Recovery of Realistic Polymer Melts after Simple Shear Flows

Borgbjerg, Ulrik; Pablo, Juan

doi:10.1021/ma00117a024

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…Despite the fact that there is no inclusion complex between CD and LA formulation in clinical use, some patents have described LA:CD compositions Table 4 [135][136][137][138].…”

Section: Cyclodextrins-based La Formulationsmentioning

confidence: 99%

“…Borgbjerg, in 1995 [135] described the formation of LA complexes with HP--CD in aqueous solution at 0.01 to 15%. The inventors described an increase on duration of action and in the maximum effect of lidocaine and BVC after complexation with HP--CD.…”

Section: Cyclodextrins-based La Formulationsmentioning

confidence: 99%

“…The development of long lasting LA formulations has been investigated worldwide for decades: the first patent on a drug delivery system for LA was focused in topical application [60] as well as the majority of the existent technologies Table 3 [56,58,[122][123][124][125][126][127][128][129][130][131][132][133][134][135][136][137][138][139][140][141][142], regarding these compounds. The first liposome-based formulation was patented in 1987 Table 1 while cyclodextrins and polymerbased formulations appeared after 1995 Table 4 and 2001 Table 5, respectively.…”

Section: Current and Future Developmentsmentioning

confidence: 99%

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Drug Delivery Systems for Local Anesthetics

Paula¹,

Cereda²,

Tófoli³

et al. 2010

DDF

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Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to systemically deliver LA include the encapsulation in liposomes, complexation in cyclodextrins, association with biopolymers and others carrier systems. Topical delivery systems for LA are characteristically composed by a diversity of adjuvants (viscosity inducing agents, preservatives, permeation enhancers, emollients,) and presentations such as semisolid (gel, creams, ointments), liquid (o/w and w/o emulsions, dispersions) and solid (patches) pharmaceutical forms. The proposed formulations aims to reduce the LA concentration used, increase its permeability and absorption, keep the LA at the target site for longer periods prolonging the anesthetic or analgesic effect and, finally, to decrease the clearance, local and systemic toxicity. This review deals with the innovations pertaining to formulations and techniques for drug-delivery of topical and injectable local anesthetics, as described in recent patents.

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“…Despite the fact that there is no inclusion complex between CD and LA formulation in clinical use, some patents have described LA:CD compositions Table 4 [135][136][137][138].…”

Section: Cyclodextrins-based La Formulationsmentioning

confidence: 99%

Section: Cyclodextrins-based La Formulationsmentioning

confidence: 99%

Section: Current and Future Developmentsmentioning

confidence: 99%

See 1 more Smart Citation

Drug Delivery Systems for Local Anesthetics

Paula¹,

Cereda²,

Tófoli³

et al. 2010

DDF

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“…In spite of the fact that the complexation ability of a wide range of local anesthetics has been studied, there is a rather low number of products derived from these studies which are clinically applied for transdermal drug delivery. In fact, there are several patents, already reviewed [81], which refer to various combinations of cyclodextrin (derivatives)/local anesthetics compositions [82][83][84][85] The complexation of NSAIDs (nonsteroidal antiinflamatory drugs) with -cyclodextrin has also been studied by several groups. [86][87][88][89].…”

mentioning

confidence: 99%

Nanotechnology approaches for pain therapy through transdermal drug delivery

Peptu¹,

Rotaru²,

Ignat³

et al. 2015

CPD

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The paper focuses on the advances in the field of pain treatment by transdermal delivery of specific drugs. Starting from a short description of the skin barrier, the pharmacodynamics and pharmacokinetics including absorption, distribution, action mechanism, metabolism and toxicity, aspects related to the use of pain therapy drugs are further discussed. Most recent results on topical anesthetic agents as well as the methods proved to overcome the skin barrier and to provide efficient delivery of the drug are also discussed. The present review is proposing to summarize the recent literature on the pharmacotherapeutic principles of local anesthetics and non-steroidal anti-inflammatory drugs, generally used to alleviate pain but also the drugs as nanoformulations with potential applications in transdermal delivery. A special attention is given to efficient formulations meant for transdermal penetration enhancement of anesthetics where the drug is encapsulated into macrocyclic molecules (cyclodextrins, cyclodextrin derivatives), liposomes or polymer nanoparticles and hydrogels.

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Transient rheometry

Wissbrun¹

1998

Rheological Measurement

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Recovery of Realistic Polymer Melts after Simple Shear Flows

Cited by 4 publications

References 2 publications

Drug Delivery Systems for Local Anesthetics

Drug Delivery Systems for Local Anesthetics

Nanotechnology approaches for pain therapy through transdermal drug delivery

Transient rheometry

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