2015
DOI: 10.3109/10826084.2015.1018550
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Recreational Anabolic-Androgenic Steroid Use Associated With Liver Injuries Among Brazilian Young Men

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Cited by 18 publications
(6 citation statements)
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“…Several patterns of injury such as focal nodular hyperplasia, hepatocellular adenoma [ 27 ], hepatocellular carcinoma [ 28 ], peliosis hepatis [ 29 , 30 ], spontaneous hepatic rupture [ 31 ] and, specially, cholestasis hepatitis [ 11 , 24 , 25 , 26 , 32 , 33 , 34 , 35 , 36 ], have been described. However, in a recent study, AAS hepatotoxicity was associated with a distinct phenotype, characterized by considerable total bilirubin (TB) elevations independent of type of damage, in addition to low values of transaminases and alkaline phosphatase, compared to values in liver injury due to convencional drugs and herbs [ 10 , 11 , 24 , 25 , 26 , 37 ].…”
Section: Reported Cases Of Dietary Supplements-induced Liver Injurmentioning
confidence: 99%
See 1 more Smart Citation
“…Several patterns of injury such as focal nodular hyperplasia, hepatocellular adenoma [ 27 ], hepatocellular carcinoma [ 28 ], peliosis hepatis [ 29 , 30 ], spontaneous hepatic rupture [ 31 ] and, specially, cholestasis hepatitis [ 11 , 24 , 25 , 26 , 32 , 33 , 34 , 35 , 36 ], have been described. However, in a recent study, AAS hepatotoxicity was associated with a distinct phenotype, characterized by considerable total bilirubin (TB) elevations independent of type of damage, in addition to low values of transaminases and alkaline phosphatase, compared to values in liver injury due to convencional drugs and herbs [ 10 , 11 , 24 , 25 , 26 , 37 ].…”
Section: Reported Cases Of Dietary Supplements-induced Liver Injurmentioning
confidence: 99%
“…In 2015, another Brazilian study with 182 asymptomatic young recreational AAS using bodybuilders was performed. They, all ≥18 years old and with AAS use for ≥6 months, presented a wide spectrum of liver injuries that included hepatotoxicity, fatty liver, and liver neoplasm [ 27 ].…”
Section: Reported Cases Of Dietary Supplements-induced Liver Injurmentioning
confidence: 99%
“…[ 10 16 ] A recent study enrolled 182 individuals who used AAS for ≥6 months and found a broad spectrum of liver injuries in this cohort, including hepatotoxicity (46/182) and HA (1/182). [ 17 ] Although AAS-induced HAs are relatively rare, the possibility that oral AAS can induce liver cell proliferation must be taken into consideration.…”
Section: Discussionmentioning
confidence: 99%
“…However, these agents as well as corticosteroids do not appear to ameliorate the liver injury or hasten recovery. 50 Other less frequently reported phenotypes of AASassociated liver injury include nonalcoholic steatohepatitis, 62 focal nodular hyperplasia/hepatocellular adenoma, 63 hepatocellular carcinoma, 64 and peliosis hepatis. 65,66 (►Table 3).…”
Section: Bodybuilding Supplement Hepatotoxicitymentioning
confidence: 99%