Reconstruction of parodontal tissue with chitosan

Müzzarelli, Riccardo A.A.; Biagini, G.; Pugnaloni, Armanda; Filippini, Oscar; Baldassarre, V.; Castaldini, C.; Rizzoli, C

doi:10.1016/0142-9612(89)90113-0

Cited by 178 publications

(99 citation statements)

References 18 publications

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“…30,31,[38][39][40][41][42][43][44][45][46][47] Such ionogels have been found to be suitable for an array of electrochemical applications. 38,46 Therefore, in addition to the preparation of AG-CH composites, we have attempted to prepare AG-CH-IL composite ionogels using a high solvating ability IL, 3 ) with a purity of 98% mass fraction was purchased from SD FINE CHEM, Mumbai. The molecular structure of IL and repeating units of agarose and chitosan is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Because of its biodegradable, biocompatible, non-toxic, antimicrobial and metal-binding properties, CH has been widely studied in chemical, biochemical and biomedical fields, and is extensively used in pharmaceutical and biomedical fields for controlled release of drugs, wound management, space filling implants, etc. [3][4][5] Since CH is a good interacting polymer having amine groups, it can combine or interact with an AG hydroxyl group to form an AG-CH complex, forming environmentally safe composite materials with combined advantages suitable for different applications. [6][7][8] However, the preparation of composites of these biopolymers in water or common organic solvents under mild conditions is not an easy process due to the presence of many hydroxyl groups, intra-and intermolecular hydrogen bonding and molecular close chain packing which creates difficulties in their effective solubilization.…”

Section: Introductionmentioning

confidence: 99%

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Facile preparation of agarose–chitosan hybrid materials and nanocomposite ionogels using an ionic liquid via dissolution, regeneration and sol–gel transition

2014

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We report simultaneous dissolution of agarose (AG) and chitosan (CH) in varying proportions in an ionic liquid (IL), 1-butyl-3-methylimidazolium chloride [C 4 mim] [Cl]. Composite materials were constructed from AG-CH-IL solutions using the antisolvent methanol, and IL was recovered from the solutions. Composite materials could be uniformly decorated with silver oxide (Ag 2 O) nanoparticles (Ag NPs) to form nanocomposites in a single step by in situ synthesis of Ag NPs in AG-CH-IL sols, wherein the biopolymer moiety acted as both reducing and stabilizing agent. Cooling of Ag NPs-AG-CH-IL sols to room temperature resulted in high conductivity and high mechanical strength nanocomposite ionogels. The structure, stability and physiochemical properties of composite materials and nanocomposites were characterized by several analytical techniques, such as Fourier transform infrared (FTIR), CD spectroscopy, differential scanning colorimetric (DSC), thermogravimetric analysis (TGA), gel permeation chromatography (GPC), and scanning electron micrography (SEM). The result shows that composite materials have good thermal and conformational stability, compatibility and strong hydrogen bonding interactions between AG-CH complexes. Decoration of Ag NPs in composites and ionogels was confirmed by UV-Vis spectroscopy, SEM, TEM, EDAX and XRD. The mechanical and conducting properties of composite ionogels have been characterized by rheology and current-voltage measurements. Since Ag NPs show good antimicrobial activity, Ag NPs -AG-CH composite materials have the potential to be used in biotechnology and biomedical applications whereas nanocomposite ionogels will be suitable as precursors for applications such as quasi-solid dye sensitized solar cells, actuators, sensors or electrochromic displays.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Facile preparation of agarose–chitosan hybrid materials and nanocomposite ionogels using an ionic liquid via dissolution, regeneration and sol–gel transition

2014

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“…İlk olarak 1811 yılında mantarlarda keşfedilmiş daha sonra 1830 lu yıllarda böceklerden izole edilmiştir ve 1859 yılında ise C. Rouget kitozanı keşfetmiştir. [1][2][3][4][5] Kitin (2-asetamid-2-deoksi-β-D-glukoz) doğada yaygın bulunan biyopolimer olup yapısal olarak selüloza benzerdir. Deniz eklem bacaklılarının dış iskeletlerinde, böceklerin epidermislerinde ve mantarların hücre duvarlarında bulunur.…”

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“…Kitozan cerrahi yaralarda iyileşmeyi hızlandırıp ve skar oluşumunu azaltarak yara iyileşmesine katkıda bulunur. 3,23,24 Yara iyileşmesini ve kapanmasını hızlandıran kitozan filmleri, hidrojelleri, süspansiyonları, çözeltileri ve yara örtüleri hazırlanmaktadır. 15 Kitozanın yara tedavisinde kullanılabilmesini sağlayan önemli özellikleri şunlardır: yara iyileşmesini hızlandırır, rahat ve ağrısız olarak yara yüzeyinin korunmasını sağlar, hijyenik olmayan koşullarda da kullanışlıdır, antibiyotik kullanımını gerektirmez ve operasyonları kolaylaştırır.…”

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Di̇ş Heki̇mli̇ği̇nde Ki̇ti̇n Ve Ki̇tozan

Oyar¹

2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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“…The glucosamine backbone produced by the N-deacetylation process gives chitosan a polycationic character. Because of these positive charges, such derivatives have been receiving much attention as potential candidates for use as a stimulant for regenerating oral soft tissues 15) and some blood coagulant factors 6) . Our previous study demonstrated that five chitin derivatives reduced the adsorption of oral streptococci onto saliva-treated hydroxyapatite and detached these bacteria from hydroxyapatite beads 20) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Molecular Mass and Degree of Deacetylation of Chitosan on Adsorption of Streptococcus sobrinus 6715 to Saliva Treated Hydroxyapatite.

Sano

Shibasaki

Mutoh

et al. 2002

Bull. Tokyo Dent. Coll.

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We evaluated the influence of molecular mass and degree of deacetylation of chitosan on the adsorption of Streptococcus sobrinus 6715 to saliva-treated hydroxyapatite (S-HA) by measuring the optical density of the bacterial cell suspensions released from saliva-treated hydroxyapatite. Twenty-five chitosan samples with different molecular masses (0.8-6 kDa) and degrees of deacetylation (10-95%) were prepared for the study. We found that the inhibition of adsorption of S. sobrinus 6715 to S-HA correlated positively with the molecular mass of chitosan (R‫)678.0ס‬ and that the optimal degree of deacetylation was 50-60% for maximum inhibition of bacterial binding to S-HA. We also examined the effect of chitosan on zeta potentials of the oral bacteria and their surface hydrophobicities. It was observed that chitosan reduced the magnitude of the zeta potential and surface hydrophobicities of the oral bacteria. Thus, the results demonstrated that chitosan with a molecular mass of 5-6 kDa and a degree of deacetylation of 50-60% might have the potential to act as an effective anti-plaque agent because of its polycationic properties.

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Reconstruction of parodontal tissue with chitosan

Cited by 178 publications

References 18 publications

Facile preparation of agarose–chitosan hybrid materials and nanocomposite ionogels using an ionic liquid via dissolution, regeneration and sol–gel transition

Facile preparation of agarose–chitosan hybrid materials and nanocomposite ionogels using an ionic liquid via dissolution, regeneration and sol–gel transition

Di̇ş Heki̇mli̇ği̇nde Ki̇ti̇n Ve Ki̇tozan

Effect of Molecular Mass and Degree of Deacetylation of Chitosan on Adsorption of Streptococcus sobrinus 6715 to Saliva Treated Hydroxyapatite.

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