Recovery of neurocognitive functions following sustained abstinence after substance dependence and implications for treatment

Schulte, Mieke H J; Cousijn, Janna; Uyl, Tess E. den; Goudriaan, Anna E.; Brink, Wim van den; Veltman, Dick J.; Schilt, Thelma; Wiers, Reinout W.

doi:10.1016/j.cpr.2014.08.002

Cited by 115 publications

(122 citation statements)

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“…METH addiction is a complex neuropsychiatric syndrome that is accompanied by pervasive changes in behaviors 40 and a high rate of recidivism. 41 The recent development of animal models that better mimic drug addiction in rodents 29,30,42 should help to improve the characterization of cellular and molecular substrates …”

Section: Discussionmentioning

confidence: 99%

Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence

et al. 2016

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Epigenetic consequences of exposure to psychostimulants are substantial but the relationship of these changes to compulsive drug taking and abstinence is not clear. Here, we used a paradigm that helped to segregate rats that reduce or stop their methamphetamine (METH) intake (nonaddicted) from those that continue to take the drug compulsively (addicted) in the presence of footshocks. We used that model to investigate potential alterations in global DNA hydroxymethylation in the nucleus accumbens (NAc) because neuroplastic changes in the NAc may participate in the development and maintenance of drug-taking behaviors. We found that METH-addicted rats did indeed show differential DNA hydroxymethylation in comparison with both control and nonaddicted rats. Nonaddicted rats also showed differences from control rats. Differential DNA hydroxymethylation observed in addicted rats occurred mostly at intergenic sites located on long and short interspersed elements. Interestingly, differentially hydroxymethylated regions in genes encoding voltage (Kv1.1, Kv1.2, Kvb1 and Kv2.2)-and calcium (Kcnma1, Kcnn1 and Kcnn2)-gated potassium channels observed in the NAc of nonaddicted rats were accompanied by increased mRNA levels of these potassium channels when compared with mRNA expression in METH-addicted rats. These observations indicate that changes in differentially hydroxymethylated regions and increased expression of specific potassium channels in the NAc may promote abstinence from drug-taking behaviors. Thus, activation of specific subclasses of voltage-and/or calcium-gated potassium channels may provide an important approach to the beneficial treatment for METH addiction.

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Section: Discussionmentioning

confidence: 99%

Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence

et al. 2016

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“…Existe um crescente número de estudos demonstrando que não apenas o uso crônico, mas também variáveis de uso podem influenciar a ocorrência, localização e persistência dos prejuízos cognitivos (Bolla et al, 1999;Vonmoos et al, 2013;Schulte et al, 2014).…”

Section: Variáveis De Uso De Cocaína E O Funcionamento Cognitivounclassified

“…Aspectos como duração, frequência e intensidade do uso de cocaína têm sido relacionados a piores desempenhos das FE (Bolla et al, 1999;Verdejo-García et al, 2007;MadozGúrpide et al, 2011;Del Mar Capella et al, 2015), enquanto que o início precoce do uso de substâncias também sugere um agravamento destes prejuízos (Schulte et al, 2014;Vonmoos et al, 2014). Desta forma, as variáveis de uso de cocaína tornam-se indicadores úteis para a caracterização de gravidade do TUC.…”

Section: Variáveis De Uso De Cocaína E O Funcionamento Cognitivounclassified

“…Apesar de ainda serem escassas as investigações sobre o impacto da idade de início sobre o desempenho cognitivo de pacientes com TUC, esta variável parece representar um dado relevante para a compreensão dos prejuízos relacionados ao quadro (Schulte et al, 2014;Del Mar Capella et al, 2015). Estudos apontam diversas consequências negativas associadas ao uso precoce, que incluem o abandono dos estudos, problemas comportamentais, desenvolvimento de transtornos mentais (relacionados ou não ao uso de substâncias) e suicídio (Grant e Dawson, 1998;Castellanos-Ryan et al, 2013).…”

Section: Idade De Iníciounclassified

“…A duração do uso em anos, por exemplo, melhor explicou o baixo desempenho em planejamento e velocidade de processamento entre usuários de múltiplas substâncias (Del Mar Capella et al, 2015). (Schulte et al, 2014).…”

Section: Duração Do Usounclassified

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Funcionamento cognitivo, variáveis de uso e critérios diagnósticos do transtorno por uso de cocaína: um estudo envolvendo a correlação entre diferentes medidas de gravidade e suas implicações prognósticas

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Diagnosis and Treatment of Mental Disorders Across the Lifespan

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Recovery of neurocognitive functions following sustained abstinence after substance dependence and implications for treatment

Cited by 115 publications

References 99 publications

Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence

Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence

Funcionamento cognitivo, variáveis de uso e critérios diagnósticos do transtorno por uso de cocaína: um estudo envolvendo a correlação entre diferentes medidas de gravidade e suas implicações prognósticas

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