Recovery Profiles of T-Cell Subsets Following Low-Dose Total Body Irradiation and Improvement With Cinnamon

Zheng, Xiaodan; Guo, Yuqi; Wang, Lei; Zhang, Honghai; Wang, Shaobo; Wang, Li; An, Lei; Zhou, Xian-Bin; Li, Xia; Yao, Chengfang

doi:10.1016/j.ijrobp.2015.08.034

Cited by 22 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the other Th-cells populations 2.5 Gy X-ray TBI (DR 1.3 Gy/min) increased Th2 cells from day 5 and Treg and Th17 cells from day 8 post-irradiation, while Th1 cells and IFN-γ production was reduced (Zheng et al 2015). This appears to be driven by radiation-induced alterations in transcription factor expression.…”

Section: Inflammatory and Immune System Cellular Responsementioning

confidence: 99%

Radiation, inflammation and the immune response in cancer

et al. 2018

View full text Add to dashboard Cite

Radiation is an important component of cancer treatment with more than half of all patients receive radiotherapy during their cancer experience. While the impact of radiation on tumour morphology is routinely examined in the pre-clinical and clinical setting, the impact of radiation on the tumour microenvironment and more specifically the inflammatory/immune response is less well characterised. Inflammation is a key contributor to short- and long-term cancer eradication, with significant tumour and normal tissue consequences. Therefore, the role of radiation in modulating the inflammatory response is highly topical given the current wave of targeted and immuno-therapeutic treatments for cancer. This review provides a general overview of how radiation modulates the inflammatory and immune response-(i) how radiation induces the inflammatory/immune system, (ii) the cellular changes that take place, (iii) how radiation dose delivery affects the immune response, and (iv) a discussion on research directions to improve patient survival, reduce side effects, improve quality of life, and reduce financial costs in the immediate future. Harnessing the benefits of radiation on the immune response will enhance its maximal therapeutic benefit and reduce radiation-induced toxicity.

show abstract

Section: Inflammatory and Immune System Cellular Responsementioning

confidence: 99%

Radiation, inflammation and the immune response in cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It can activate T-cells and natural killer (NK) cells and increase T-cell proliferation, while reducing the infiltration of the immunosuppressive regulatory T-cell (Treg) in tumor tissues (17, 18). Interestingly, low-dose irradiation has been shown to inhibit or retard the development of both primary and metastatic tumors (19, 20). Since developing tumors create microenvironments that not only support neoplastic growth and metastasis but also significantly reduce the potency of both innate and adaptive anti-cancer immunity (21), the potential SIME of the combination of low-dose irradiation with RT is worth investigating.…”

Section: Introductionmentioning

confidence: 99%

Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation

Liu

Zhou

et al. 2019

Front. Immunol.

View full text Add to dashboard Cite

A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irradiation (L-TBI) in a syngeneic mouse model of breast and colon carcinoma. The combination therapy of H-RT and L-TBI potentially enhanced SIME by infiltration of CD8 + T cell and altering the immunosuppressive microenvironment in non-irradiated subcutaneous tumor lesions. The frequency of IFN-γ, as a tumor-specific CD8 + T cells producing, significantly inhibited the secondary tumor growth of breast and colon. Our findings suggest that L-TBI could serve as a potential therapeutic agent for metastatic breast and colon cancer and, together with H-RT, their therapeutic potential is enhanced significantly.

show abstract

“…Rat anti-mouse antibodies cover APC-CD45, PE-Cy7-CD3, PerCP-CD4, and PE-IL-4 (BD Biosciences, CA, USA). Intracellular cytokine staining was performed following the previous description [ 10 ]. Flow cytometric (BD FACSVerse™, BD Biosciences, USA) data were analyzed with FlowJo software.…”

Section: Methodsmentioning

confidence: 99%

Network Pharmacology-Based Study on the Mechanism of Pinellia ternata in Asthma Treatment

Lyu

Chen

Xia

et al. 2020

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Background. Pinellia ternata (PT), a medicinal plant, has had an extensive application in the treatment of asthma in China, whereas its underlying pharmacological mechanisms remain unclear. Methods. Firstly, a network pharmacology method was adopted to collect activated components of PT from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Targets of PT were assessed by exploiting the PharmMapper website; asthma-related targets were collected from the OMIM website, and target-target interaction networks were built. Secondly, critical nodes exhibiting high possibility were identified as the hub nodes in the network, which were employed to conduct Gene Ontology (GO) comment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway enrichment analysis. Finally, the tissue expression profiles of key candidate genes were identified by the Gene Expression Omnibus (GEO) database, and the therapeutic effect of PT was verified by an animal experiment. Results. 57 achievable targets of PT on asthma were confirmed as hub nodes through using the network pharmacology method. As revealed from the KEGG enrichment analysis, the signaling pathways were notably enriched in pathways of the T-cell receptor signaling pathway, JAK-STAT signaling pathway, and cytokine-cytokine receptor interaction. The expression profiles of candidate genes including Mmp2, Nr3c1, il-10, il-4, il-13, il-17a, il-2, tlr4, tlr9, ccl2, csf2, and vefgα were identified. Moreover, according to transcriptome RNA sequencing data from lung tissues of allergic mice compared to normal mice, the mRNA level of Mmp2 and il-4 was upregulated ( P < 0.001 ). In animal experiments, PT could alleviate the allergic response of mice by inhibiting the activation of T-helper type 2 (TH2) cells and the expression of Mmp2 and il-4. Conclusions. Our study provides candidate genes that may be either used for future studies related to diagnosis/prognosis or as targets for asthma management. Besides, animal experiments showed that PT could treat asthma by regulating the expression of Mmp2 and il-4.

show abstract

Recovery Profiles of T-Cell Subsets Following Low-Dose Total Body Irradiation and Improvement With Cinnamon

Cited by 22 publications

References 32 publications

Radiation, inflammation and the immune response in cancer

Radiation, inflammation and the immune response in cancer

Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation

Network Pharmacology-Based Study on the Mechanism of Pinellia ternata in Asthma Treatment

Contact Info

Product

Resources

About