Recovery of 0.1Hz microvascular skin blood flow in dysautonomic diabetic (type 2) neuropathy by using Frequency Rhythmic Electrical Modulation System (FREMS)

Bocchi, Leonardo; Evangelisti, A.; Barrella, Massimo; Scatizzi, L.; Bevilacqua, Maurizio

doi:10.1016/j.medengphy.2010.02.004

Cited by 21 publications

(19 citation statements)

References 32 publications

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“…17 Several authors described the effectiveness of FREMS in the treatment of painful diabetic neuropathies. [11][12][13] In these studies, in addition to its analgesic effect, FREMS treatment was shown to improve cutaneous blood flow measured by laser doppler flowmetry and partial tissue tension of oxygen and carbonic anhydride by oxymetry 11,13 and also several other functional peripheral nerve parameters, such as electroneurography and vibration perception threshold. 12 The present study suggested a greater effectiveness of FREMS and topical treatment as compared to topical treatment alone in patients with chronic and painful venous leg ulcers.…”

Section: Discussionmentioning

confidence: 99%

“…10 Among physical therapies that use electrical stimulation, frequency rhythmic electrical modulation system (FREMS) is an innovative type of transcutaneous electrotherapy used in the rehabilitation setting for the treatment of pain, especially in patients with diabetes mellitus. [11][12][13][14] This method uses sequences of modulated electrical stimuli that vary automatically in terms of pulse frequency, duration, and voltage amplitude. The FREMS method was designed on the basis of the hypothesis that the summation of subthreshold electrical stimuli, conveyed through the skin proximal to a motor nerve in a noninvasive system, would induce composite motor action potentials in excitable tissues through specific sequences of weak impulses, characterized by a rapid increase and decrease in pulse frequency and duration, which results in the gradual recruitment of membrane potentials in the stimulated tissues.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of the Frequency Rhythmic Electrical Modulation System for the Treatment of Chronic and Painful Venous Leg Ulcers in Older Adults

Santamato

Panza²,

Fortunato

et al. 2012

Rejuvenation Research

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Frequency rhythmic electrical modulation system (FREMS) is an innovative type of transcutaneous electrotherapy used in a rehabilitation setting for the treatment of pain, especially in diabetic patients. In a randomized clinical trial, we tested the hypothesis that FREMS is effective in the treatment of chronic and painful venous leg ulcers in 20 older patients. Group A (10 patients) received FREMS and topical treatment, whereas group B (10 patients) received topical treatment alone. Over a period of 3 consecutive weeks, 15 treatment sessions were done for each group. Wound healing and tissue repair were evaluated with the Visitrack digital planimetry system and photos. Pain was evaluated using the Visual Analogic Scale (VAS). The measurements were done at baseline and after 5, 10, and 15 days of treatment, with follow-up measurements after 15 and 30 days from the last treatment session. Group A showed a statistically significant decrease in ulcer area during the treatment and follow-up. The VAS score showed a statistically significant decrease after 5 and 10 days of treatment. Group B showed a statistically decrease in ulcer area after 5, 10, and 15 days of treatment with a reduction of VAS score only at 15 days of follow-up. At the end of the treatment, the comparison of the change in ulcer area and the change in VAS score of each group showed a statistically significant difference between groups, suggesting the therapeutic and analgesic efficacy of FREMS in reducing pain and area of chronic venous leg ulcers in older adults. Further investigation is needed to determine its reproducibility in larger case series or randomized clinical trials with longer follow-up periods.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effectiveness of the Frequency Rhythmic Electrical Modulation System for the Treatment of Chronic and Painful Venous Leg Ulcers in Older Adults

Santamato

Panza²,

Fortunato

et al. 2012

Rejuvenation Research

View full text Add to dashboard Cite

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“…In order to comply with privacy and data protection regulations, the data was treated in anonymous form, and only subject age and sex were associated to the recorded signals. The trial involved a group of 40 subjects, partially acquired in previous experiments [11]. Subject age ranged from 20 to 74 years (mean = 39.075, SD =14.947).…”

Section: A Data Acquisitionmentioning

confidence: 99%

“…Participants agreed to participate in the study after receiving complete information on the purpose of the research and the procedures involved and signed the informed consent form, accordingly to ethical requirements as prescribed by Helsinky declaration. All measurements were performed at a controlled room temperature, which was set approximately at 21 o C. Details of the procedure are reported in [11], and summarized here. However, in the current experiment, no treatments were applied to the subject beside thermal stimulation, thus the measurements were completely not-invasive.…”

Section: A Data Acquisitionmentioning

confidence: 99%

Analysis of the microcirculatory pulse wave: age-related alterations

Straface

Landini

Barrella

et al. 2015

2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Morphological analysis of the pulse wave of central blood pressure signal is commonly used for the study of cardiac and vascular properties, but very few attempts were performed for analyzing the peripheral pulse wave of blood flow. In this work, we analyzed this waveform using classical methods, based on the application of FFT, followed by principal components analysis, for assessing the properties of the blood flow. As a sample problem, we evaluated the capability of the proposed method of assessing the alterations correlated with the aging of the vascular system. Results show a good discrimination between the different age groups, confirming the validity of the approach.

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“…This process associated with the expression of cytokines, as well as angiogenic factors such as VEGF. Moreover, that the smooth vascular muscles expand is to deliver oxygen for connective tissue and also increased blood flow velocity 20) . It was well known that FIR energy radiation can heat and activate blood circulation of living bodies 21,22) .…”

Section: Introductionmentioning

confidence: 99%

The Ceramics Radiating Far Infrared Ray Energy (Rhyolite) Promote the Formation of Bone

Dolgorsuren

Yamashita

Dalkhsuren

et al. 2014

J. Hard Tissue Biology.

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Far infrared ray (FIR) energy radiated by the natural ceramics (Rhyolite) cooled FIR ceramics activates water molecules and blood circulation to stimulate skin and other tissues. The aim of our study is to make clear whether the FIR ceramics radiating FIR energy affect or not on the new bone formation in vivo and in vitro. Methods: MC3T3-E1 cells were cultured in FIR CO 2 incubator. The cell proliferation and the gene expression were analyzed by using WST-8 assay kit, RT-PCR and micro array analysis. The enzyme activities were analyzed by using the api R ZYM kit. Furthermore, titanium and natural FIR ceramics compounds were implanted under the periosteium of rat skull bone by injection method. Four weeks later, the samples were examined by the light microscope and micro CT analyses. Results: Proliferation of MC3T3-E1 cell was and DNA concentrations were inhibited by FIR energy radiation. The ALP activities were accelerated and the area of calcification nodules increased on 4 weeks. The RT-PCR data showed that the gene Runx2, Osterix, BSP, OCN, Col1a1 and OPN expression of MC3T3-E1 osteoblast like cells was activated. Bone mineral density (BMD mg/cm²) of implanted sites of T50-F50, T25-F75 and F100 groups was significantly enhanced after 4 weeks compared with control groups. This data shows FIR energy radiation by the natural FIR ceramics promoted bone-forming activity of osteoblasts. Significance: This study suggested that new bioactive ceramics such us natural FIR ceramics was useful for some clinically applications to repair bone defects for example of dental implant surgery.

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Recovery of 0.1Hz microvascular skin blood flow in dysautonomic diabetic (type 2) neuropathy by using Frequency Rhythmic Electrical Modulation System (FREMS)

Cited by 21 publications

References 32 publications

Effectiveness of the Frequency Rhythmic Electrical Modulation System for the Treatment of Chronic and Painful Venous Leg Ulcers in Older Adults

Effectiveness of the Frequency Rhythmic Electrical Modulation System for the Treatment of Chronic and Painful Venous Leg Ulcers in Older Adults

Analysis of the microcirculatory pulse wave: age-related alterations

The Ceramics Radiating Far Infrared Ray Energy (Rhyolite) Promote the Formation of Bone

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