Reconnecting exposure, toxicokinetics and toxicity in food safety: OpenFoodTox and TKplate for human health, animal health and ecological risk assessment

Dorne, Jean Lou; Amzal, Billy; Quignot, Nadia; Więcek, Witold; Grech, Audrey; Brochot, Céline; Beaudouin, Rémy; Ragas, A.M.J.; Lautz, L.S.; Oldenkamp, Rik; Béchaux, Camille; Darney, K.; Kramer, Nynke I.; Kasteel, Emma E.J.; Testai, Emanuela; Turco, Laura; Vichi, Susanna; Buratti, Franca M.; Consiglio, Emma Di; Baas, Jan; Augustine, Sarah; Marques, Gustavo Henrique; Kass, George E.N.; Reilly, Linda M.; Richardson, Jane; Gilsenan, Mary B.; Dujardin, Bruno; Verhagen, Hans; Seze, Guilhem De; Spyropoulos, Demetri D.; Nougadère, Alexandre; Cortinas-Abrahantes, J.; Livaniou, A.; Manini, Paola; Verloo, Didier; Bassan, Arianna; Ceriani, Lidia; Pavan, Manuela; Tebby, Cléo; Benfenati, Emilio; Paini, Alicia; Liem, Djien; Robinson, Tobin

doi:10.1016/j.toxlet.2018.06.1128

Cited by 2 publications

(1 citation statement)

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“…EFSA has developed a chemical hazards database “OpenFoodTox 2.0” and funded collaborative research to develop generic toxicokinetic and toxicodynamic human and animal models to predict the toxicity of chemicals ( Dorne et al, 2018 ; Benfenati et al, 2020 ). Further, in 2019, EFSA published their opinion on the use of in vitro comparative metabolism (IVCM) studies for use in pesticide risk assessment ( EFSA, 2019 ).…”

Section: Pesticides and Plant Protection Productsmentioning

confidence: 99%

Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of industrial chemicals and pesticides for effects on human health

Stucki¹,

Barton-Maclaren

Bhuller

et al. 2022

Front. Toxicol.

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New approach methodologies (NAMs) are increasingly being used for regulatory decision making by agencies worldwide because of their potential to reliably and efficiently produce information that is fit for purpose while reducing animal use. This article summarizes the ability to use NAMs for the assessment of human health effects of industrial chemicals and pesticides within the United States, Canada, and European Union regulatory frameworks. While all regulations include some flexibility to allow for the use of NAMs, the implementation of this flexibility varies across product type and regulatory scheme. This article provides an overview of various agencies’ guidelines and strategic plans on the use of NAMs, and specific examples of the successful application of NAMs to meet regulatory requirements. It also summarizes intra- and inter-agency collaborations that strengthen scientific, regulatory, and public confidence in NAMs, thereby fostering their global use as reliable and relevant tools for toxicological evaluations. Ultimately, understanding the current regulatory landscape helps inform the scientific community on the steps needed to further advance timely uptake of approaches that best protect human health and the environment.

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Section: Pesticides and Plant Protection Productsmentioning

confidence: 99%