Recreational Dance Practice Modulates Lymphocyte Profile and Function in Diabetic Women

Abstract

This study aimed to investigate the impact of a 16-week dance-based aerobic exercise program on lymphocyte function in healthy and type 2 diabetes mellitus (T2DM) women. We enrolled 23 women: 11 with T2DM and 12 non-diabetic controls. Initially, we performed anthropometry and body composition measurements, afterwards, plasma levels of C-reactive protein, lipids, and glucose were determined. We used flow cytometry to measure the CD25 and CD28 expression in circulating lymphocytes, T-regulatory (Treg) cell percentage, lymphocyte proliferation, and cytokines released by cultured lymphocytes. The T2DM group had a lower proportion of CD28+ cells and a higher percentage of Treg lymphocytes and proliferative capacity at the baseline compared with the control group. After 16 weeks of the program, differences in lymphocytes between the T2DM and the control groups disappeared. The dance program promoted IL-10 increase in both groups. We found decreased IL-4, IL-2, and IL-6 secretion in lymphocytes from the control group and increased IL-17 secretion and IL-10/IL-17 ratio in the T2DM group after the program. The program promoted marked changes in lymphocytes in diabetic women, leading to a balance between the different profiles.

Novel predictor of the occurrence of DKA in T1DM patients without infection: A combination of neutrophil/lymphocyte ratio and white blood cells

“…A previous study about the relationship of NLR with aortic stiffness found that the NLR levels were significantly higher in T1DM patients than in healthy individuals, which was consistent with our findings. It was reported that the increased blood glucose caused a drop in lymphocyte levels [ 33 ], and lymphocytes did not proliferate enough in diabetic patients [ 34 ]. In the context of diabetes, inflammatory responses can be intensified by the hyperglycemic state [ 31 ].…”

Biomolecular Effects of Dance and Dance/Movement Therapy: A Review

“…A study by Passos et al (2021) showed that a four-month program of recreational aerobic dance can decrease blood glucose levels in diabetic women. 11 women with type 2 diabetes and twelve healthy women aged 50-75 completed the dance program, which included two 60-min sessions per week.…”

“…In other cases, the different impact of dance programs on serum triglycerides in healthy versus unhealthy people can be less clear. The study by Passos et al, (2021), which is described above, investigates the effect of regular recreational aerobic dance on diabetic women. By the end of the four-month recreational dance program, both the diabetic and healthy control groups showed 15% decreases in serum triglyceride levels.…”

“…By the end of the treatment, the unhealthy group's average total cholesterol had decreased by 16% (p < 0.001), their LDL cholesterol had lowered by 16% (p < 0.01), and their HDL cholesterol had increased by 15% (p < 0.001), which caused all these values to now be analogous to the values seen in the healthy group. A second example can be seen in the study by Passos et al (2021), that investigates the effect of a 4-week recreational aerobic dance on diabetic women. By the end of the program, the diabetic group's total cholesterol levels had decreased by 15% (p < 0.05), whereas no change was seen in the healthy control group.…”

Physical exercise increases global and gene‐specific (interleukin‐17 and interferon‐γ) DNA methylation in lymphocytes from aged women

“…Body composition (percentage of fat and lean body mass) was estimated using bioimpedance, as described by Passos et al (2021).…”