Recovery of β-carotene from pumpkin using switchable natural deep eutectic solvents

Stupar, Alena; Šeregelj, Vanja; Ribeiro, Bernardo Dias; Pezo, Lato; Cvetanović, Aleksandra; Mišan, Aleksandra; Marrucho, Isabel M.

doi:10.1016/j.ultsonch.2021.105638

Cited by 71 publications

(27 citation statements)

References 39 publications

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“…As an example of such an application, Sharma and Dash utilized a combined ANN and genetic algorithm (ANN-GA) approach for how to establish parameters for a DES-based microwave-assisted extraction process (microwave power, extraction time, liquid–solid ratio, and water percentage in DES) that allowed achieving a high extraction efficiency of phytochemical compounds from black jamun pulp [ 196 ]. Stupar et al applied the RSM and ANN model for the development of an optimized procedure for β-carotene ultrasound-assisted extraction from pumpkin using natural DESs [ 197 ]. Ghaedi et al described the development of linear and quadratic regression models for the prediction of CO 2 solubility in DESs and their aqueous solutions [ 198 ].…”

Section: Simulation Methods For Dessmentioning

confidence: 99%

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Computer Simulations of Deep Eutectic Solvents: Challenges, Solutions, and Perspectives

Tolmachev

Lukasheva

Рамазанов

et al. 2022

IJMS

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Deep eutectic solvents (DESs) are one of the most rapidly evolving types of solvents, appearing in a broad range of applications, such as nanotechnology, electrochemistry, biomass transformation, pharmaceuticals, membrane technology, biocomposite development, modern 3D-printing, and many others. The range of their applicability continues to expand, which demands the development of new DESs with improved properties. To do so requires an understanding of the fundamental relationship between the structure and properties of DESs. Computer simulation and machine learning techniques provide a fruitful approach as they can predict and reveal physical mechanisms and readily be linked to experiments. This review is devoted to the computational research of DESs and describes technical features of DES simulations and the corresponding perspectives on various DES applications. The aim is to demonstrate the current frontiers of computational research of DESs and discuss future perspectives.

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Section: Simulation Methods For Dessmentioning

confidence: 99%

“…Recently, an effective procedure has been developed for β-carotene extraction from pumpkins using DESs based on fatty acids [ 197 ]. To this end, the RSM and ANN approaches were used to optimize the extraction process.…”

Section: Main Directions Of Investigationsmentioning

confidence: 99%

Computer Simulations of Deep Eutectic Solvents: Challenges, Solutions, and Perspectives

Tolmachev

Lukasheva

Рамазанов

et al. 2022

IJMS

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“…The process uses non-toxic, biodegradable solvents that do not affect the extracted extractant. As a result, the purification step of the extract can be omitted, and the extract can be directly used in food [16].…”

Section: Extraction and Sustainable Food Productionmentioning

confidence: 99%

Green Extraction of Carotenoids from Fruit and Vegetable Byproducts: A Review

Kultys

Kurek

2022

Molecules

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Carotenoids are characterized by a wide range of health-promoting properties. For example, they support the immune system and wound healing process and protect against UV radiation’s harmful effects. Therefore, they are used in the food industry and cosmetics, animal feed, and pharmaceuticals. The main sources of carotenoids are the edible and non-edible parts of fruit and vegetables. Therefore, the extraction of bioactive substances from the by-products of vegetable and fruit processing can greatly reduce food waste. This article describes the latest methods for the extraction of carotenoids from fruit and vegetable byproducts, such as solvent-free extraction—which avoids the costs and risks associated with the use of petrochemical solvents, reduces the impact on the external environment, and additionally increases the purity of the extract—or green extraction using ultrasound and microwaves, which enables a significant improvement in process efficiency and reduction in extraction time. Another method is supercritical extraction with CO2, an ideal supercritical fluid that is non-toxic, inexpensive, readily available, and easily removable from the product, with a high penetration capacity.

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“…It could reduce the possibility of oxidative damage [39]. The stability of other hydrophobic pigments such as -carotene in NADES was studied by Stupar et al, 2021. The authors reported that fatty acid NADES containing caprylic acidcapric acid (3:1) optimally extracted -carotene from pumpkin (96.74 g/mL).…”

Section: Stability Of Compounds In Nadesmentioning

confidence: 99%

“…-carotene from pumpkin in NADES has good stability if stored at 4 C. Hydrogen bonding interactions between solute and solvent molecules and pH are related to the stability of carotene in solution [42].…”

Section: Stability Of Compounds In Nadesmentioning

confidence: 99%

Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Lusiana

Ramadon

Jantan

et al. 2021

Plants

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Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites-based nutraceuticals are discussed.

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Recovery of β-carotene from pumpkin using switchable natural deep eutectic solvents

Abstract: Graphical abstract

Cited by 71 publications

References 39 publications

Computer Simulations of Deep Eutectic Solvents: Challenges, Solutions, and Perspectives

Computer Simulations of Deep Eutectic Solvents: Challenges, Solutions, and Perspectives

Green Extraction of Carotenoids from Fruit and Vegetable Byproducts: A Review

Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

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