas.

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“…Due to the specificity of this method, a greater volume of potential participants can be given information about the trial 43,44 …”

Section: Strategy 9: Dissemination To Specific Clinicsmentioning

confidence: 99%

Strategies to enhance recruitment methods in phantom limb pain clinical trials

et al. 2017

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Phantom Limp Pain (PLP) was first described in 1551. To date, its mechanisms and novel interventions remain mostly untested. Only limited conclusions can be drawn from few and small randomized clinical trials (RCTs) on PLP. In this scenario, recruitment strategies are crucial in order to overcome inherent challenges to recruit PLP subjects for clinical trials. Although there are many methods to enhance recruitment and also retention, in this article we discuss these methods based on a common topic: dissemination. We summarize and discuss 10 strategies of recruitment related to the dissemination of information based on the notion that an increase in trial awareness may lead to both increased recruitment and also increased external generalizability. In addition, in our discussion we included insights based on our experience recruiting PLP patients for our large NIH-sponsored clinical trial. Although specific regulatory considerations need to be considered when choosing the methods of recruitment, which may vary across different countries and Institutional Review Boards (IRBs), these strategies may be applicable to most of research settings.

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Recruitment strategies and patient selection in clinical trials for Parkinson's disease: Going viral and keeping science and ethics at the highest standards

Cited by 31 publications

References 44 publications

Implementation of genomics research in Africa: challenges and recommendations

Implementation of genomics research in Africa: challenges and recommendations

Innovative Recruitment Strategies to Increase Diversity of Participation in Parkinson’s Disease Research: The Fox Insight Cohort Experience

Strategies to enhance recruitment methods in phantom limb pain clinical trials

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