Reconstruction of traumatic bone loss using the induced membrane technique: preliminary results about 11 cases

Kombate, Noufanangue Kanfitine; Walla, A; Ayouba, G; Bakriga, Batarabadja; Dellanh, Yaovi Yannick; Abalo, Anani; Dossim, Assang

doi:10.1016/j.jor.2017.06.009

Cited by 15 publications

(10 citation statements)

References 12 publications

(19 reference statements)

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“…Finally, 14 reports of individual patient data (90 patients) were utilized in this study. Additional patient information was not obtained from the authors of any of the studies 10,23–35 . The selection process flowchart is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

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Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta‐Analysis of Individual Participant Data

Lai

et al. 2022

Orthopaedic Surgery

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Several modifications of the induced membrane technique (IMT) have been reported, but there is no consensus regarding their results and prognosis. Moreover, most studies have focused on tibial defects; no meta‐analysis of the treatment of femoral defects using the IMT has been reported. This systematic review and meta‐analysis aimed to identify the potential risk factors of post‐procedural complications following the treatment of segmental femoral defects using the IMT. A comprehensive search was performed on the Cochrane Library, EBSCO, EMBASE, Ovid, PubMed, Scopus, and Web of Science databases, using the keywords “femur,” “Masquelet technique,” and “induced membrane technique.” Original articles composed in English, having accessible individual patient data, and reporting more than two cases of bony defect or nonunion of femur or more than five cases of any body part were included. Post‐procedural bone graft infections, final union status, and union time after second‐stage operation were analyzed. Fourteen reports, including 90 patients, were used in this study. External fixation in second‐stage surgery had an odds ratio of 9.267 for post‐procedural bone graft infection (p = 0.047). The odds ratio of post‐procedural bone graft infection and age >65 years for final non‐union status was 51.05 (p = 0.003) and 9.18 (p = 0.042). Shorter union time was related to impregnated antibiotics in the spacer (p = 0.005), transplanting all‐autologous grafts (p = 0.042), and the application of intramedullary nails as the second‐stage fixation method (p = 0.050). The IMT appears to be reasonable and reproducible for femoral segmental bone defects. Several preoperative and surgical factors may affect post‐procedural complications and union time.

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Section: Resultsmentioning

confidence: 99%

“…Additional patient information was not obtained from the authors of any of the studies. 10 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 The selection process flowchart is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta‐Analysis of Individual Participant Data

Lai

et al. 2022

Orthopaedic Surgery

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“…Recently, the induced membrane technique or Masquelet technique has been used to treat large bone defects. It is a two-step procedure: first, radical soft tissue and bone debridement are undertaken, then a cement spacer of polymethyl methacrylate (PMMA) is placed at the site of the bone defect and is stabilized with an external fixator [30,31]. The cement spacer prevents fibrous tissue invasion of the defect and induces the surrounding membrane hat will promote the revascularization of the bone graft [32,33].…”

Section: Treatments For Bone Lesionsmentioning

confidence: 99%

Scaffolds and coatings for bone regeneration

Pereira

Cengiz

Silva

et al. 2020

J Mater Sci: Mater Med

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Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects (<6 mm) and clinical intervention is needed for critical-size defects and beyond that along with non-union bone fractures and bone defects larger than critical size represent a major healthcare problem. Autografts are, still, being used as preferred to treat large bone defects. Mostly, due to the presence of living differentiated and progenitor cells, its osteogenic, osteoinductive and osteoconductive properties that allow osteogenesis, vascularization, and provide structural support. Bone tissue engineering strategies have been proposed to overcome the limited supply of grafts. Complete and successful bone regeneration can be influenced by several factors namely: the age of the patient, health, gender and is expected that the ideal scaffold for bone regeneration combines factors such as bioactivity and osteoinductivity. The commercially available products have as their main function the replacement of bone. Moreover, scaffolds still present limitations including poor osteointegration and limited vascularization. The introduction of pores in scaffolds are being used to promote the osteointegration as it allows cell and vessel infiltration. Moreover, combinations with growth factors or coatings have been explored as they can improve the osteoconductive and osteoinductive properties of the scaffold. This review focuses on the bone defects treatments and on the research of scaffolds for bone regeneration. Moreover, it summarizes the latest progress in the development of coatings used in bone tissue engineering. Despite the interesting advances which include the development of hybrid scaffolds, there are still important challenges that need to be addressed in order to fasten translation of scaffolds into the clinical scenario. Finally, we must reflect on the main challenges for bone tissue regeneration. There is a need to achieve a proper mechanical properties to bear the load of movements; have a scaffolds with a structure that fit the bone anatomy. Graphical Abstract* Helena Filipa Pereira

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“…Due to the periosteum-like membrane surrounding the defect, relatively large bone defects can be treated with less autologous bone compared to conventional autologous bone grafts. However, the induced membrane technique requires a two-stage procedure, and the amount of bone defect that can be regenerated remains limited [35].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration

Aoki

2020

Pharmaceutics

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Regenerative medicine has been widely researched for the treatment of bone defects. In the field of bone regenerative medicine, signaling molecules and the use of scaffolds are of particular importance as drug delivery systems (DDS) or carriers for cell differentiation, and various materials have been explored for their potential use. Although calcium phosphates such as hydroxyapatite and tricalcium phosphate are clinically used as synthetic scaffold material for bone regeneration, biodegradable materials have attracted much attention in recent years for their clinical application as scaffolds due their ability to facilitate rapid localized absorption and replacement with autologous bone. In this review, we introduce the types, features, and performance characteristics of biodegradable polymer scaffolds in their role as DDS for bone regeneration therapy.

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Reconstruction of traumatic bone loss using the induced membrane technique: preliminary results about 11 cases

Abstract: The induced membrane technique is an excellent option for bone defect reconstruction compared to other usual bone graft techniques. It helped us to manage large bone loss in various skeletal segments.

Cited by 15 publications

References 12 publications

Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta‐Analysis of Individual Participant Data

Induced Membrane Technique for the Management of Segmental Femoral Defects: A Systematic Review and Meta‐Analysis of Individual Participant Data

Scaffolds and coatings for bone regeneration

Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration

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