Facile preparation of agarose–chitosan hybrid materials and nanocomposite ionogels using an ionic liquid via dissolution, regeneration and sol–gel transition

Trivedi, Tushar J.; Rao, K. Srinivasa; Kumar, Arvind

doi:10.1039/c3gc41317a

Cited by 89 publications

(84 citation statements)

References 70 publications

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“…This strong interaction can result in the formation of additional cross links which can restrict the entry of water. Our results were in accordance with what has been previously observed [18,38]. The strong water retaining capacity of the synthesized scaffolds could be attributed to their hydrophilicity and a 3-D architecture.…”

Section: Swelling Testsupporting

confidence: 92%

“…This can be due to the amorphous nature of agarose. XRD pattern for silver nitrate shows distinct diffraction peaks at around 25 , 37 , 45 , 70 and 76 which are characteristics of (110), (111), (200), (220) and (311) planes of Face centred cubic (FCC) silver, respectively [18,34]. Presence of peak at 2h ¼ 20 Figure 2.…”

Section: Synthesis and Characterization Of Ag-chnp Scaffoldsmentioning

confidence: 98%

“…The presence of combination of functional groups from both the polymers is clearly visible in spectrum of all the four AG-CHNp scaffolds. The presence of peak at around 1645 cm À1 (C¼N) can be attributed to glutaraldehyde crosslinking within the composite [18,35].…”

Section: Synthesis and Characterization Of Ag-chnp Scaffoldsmentioning

confidence: 99%

“…Chitosan blended with other polymers have been used in regeneration of almost all the organs including liver, kidney, pancreatic islets, heart, bone, etc. [18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible agarose-chitosan coated silver nanoparticle composite for soft tissue engineering applications

Kumar

Desagani

Chandran

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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With increasing gap in the demand and supply of vital organs for transplantation there is a pressing need to bridge the gap with substitutes. One way to make substitutes is by tissue engineering which involves combining several types of synthetic or biomaterials, cells and growth factors cross-linked together to synthesize a functional scaffold for repair or replacement of non-functional organs. Nanoparticle based composites are gaining importance in tissue engineering due to their ability to enhance cell attachment and proliferation. The current study focuses on synthesizing agarose composites embedded with chitosan-coated silver nanoparticles using glutaraldehyde as the cross-linker. The synthesis of chitosan coated silver nanoparticles within the scaffold was confirmed with UV-visible spectroscopy. Physical and chemical characterization of the synthesized nanoparticles were done by XRD, FTIR, TGA and SEM. DMA showed higher mechanical strength of the scaffolds. The scaffolds showed degradation of ∼37% within a span of four weeks. The higher physical support provided by the synthesized scaffolds was shown by in-vitro cell viability assay. Broad spectrum anti-bacterial activity and superior hemocompatibility further showed the advantage it offered for growing cells. Thus a biopolymer based nanocomposite was synthesized, with intended widespread use as scaffold for engineering of soft tissues due to its enhanced biocompatibility and greater surface area for cell growth.

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Section: Swelling Testsupporting

confidence: 92%

Section: Synthesis and Characterization Of Ag-chnp Scaffoldsmentioning

confidence: 98%

Section: Synthesis and Characterization Of Ag-chnp Scaffoldsmentioning

confidence: 99%

“…Chitosan blended with other polymers have been used in regeneration of almost all the organs including liver, kidney, pancreatic islets, heart, bone, etc. [18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biocompatible agarose-chitosan coated silver nanoparticle composite for soft tissue engineering applications

Kumar

Desagani

Chandran

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…On the other hand, the characteristic absorption peaks at

\overset{ν}{true}

=1725 cm −1 for the C=O ester,

\overset{ν}{true}

=1234 and 743 cm −1 for the C−N carbamate stretching, and

\overset{ν}{true}

=1603 cm −1 for the phenyl skeleton confirmed the carbanilation of AG. Additionally, the main characteristic IR bands of agarose are also maintained after functionalization, which confirms the stable structure of the functionalized AG samples –. The expected conformation changes during the functionalization of AG in the IL were examined by comparing the circular dichroism (CD) spectra of native AG and modified AG.…”

Section: Resultsmentioning

confidence: 59%

Functionalized Agarose Self‐Healing Ionogels Suitable for Supercapacitors

et al. 2015

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Agarose has been functionalized (acetylated/carbanilated) in an ionic liquid (IL) medium of 1-butyl-3-methylimidazolium acetate at ambient conditions. The acetylated agarose showed a highly hydrophobic nature, whereas the carbanilated agarose could be dissolved in water as well as in the IL medium. Thermoreversible ionogels were obtained by cooling the IL sols of carbanilated agarose at room temperature. The ionogel prepared from a protic-aprotic mixed-IL system (1-butyl-3-methylimidazolium chloride and N-(2-hydroxyethyl)ammonium formate) demonstrated a superior self-healing property, as confirmed from rheological measurements. The superior self-healing property of such an ionogel has been attributed to the unique inter-intra hydrogen-bonding network of functional groups inserted in the agarose. The ionogel was tested as a flexible solid electrolyte for an activated-carbon-based supercapacitor cell. The measured specific capacitance was found to be comparable with that of a liquid electrolyte system at room temperature and was maintained for up to 1000 charge-discharge cycles. Such novel functionalized-biopolymer self-healing ionogels with flexibility and good conductivity are desirable for energy-storage devices and electronic skins with superior lifespans and robustness.

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