Reconstructed silk fibroin mediated smart wristband for physiological signal detection

Zhang, Yifan; Patil, Aniruddha; Hou, Chen; Lu, Di; Qiu, Wei; Kong, Lingqing; Wu, Ronghui; Ma, Liyun; Yu, Rui; Yu, Weidong; Liu, Xiang Yang

doi:10.1016/j.cej.2021.132362

Cited by 19 publications

(19 citation statements)

References 35 publications

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“…(a) Variation curve of Δ I / I 0 with pressure. (b) Comparison among our work and other reported literature. ,,,,,− (c) Responsive time was measured with the weight-moving method. (d) The linear relation of the current–voltage curves suggests the ohmic contacts between MPN and Au electrodes.…”

Section: Results and Discussionmentioning

confidence: 75%

“…In the pressure region less than 8 kPa, the sensitivity can be obtained as 35.02 kPa –1 and decreases to 7.31 kPa –1 in the range of 8–18 kPa. To the best of our knowledge, our device achieved the best performance among the pressure-sensing devices capable of pulse diagnosis reported in the literature in terms of both sensitivity and wide-range linearity (Figure b ,,,,,− ); the specific parameters are included in Table S1. The two insets of Figure c show the enlarged section of the time response curve, exhibiting an ultrafast response and recovery time of 6 ms. Figure d shows the current–voltage ( I – V ) curves of the device under various levels of static pressure, indicating an excellent pressure-sensing response.…”

Section: Results and Discussionmentioning

confidence: 99%

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Multichannel Flexible Pulse Perception Array for Intelligent Disease Diagnosis System

et al. 2023

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Pressure sensors with high sensitivity, a wide linear range, and a quick response time are critical for building an intelligent disease diagnosis system that directly detects and recognizes pulse signals for medical and health applications. However, conventional pressure sensors have limited sensitivity and nonideal response ranges. We proposed a multichannel flexible pulse perception array based on polyimide/multiwalled carbon nanotube–polydimethylsiloxane nanocomposite/polyimide (PI/MPN/PI) sandwich-structure pressure sensor that can be applied for remote disease diagnosis. Furthermore, we established a mechanical model at the molecular level and guided the preparation of MPN. At the structural level, we achieved high sensitivity (35.02 kPa–1) and a broad response range (0–18 kPa) based on a pyramid-like bilayer microstructure with different upper and lower surfaces. A 27-channel (3 × 9) high-density sensor array was integrated at the device level, which can extract the spatial and temporal distribution information on a pulse. Furthermore, two intelligent algorithms were developed for extracting six-dimensional pulse information and automatic pulse recognition (the recognition rate reaches 97.8%). The results indicate that intelligent disease diagnosis systems have great potential applications in wearable healthcare devices.

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Section: Results and Discussionmentioning

confidence: 75%

Section: Results and Discussionmentioning

confidence: 99%

Multichannel Flexible Pulse Perception Array for Intelligent Disease Diagnosis System

et al. 2023

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Section: ■ Introductionmentioning

confidence: 99%

“…Electronic skin, a flexible and wearable electronic system that mimics the functional and mechanical properties of biological skin, has received increasing attention in recent years , due to its wide applications in wearable devices, robots, human–machine interaction (HMI), artificial muscles, artificial organs, and monitoring sensors. − The flexible sensors can act as electronic skin, composed of hydrogel , and film shapes. , However, in general, hydrogels have poor water retention and low mechanical strength, , which considerably and significantly limits their real-time responses as flexible sensors to signals such as strain and temperature . Existing film-based flexible material sensing materials include the most widely used poly(tetrafluoroethylene) (PTFE), poly(dimethylsiloxane) (PDMS), polyimide, fluorinated ethylene propylene, and silicone rubber .…”

Section: Introductionmentioning

confidence: 99%

Intrinsically Conductive Bifunctional Nanocellulose-Reinforced Robust and Self-Healable Electronic Skin: Deep Insights into Multiple Bonding Network, Property Reinforcement, and Sensing Mechanism

Miao

et al. 2022

ACS Sustainable Chem. Eng.

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The rapid development of intelligent electronic skin with skin-like protein structures and noninvasive adhesion to the skin has attracted attention in the field of wearable electronics. However, poor mechanical strength, narrow sensing range, and low adhesion hinder its practical applications. Herein, a multifunctional composite sensor (SCGC) was achieved by incorporating an intrinsically conductive bifunctional nanocellulose (CNFene) into a Ca 2+ /glycerin (GL)-modified silk fibroin (SF) matrix. The SCGC film showed robust mechanical strength (tensile strength = 76.1 MPa, elongation at break = 144.2%), wide sensing range, and excellent self-adhesion ability (strong adhesion at low temperatures even in liquid nitrogen). Especially, the bifunctional nanocellulosereinforced electronic skin can sensitively detect small-and largescale human motion and has high-temperature change sensitivity (the temperature sensitivity = −5.2%/°C) due to multiple interactions of the double hydrogen-bonding network and calcium ion chelation among SF/CNFene/GL/Ca 2+ . Therefore, this strategy has potential applications in flexible electrodes, biomimetic sensors, and temperature biosensors.

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“…Generally, SF-based materials are modified or functionalized to achieve the required performance of the specific electronic devices. The most commonly used methods for the modification of SF materials include the mixed method, physical deposition of metal method, chemical cross-linking method, , and carbonization method . Among them, chemical cross-linking is the most commonly used method for optimizing the mechanical properties of SF-based materials.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Crosslinked Silk Fibroin Hydrogel for Biodegradable Electronic Skin and Pulse Waveform Measurements

et al. 2022

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The development of a portable, controllable, and environmentally friendly electronic skin (e-skin) is highly desirable; however, it presents a major challenge. Herein, a biocompatible, biodegradable, and easily usable hydrogel was designed and fabricated as e-skin to enable the transmission of information regarding the spatial pressure distribution. Silk fibroin (SF) was used as the hydrogel skeleton, which endowed the hydrogel with intelligent mechanical sensitivity. During its conditioning in weakly acidic media, the density of the enzymatic crosslink increased and a dense network was formed due to the formation of covalent/hydrogen bonds. Additionally, a conductive SF/polyvinyl alcohol (PVA) hybrid film was molded as a flexible electrode after graphite deposition. The above SF sensing unit based on SF hydrogels and SF/PVA hybrid films showed high strain sensitivity (4.78), fast responsiveness (<0.1 s), good cycling stability (≥10,000), excellent biocompatibility, and biodegradability. Importantly, a coplanar 8 × 8 pixel SF-based e-skin array was successfully fabricated and applied for 3D signal transmission of the object. The SF-based e-skin was capable of precisely tracking the changes in the pulse pressure, the movement of the finger joint, and the vibrations of the vocal cord. Therefore, the current findings provide a solid foundation for future studies exploring the next generation of electronic devices.

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Reconstructed silk fibroin mediated smart wristband for physiological signal detection

Cited by 19 publications

References 35 publications

Multichannel Flexible Pulse Perception Array for Intelligent Disease Diagnosis System

Multichannel Flexible Pulse Perception Array for Intelligent Disease Diagnosis System

Intrinsically Conductive Bifunctional Nanocellulose-Reinforced Robust and Self-Healable Electronic Skin: Deep Insights into Multiple Bonding Network, Property Reinforcement, and Sensing Mechanism

Enzymatic Crosslinked Silk Fibroin Hydrogel for Biodegradable Electronic Skin and Pulse Waveform Measurements

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