Reconstructive Surgery for Invasive Squamous Carcinoma of the Glans Penis

Smith, Yuko; Hadway, Paul; Biedrzycki, Olaf J.; Perry, Matthew; Corbishley, Catherine M.; Watkin, N.

doi:10.1016/j.eururo.2007.02.038

Cited by 133 publications

(73 citation statements)

References 19 publications

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“…Although the local control rate of PE is ~95% (1), it has a significant negative impact on the patient's sexual function, quality of life, social interactions, self-image and self-esteem (2). During the past decade, there has been a change in the management of primary tumors with an emphasis on penile sparing surgery (PSS) (3). This change has been driven by an improved understanding of the biology of the disease (4), quality improvements in pathological evaluation and continuous refinements of surgical techniques (5).…”

Section: Introductionmentioning

confidence: 99%

“…This change has been driven by an improved understanding of the biology of the disease (4), quality improvements in pathological evaluation and continuous refinements of surgical techniques (5). PSS has been previously reported to produce excellent cosmetic and functional results without sacrificing oncological outcomes in certain patients with early-stage penile tumors (3,(6)(7)(8)(9). Accordingly, an organ-sparing approach has been recommended for patients with stage T1 disease, according to the 2009 TNM clinical and pathological classification system (10), in national and international guidelines (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Surgical treatment of primary disease for penile squamous cell carcinoma: A Surveillance, Epidemiology, and End Results database analysis

Zhu

Wang

et al. 2015

Oncology Letters

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Abstract. Current guidelines recommend penile sparing surgery (PSS) for selected penile cancer cases. The present study described the use of PSS in a population-based cohort, and also examined the role of PSS on penile cancer-specific mortality (PCSM). Data from the Surveillance, Epidemiology, and End Results (SEER) database were used to identify individuals that were diagnosed with penile squamous cell carcinoma between 1998 and 2009 and treated with surgery. Patients were sorted into two groups: Local tumor excision (LTE) and partial/total penectomy (PE). Factors associated with the receipt of LTE and PCSM following LTE were examined. In addition, PCSM was compared between LTE and PE following propensity score matching. Of the 1,292 eligible patients, 24.2% underwent LTE. For stage T1 disease, the rates of LTE increased moderately from 29 to 40% over the last decade. Following multivariate analyses, young age, African descent, a tumor size of <3 cm and stage T1 disease were identified to positively influence the receipt of LTE. With a median follow-up period of 55 months, the four-year PCSM rate was 9.8% in patients treated with LTE. Older age, a tumor size of 3-4 cm and regional/distant disease (SEER stage) were significant predictors of PCSM. Furthermore, in matched cohorts with stage T1 disease, the four-year PCSM rates were 8.9 and 10.0% for patients that received LTE or PE, respectively (P=0.93). In conclusion, underuse of PSS is pronounced in the general community with significant age and ethnicity disparities. The current population-based study provides evidence supporting the oncological safety of PSS compared with PE in early-stage disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surgical treatment of primary disease for penile squamous cell carcinoma: A Surveillance, Epidemiology, and End Results database analysis

Zhu

Wang

et al. 2015

Oncology Letters

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“…Treatment guidance recommends preservation of as much of the penis whenever possible although it is still necessary to remove a margin of normal penile tissue (Pizzocaro et al, 2010, Hegarty et al, 2008. Traditionally, a margin of at least 2cm of normal tissue be removed (Hegarty et al, 2008, Branney et al, 2011 although some studies suggest that more conservative surgery may be safe in the treatment of localised penile cancer (Smith et al, 2007, Minhas et al, 2005. Chemotherapy and radiotherapy are restricted to adjuvant use or palliative treatment of extensive disease (Branney et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The impact of surgical treatment for penile cancer – Patients' perspectives

Witty¹,

Branney²,

Evans³

et al. 2013

European Journal of Oncology Nursing

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Purpose: Penile cancer is a rare but highly treatable condition. Whilst over 80% survive for over five years, treatment can have a significant impact on quality of life. There has been little research conducted to date on men's experiences of treatment for penile cancer; The Patients Experiences of Penile Cancer study (PEPC) aimed to redress this shortfall by exploring men's experiences of surgical treatment for penile cancer.Method: Data were collected using two methods; an initial narrative oral history followed by a semistructured interview. Maximum variation sampling was used to acquire the widest possible range of experiences. Twenty-seven interviews were conducted with men with an average age of 63 years at diagnosis (range = 41 -82). The data were analysed using constant comparison analysis. Results:The physical impact of surgery was inter-connected with broader events in the lives of the men experiencing treatment. These experiences cover urinary function, sexual function and sexual relationships, healing and recovery, masculinity, mental well-being, coping and support. Conclusions:A key area for the development of care is to devise and evaluate procedures for ensuring that men are well-informed about the extent and potential consequences of their treatment. Men's experiences of penile cancer surgery will be informed by a complex web interlaced with their broader life making it difficult for health professionals to judge how surgery will impact on a men presenting to them. Further research is required to ascertain the most appropriate strategies for rehabilitation of men experiencing penile cancer surgery.

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“…These two studies, taken together have led to a view that the more radical the penile surgery, the greater the effect on sexual function, with even partial penectomy having significant adverse effects. A more conservative approach using treatment modalities such as laser therapy, brachytherapy or conservative surgery such as glans resurfacing or glansectomy has recently been advocated (1,2). While the potential benefits of using a more conservative surgical approach has not been fully evaluated the effects of laser therapy for early stage tumours has been investigated in some detail (6).…”

Section: Quality Of Lifementioning

confidence: 99%

“…In treating the primary tumour, the standard of care is to provide a surgical cure (ie excising the tumour and a margin of normal penile tissue) while maintaining the function of the penis. The traditional view was that at least a 2cm margin of normal tissue should be removed, but there are recent publications that suggest that more conservative surgery may be safe (1,2). The advantage of such organ preserving surgery is intuitively advantageous to the patient, in that penile function can be better preserved, but the evidence to support this view is, at present, limited.…”

mentioning

confidence: 99%