Recovery of time estimation following moderate to severe traumatic brain injury.

Anderson, Jonathan; Schmitter‐Edgecombe, Maureen

doi:10.1037/a0020333

Cited by 24 publications

(36 citation statements)

References 67 publications

(112 reference statements)

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“…In fact, temporal dysfunctions were observed when the temporal intervals exceeded the working memory span (Schmitter-Edgecombe and Rueda, 2008; Anderson and Schmitter-Edgecombe, 2011) or when the tasks employed required high cognitive functions to be performed (Mioni et al, 2013a,b). The consistent higher temporal variability observed is a sign of impaired frontally mediated cognitive functions that affect temporal representation.…”

Section: Discussionmentioning

confidence: 99%

Temporal dysfunction in traumatic brain injury patients: primary or secondary impairment?

Mioni¹,

Grondin²,

Stablum³

2014

Front. Hum. Neurosci.

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Adequate temporal abilities are required for most daily activities. Traumatic brain injury (TBI) patients often present with cognitive dysfunctions, but few studies have investigated temporal impairments associated with TBI. The aim of the present work is to review the existing literature on temporal abilities in TBI patients. Particular attention is given to the involvement of higher cognitive processes in temporal processing in order to determine if any temporal dysfunction observed in TBI patients is due to the disruption of an internal clock or to the dysfunction of general cognitive processes. The results showed that temporal dysfunctions in TBI patients are related to the deficits in cognitive functions involved in temporal processing rather than to a specific impairment of the internal clock. In fact, temporal dysfunctions are observed when the length of temporal intervals exceeds the working memory span or when the temporal tasks require high cognitive functions to be performed. The consistent higher temporal variability observed in TBI patients is a sign of impaired frontally mediated cognitive functions involved in time perception.

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Section: Discussionmentioning

confidence: 99%

Temporal dysfunction in traumatic brain injury patients: primary or secondary impairment?

Mioni¹,

Grondin²,

Stablum³

2014

Front. Hum. Neurosci.

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“…This may be specifically relevant to brain injury as dopamine release is severely attenuated after focal experimental injury [17], and dopamine transporters and receptor levels are altered in patients with TBI [18, 19]. While relatively few studies have examined timing in TBI patients, the collective data are suggestive of increased variability in timing abilities, and very much task dependent [20–22], particularly when considering injury severity and recovery [23]. To better understand changes in timing due to TBI, and its relation to impulsivity, animal models are needed to parse specific contributing variables.…”

Section: Introductionmentioning

confidence: 99%

Frontal brain injury chronically impairs timing behavior in rats

Scott

Haar

2019

Behavioural Brain Research

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Traumatic brain injury (TBI) affects over 2.8 million people annually, and has been shown to increase motor impulsivity in both humans and animals. However, the root cause of this behavioral disinhibition is not fully understood. The goal of the current study was to evaluate whether timing behavior is disrupted after TBI, which could potentially explain increases in impulsive responding. Twenty-one male three-month old Long-Evans rats were trained on a fixed interval-18 s schedule. Following training, rats were placed on the Peak Interval Procedure, with intermittent peak trials. On peak trials, no behaviors were reinforced and response rates were recorded to determine timing ability. After reaching a stable baseline, rats received bilateral frontal TBI (n = 12) using controlled cortical impact or sham procedures (n = 9). After one week recovery, rats were re-assessed on the Peak Procedure for six weeks. An amphetamine challenge was carried out after behavior reached stable post-injury performance. TBI caused a chronic decrease/acceleration in peak time, increase in response variability, and reduction in response rate. The shifted peak time suggests that altered perception of time may contribute to impairments in response inhibition after TBI. Amphetamine significantly increased response variability, with TBI animals demonstrating greater sensitivity, but did not affect peak time in either group. These data suggest that timing may not be the sole factor explaining impulsive action after TBI given that amphetamine reduced motor impulsivity in prior studies. Further investigations will be needed to dissociate the effects of amphetamine on TBI with regard to timing behavior.

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“…Considering the underestimation pattern observed in neglect (Calabria et al ., ; Danckert et al ., ; Oliveri et al ., , ), it has been previously reported that right brain‐damaged patients without neglect also tend to underestimate durations, while left brain‐damaged patients are relatively spared in duration tasks (Harrington et al ., ; Koch, Oliveri, Carlesimo, & Caltagirone, ; Magnani et al ., ). Moreover, underestimation of durations has been observed in Parkinson's disease (Malapani, Deweer, & Gibbon, ), attentional/hyperactivity deficit disorder (Levin et al ., ), schizophrenia (Lee et al ., ), traumatic brain injury (Anderson & Schmitter‐Edgecombe, ) or patients with frontal or cerebellar lesions (Casini & Ivry, ; Gooch, Wiener, Wencil, & Coslett, ). This lack of specificity goes against the claim that neglect causes a specific underestimation pattern in duration estimation due to impaired attention processes.…”

Section: Discussionmentioning

confidence: 99%

Duration and numerical estimation in right brain‐damaged patients with and without neglect: Lack of support for a mental time line

Masson

Pesenti

Dormal

2015

British J of Psychology

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Previous studies have shown that left neglect patients are impaired when they have to orient their attention leftward relative to a standard in numerical comparison tasks. This finding has been accounted for by the idea that numerical magnitudes are represented along a spatial continuum oriented from left to right with small magnitudes on the left and large magnitudes on the right. Similarly, it has been proposed that duration could be represented along a mental time line that shares the properties of the number continuum. By comparing directly duration and numerosity processing, this study investigates whether or not the performance of neglect patients supports the hypothesis of a mental time line. Twenty-two right brain-damaged patients (11 with and 11 without left neglect), as well as 11 age-matched healthy controls, had to judge whether a single dot presented visually lasted shorter or longer than 500 ms and whether a sequence of flashed dots was smaller or larger than 5. Digit spans were also assessed to measure verbal working memory capacities. In duration comparison, no spatial-duration bias was found in neglect patients. Moreover, a significant correlation between verbal working memory and duration performance was observed in right brain-damaged patients, irrespective of the presence or absence of neglect. In numerical comparison, only neglect patients showed an enhanced distance effect for numerical magnitude smaller than the standard. These results do not support the hypothesis of the existence of a mental continuum oriented from left to right for duration. We discuss an alternative account to explain the duration impairment observed in right brain-damaged patients.

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Recovery of time estimation following moderate to severe traumatic brain injury.

Cited by 24 publications

References 67 publications

Temporal dysfunction in traumatic brain injury patients: primary or secondary impairment?

Temporal dysfunction in traumatic brain injury patients: primary or secondary impairment?

Frontal brain injury chronically impairs timing behavior in rats

Duration and numerical estimation in right brain‐damaged patients with and without neglect: Lack of support for a mental time line

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