1978
DOI: 10.1038/bjc.1978.27
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Recovery of immune competence after tumour resection in mice: correlation with loss of suppressor elements

Abstract: Changes in the immune competence and levels of suppressore elements were assessed by mitogen stimulation and in vitro antibody production, after resection of a transplantable sarcoma. Spleen cells from tumour-resected animals were found to have depressed responses to conA as well as to the antigens SRBC and DNP-LPS. This inability to respond was gradually overcome and, by Day 21 after resection, spleen cell competence had returned to normal levels. Suppressor cells isolated from the spleens of tumour-resected … Show more

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Cited by 9 publications
(2 citation statements)
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“…Although it is clear that various effector and suppressor immune mechanisms may operate in tumorbearing hosts (reviewed by Kirchner, 1978;Mikulski and Muggia, 1978;and Broder et al, 1978) there are relatively few studies on the dynamic interaction of these factors during tumor growth (Barski and Youn, 1969;Lamon et al, 1972;Bansal and Sjogren, 1973;Youn et al, 1975;Deckers et al, 1973;Gascoyne et al, 1978;Jurin and Plavsic, 1978;Huber and Lucas, 1978). Such investigations are necessary for our further understanding of immunoregulatory mechanisms that permit tumor escape through compromising effector immune reactions of the host.…”
Section: In Plasmacytoma-bearing Micesupporting
confidence: 75%
“…Although it is clear that various effector and suppressor immune mechanisms may operate in tumorbearing hosts (reviewed by Kirchner, 1978;Mikulski and Muggia, 1978;and Broder et al, 1978) there are relatively few studies on the dynamic interaction of these factors during tumor growth (Barski and Youn, 1969;Lamon et al, 1972;Bansal and Sjogren, 1973;Youn et al, 1975;Deckers et al, 1973;Gascoyne et al, 1978;Jurin and Plavsic, 1978;Huber and Lucas, 1978). Such investigations are necessary for our further understanding of immunoregulatory mechanisms that permit tumor escape through compromising effector immune reactions of the host.…”
Section: In Plasmacytoma-bearing Micesupporting
confidence: 75%
“… 6 Removal of the tumor was found to restore lymphocyte function in a murine model. 7 We hypothesized that reduction of the tumor volume may have played a critical role in the success in this patient. The CO 2 laser offers precise excision of oral carcinoma, a better visualization of the operational field, and minimal blood loss.…”
Section: Discussionmentioning
confidence: 97%