Recalcitrant lip verrucous carcinoma successfully treated with acitretin after carbon dioxide laser ablation

Lee, Chaw-Ning; Huang, Chun-Cheng; Lin, I-Chun; Lee, Julia Yu‐Yun; Ou, Chien Hui; Wong, Tak‐Wah

doi:10.1016/j.jdcr.2018.02.002

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…This could further suggest the aggressive nature of our patient's verrucous carcinoma to be attributed to the inflammatory changes and lichenification in the affected area. Of the six reported cases of verrucous carcinoma managed with acitretin (Table 1), five have shown complete remission 25–29 and one case of disease control 30 . Along with our case, this suggests that the use of systemic acitretin with surgical excision is beneficial in management of vulval verrucous carcinoma.…”

Section: Discussionsupporting

confidence: 75%

Oral retinoid, acitretin, is effective in the management of resistant recurrent vulval verrucous carcinoma: A case report

Fox

Elghobashy

Hamad

et al. 2020

J of Obstet and Gynaecol

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Verrucous carcinomas are a rare variant of squamous cell carcinoma. Vulval verrucous carcinoma comprises only 1% of vulval malignancies. This case report discusses the successful management of aggressive recurrent vulval verrucous carcinoma with acitretin, an oral synthetic retinoid used to manage severe psoriasis, after multiple surgical interventions and radiotherapy had failed. This is the first reported case in which verrucous carcinoma had recurred in a musculocutaneous graft. To manage the recurrence, the patient underwent radiotherapy, which did not resolve the condition. The patient was then administered acitretin 25 mg once daily, which successfully resolved the condition, and the patient has been symptom free for 6 months. This report aims to propose the use of acitretin as a management option for recurrent verrucous carcinomas.

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Section: Discussionsupporting

confidence: 75%

Oral retinoid, acitretin, is effective in the management of resistant recurrent vulval verrucous carcinoma: A case report

Fox

Elghobashy

Hamad

et al. 2020

J of Obstet and Gynaecol

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“…The laser ablation affords accurate resection, limited blood loss, as well as minimal contraction and scarring ( 16 ). But laser therapy also needs to be repeatedly operated, and a more extensive case series need to be explored ( 17 , 18 ). Since the procedure of PDT is excruciating for regions with abundant nerve endings, there may be poor patient compliance in the application of lip disorders ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

A huge verrucous carcinoma of the lower lip reconstructed by double Abbe flap: A case report and literature review

et al. 2023

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Lip verrucous carcinoma is a rare low-grade neoplasm, with an unsightly appearance and locally aggressive nature. Treatment of verrucous carcinoma is as yet challenging, no well-defined guidelines for effective and safe management of this disease are available. A case of a patient with a huge verrucous carcinoma of the lower lip successfully treated by surgical excision and double Abbe flap reconstruction technique is presented, and striking features of lip locations of this tumor as well as their management are discussed.

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“… 94 Several authors reported good clinical response with complete tumour removal and no recurrence in a follow-up from 15 to 48 months. 94 , 95 , 96 …”

Section: Treatmentmentioning

confidence: 99%

“…94 Several authors reported good clinical response with complete tumour removal and no recurrence in a follow-up from 15 to 48 months. [94][95][96] Described procedures are non-invasive and can be safely carried out in a local anaesthesia in the outpatient clinic. Other reported advantages are short procedure duration, ability to treat multifocal lesions, limited pain and scarring, fast homeostasis and healing process, low risk of secondary infection and little or no side effects.…”

Section: Non-surgical Techniquesmentioning

confidence: 99%

Oral verrucous carcinoma: a diagnostic and therapeutic challenge

Kristofelc¹,

Zidar

Strojan

2023

Radiology and Oncology

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Background Verrucous carcinoma is a low-grade variant of squamous cell carcinoma with specific morphologic, cytokinetic and clinical features. Despite low mitotic activity and slow growth, it can infiltrate adjacent tissues in advanced stages but does not metastasize. The most frequently affected site is the oral cavity. The following article provides latest updates in the etiology, clinical presentation, diagnostics and treatment options in oral verrucous carcinoma and discusses the existing dilemmas linked to this unique malignancy. Conclusions Oral verrucous carcinoma must be differentiated from conventional squamous cell carcinoma due to its less aggressive behaviour with a more favourable prognosis. Close communication between clinician and pathologist is mandatory for making a correct diagnosis. Primary surgery with negative surgical margins seems to be the most successful treatment. However, management recommendations are not uniform since they are mostly based on case reports and small retrospective case series. Prospective and pooled multi-institutional studies are therefore needed.

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Recalcitrant lip verrucous carcinoma successfully treated with acitretin after carbon dioxide laser ablation

Cited by 6 publications

References 11 publications

Oral retinoid, acitretin, is effective in the management of resistant recurrent vulval verrucous carcinoma: A case report

Oral retinoid, acitretin, is effective in the management of resistant recurrent vulval verrucous carcinoma: A case report

A huge verrucous carcinoma of the lower lip reconstructed by double Abbe flap: A case report and literature review

Oral verrucous carcinoma: a diagnostic and therapeutic challenge

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