Reconstruction of Congenital Pseudarthrosis of the Clavicle with Use of the Masquelet Technique

Gouron, Richard; Deroussen, François; Juvet-Segarra, M.; Plancq, Marie-Christine; Collet, Louis-Michel

doi:10.2106/jbjs.cc.l.00095

Cited by 19 publications

(9 citation statements)

References 16 publications

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“…Bone union with complete integration of the graft and cortical reconstitution is achieved between 1 year and 2 years postoperatively, depending on the underlying disease. Initially developed in septic pseudarthrosis excision in adults, this reconstructive procedure has also been applied to traumatic bone loss, tumour resection and reconstruction (Biau et al ., ; Villemagne et al ., ; Chotel et al ., ), congenital pseudarthrosis of the tibia (Gouron et al ., ; Pannier et al ., ) and reconstruction of bone defects in children (Gouron et al ., , ).…”

Section: Introductionmentioning

confidence: 99%

Osteoclasts and their precursors are present in the induced-membrane during bone reconstruction using the Masquelet technique

Gouron

Petit

Boudot

et al. 2014

J Tissue Eng Regen Med

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In 2000, Masquelet reported a long bone reconstruction technique using an induced membrane formed around a polymethylmethacrylate (PMMA) spacer placed in the defect with appropriate stabilization followed by secondary bone graft after PMMA removal. This reconstruction procedure allows rapid and safe bone reformation for septic, traumatic, neoplastic or congenital bone defects. A rat model of the Masquelet technique was developed to further characterize the biological activities of this induced membrane. Our model allows healing of a critical-sized femoral defect (8 mm) by means of this procedure over a period of 18 weeks. Comparison of induced membranes obtained 3, 4, 5 and 6 weeks after PMMA insertion indicated that this tissue changes over time. Several mineralization spots and bone cells were observed in contact with the PMMA, when assessed by Alizarin Red, Von Kossa, Alkaline phosphatase and Tartrate-resistant acid phosphatase staining of the membranes. CTR (calcitonin receptor)- and RANK (Receptor Activator of Nuclear factor Kappa B)- positive mononuclear cells were detected in the induced membrane, confirming the presence of osteoclasts in this tissue. These cells were observed in a thin, highly cellular layer in the induced membrane in contact with the PMMA. Together, these findings suggest that the membrane is able to promote osteointegration of autologous corticocancellous bone grafts during the Masquelet technique by creating local conditions that may be favourable to graft bone remodelling and osteointegration. Copyright © 2014 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Osteoclasts and their precursors are present in the induced-membrane during bone reconstruction using the Masquelet technique

Gouron

Petit

Boudot

et al. 2014

J Tissue Eng Regen Med

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“…The 11 patients of our study had a mean follow-up of 6.54 months (3)(4)(5)(6)(7)(8)(9)(10)(11). Radiological healing was observed in 6 patients (4 femurs and 2 humerus).…”

Section: Resultsmentioning

confidence: 98%

“…This technique is already done worldwide in traumatic bone loss, 7,8 and its indications have been extended to non-traumatic bone loss. [9][10][11] Several series have been reported in order to assess the results of this technique. The largest series reported 84 patients (43 recent lesions and 41 non-unions) with a healing rate of 90%, and no failure was reported for recent lesions.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of traumatic bone loss using the induced membrane technique: preliminary results about 11 cases

Kombate¹,

Walla

Ayouba

et al. 2017

Journal of Orthopaedics

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“…Only one case of CPC treated by the Masquelet technique has been reported by Gouron et al 2 who assert that this method avoids the disadvantages of plate fixation and can be used in case of surgical revision after massive lysis of the bone graft.…”

Section: Discussionmentioning

confidence: 99%

Congenital pseudarthrosis of the clavicle treated by Masquelet technique

Abdellaoui¹,

Atarraf

Chater

et al. 2017

BMJ Case Reports

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Congenital pseudarthrosis of the clavicle (CPC) is a very rare pathology of which over 200 cases have been reported. Usually discovered during the first months of life, CPC is characterised by a definitive bone defect in the middle third of the clavicle. Generally asymptomatic, the pseudarthrosis of the clavicle can cause aesthetic issues and functional symptoms indicating a surgical repair. Different reconstruction techniques have been reported with various complications. We present a 14-year-old boy diagnosed with CPC and concerned about the cosmetic aspect of a swelling of his right clavicle. We performed a two-stage surgical repair using the induced membrane technique described by Masquelet. A complete bone union has been obtained, and patient is satisfied with the cosmetic appearance. In our opinion, the Masquelet technique is a safe and reproducible procedure to treat CPC in high-risk older patients with long gap allowing a rapid and lasting bone union.

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Reconstruction of Congenital Pseudarthrosis of the Clavicle with Use of the Masquelet Technique

Cited by 19 publications

References 16 publications

Osteoclasts and their precursors are present in the induced-membrane during bone reconstruction using the Masquelet technique

Osteoclasts and their precursors are present in the induced-membrane during bone reconstruction using the Masquelet technique

Reconstruction of traumatic bone loss using the induced membrane technique: preliminary results about 11 cases

Congenital pseudarthrosis of the clavicle treated by Masquelet technique

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