Multichannel Flexible Pulse Perception Array for Intelligent Disease Diagnosis System

Abstract

Pressure sensors with high sensitivity, a wide linear range, and a quick response time are critical for building an intelligent disease diagnosis system that directly detects and recognizes pulse signals for medical and health applications. However, conventional pressure sensors have limited sensitivity and nonideal response ranges. We proposed a multichannel flexible pulse perception array based on polyimide/multiwalled carbon nanotube–polydimethylsiloxane nanocomposite/polyimide (PI/MPN/PI) sandwich-structure pressure sensor that can be applied for remote disease diagnosis. Furthermore, we established a mechanical model at the molecular level and guided the preparation of MPN. At the structural level, we achieved high sensitivity (35.02 kPa–1) and a broad response range (0–18 kPa) based on a pyramid-like bilayer microstructure with different upper and lower surfaces. A 27-channel (3 × 9) high-density sensor array was integrated at the device level, which can extract the spatial and temporal distribution information on a pulse. Furthermore, two intelligent algorithms were developed for extracting six-dimensional pulse information and automatic pulse recognition (the recognition rate reaches 97.8%). The results indicate that intelligent disease diagnosis systems have great potential applications in wearable healthcare devices.

Pressure and Temperature Dual-Parameter Sensor Based on Natural Wood for Portable Health-Monitoring Devices

“…When the pressure continues to rise, the Seebeck coefficient decreases. It is attributed to the fact that the densification caused by high pressure will change the thermal conductivity of the sensor, thus adversely affecting the Seebeck coefficient (Figure d) Figure c shows that the pressure sensitivity will change significantly when the temperature difference is higher than 15 K. It can be explained by the variable-range hopping transport mechanism, which facilitates the mobility of charge carriers at higher temperatures and hence enhances electrical conductance, as shown in Figure e .…”

“…In addition, these medical devices carry high cost, inconvenient usage, and poor portability, which will seriously hinder the continuity and comprehensiveness of vital sign monitoring. , Therefore, developing portable, low-power-consumption, and bifunctional sensors for continuous and real-time monitoring of pulse waves and body temperature is essential for ensuring postoperative patients’ life safety and recovery. Various pressure sensors have recently been proposed to monitor pulse waves and blood pressure to diagnose and prevent cardiovascular disease. − However, the lack of body temperature detection makes them unable to fully monitor the vital signs of postoperative patients clinically. By improving the structure , and introducing thermoelectric materials, − some pressure sensors can also detect the temperature accurately.…”

Recent Advancements in Physiological, Biochemical, and Multimodal Sensors Based on Flexible Substrates: Strategies, Technologies, and Integrations

“…For example, the combination of tactile sensors and pattern recognition can realize an intelligent robot’s gesture control or direct control . Today it is already possible to combine the physiological information on the human body to achieve intelligent disease diagnosis . If the application of multimodal sensors is assembled, intelligent body diagnosis will become possible through richer information fusion and algorithm processing.…”

“…238 Today it is already possible to combine the physiological information on the human body to achieve intelligent disease diagnosis. 239 If the application of multimodal sensors is assembled, intelligent body diagnosis will become possible through richer information fusion and algorithm processing. (3) The devices can also synchronize detection and treatment by integrating functional treatment parts.…”

Synergetic Monitoring of both Physiological Pressure and Epidermal Biopotential Based on a Simplified on‐Skin‐Printed Sensor Modality

“…For example, artery pulse signals arising from heartbeat are closely related to the cardiovascular states. [48][49][50] Synergistic monitoring of both bioelectrical signals and physiological pressure can provide more comprehensive and detailed information on human health conditions. Conventionally, bioelectrical signals and physiological pressure are typically detected with separate sensing devices.…”