Recommendations to control pertussis prioritized relative to economies: A Global Pertussis Initiative update

Forsyth, Kevin; Tan, Tina Q.; König, Carl Heinz Wirsing von; Heininger, Ulrich; Chitkara, A. J.; Plotkin, Stanley А.

doi:10.1016/j.vaccine.2018.10.028

Cited by 32 publications

(22 citation statements)

References 40 publications

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“…Notification rates are dependant on the use of diagnostics, reporting and ascertainment per country and therefore do not reflect the real incidence numbers. In response to continued pertussis disease, many countries have adopted an accelerated schedule of primary series vaccinations and all western countries have implemented booster vaccinations in childhood [27,28]. In addition, some countries introduced extra aP boosters for adolescents and adult target populations, including pregnant women, military conscripts, healthcare workers, and older adults [29À34].…”

Section: Introductionmentioning

confidence: 99%

Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom

et al. 2021

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Background: Pertussis can lead to serious disease and even death in infants. Older adults are more vulnerable to complications as well. In high-income countries, acellular pertussis vaccines are used for priming vaccination. In the administration of booster vaccinations to different age groups and target populations there is a substantial between-country variation. We investigated the effect of age on the response to acellular pertussis booster vaccination in three European countries. Methods: This phase IV longitudinal intervention study performed in Finland, the Netherlands and the United Kingdom between October 2017 and January 2019 compared the vaccine responses between healthy participants of four age groups: children (7À10y), adolescents (11À15y), young adults (20À34y), and older adults (60À70y). All participants received a three-component acellular pertussis vaccine. Serum IgG and IgA antibody concentrations to pertussis antigens at day 0, 28, and 1 year were measured with a multiplex immunoassay, using pertussis toxin concentrations at day 28 as primary outcome. This trial is registered with ClinicalTrialsRegister.eu (2016À003,678À42). Findings: Children (n = 109), adolescents (n = 121), young adults (n = 74), and older adults (n = 75) showed high IgG antibody concentrations to pertussis toxin at day 28 with GMCs of 147 (95% CI 120À181), 161 (95% CI 132À196), 103 (95% CI 80À133), and 121 IU/ml (95% CI 94À155), respectively. A significant increase in GMCs for vaccine antigens in all age groups by 28 days was found which had decreased by 1 year. Differences in patterns of IgG GMCs at 28 days and 1 year post-vaccination did not have a consistent relationship to age. In contrast, IgA antibodies for all antigens increased with age at all timepoints. Interpretation: Acellular pertussis booster vaccination induces significant serum IgG responses to pertussis antigens across the age range which are not uniformly less in older adults. Acellular boosters could be considered for older adults to reduce the health and economic burden of pertussis.

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Section: Introductionmentioning

confidence: 99%

Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom

et al. 2021

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“…The case-fatality rates in developing countries are estimated to be as high as 4% [16]. In 2015, more than half of all estimated pertussis-related deaths of children <5 years of age occurred in Africa [17]. In Ethiopia, as part the expanded immunization program (EPI) children are vaccinated for pertussis through DTP (diphtheria-pertussis-tetanus) given at 6 th , 10 th and 14 th weeks.…”

Section: Introductionmentioning

confidence: 99%

Pertussis outbreak investigation in Janamora district, Amhara Regional State, Ethiopia: a case-control study

Almaw¹,

Bizuneh²

2019

Pan Afr Med J

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IntroductionOn April 17/2017 Janamora district, Amhara regional state health officials reported an increasing number of people with a cough. The objectives of this study was to investigate the outbreak, describe risk factors and implement control measures.MethodsWe conducted a community based unmatched 1:1 case-control study April 22-May 10, 2017. We used a probable case definition (≥2 weeks cough with vomiting, apnea, or inspiratory whoop) to identify suspected pertussis cases. Neighbors of cases were considered as controls. We conducted a door-to-door active case search and reviewed medical records, assessed vaccination status by parental interview or vaccination card. We implemented multivariable logistic regression to identify independent factors associated with the outbreak.ResultsWe investigated 60 cases and 60 controls. Most (68.3%) of the cases were under the age of 15. The majority (86.6%) of pertussis suspected cases, and 83.4% controls had not received any pertussis vaccine. The overall attack rate was 0.13% and the case fatality rate was 3.3%. The age-specific attack rate for under-five children was 0.33%. Females were more likely to have pertussis (AOR: 2.91; 95% CI: 1.17-7.22), contact with pertussis suspected person (AOR: 6.29; 95% CI: 2.53-15.62) and living in a relatively poorly ventilated house (AOR: 3.01; 95% CI: 1.17-7.70) were also significant risk factors of pertussis.ConclusionWeak supplementary immunization activities might have contributed to the outbreak. Treating household contacts and integration of diagnostic laboratory test of pertussis into the local health system is of paramount importance to detect outbreaks early on.

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“…Because all the children were inoculated at 3 months (Huang et al, 2017), there was a group of children younger than 3 months. Pertussis is a threat to children, especially children under the age of five years (Forsyth et al, 2018), and infants younger than 12 months bear the greatest burden (Forsyth et al, Table 1 The inclusion criteria for suspected BP-Infection children in this study.…”

Section: Resultsmentioning

confidence: 99%

“…Pertussis is a vaccine-preventable disease that causes morbidity and mortality, particularly in infants and children under 5 years (Forsyth et al, 2018). Pertussis remains difficult to diagnose because of the variation in its clinical presentation and interference of pertussis-like illnesses (Frumkin, 2013;Wirsing von Koenig, 2014).…”

Section: Discussionmentioning

confidence: 99%

Severe Bordetella pertussis infection and vaccine issue in Chongqing, from 2012 to 2018

Liu

Shu

et al. 2019

International Journal of Infectious Diseases

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Objective: Pertussis is a highly contagious respiratory illness mainly caused by the Gram-negative bacterium Bordetella pertussis. The infection of B. pertussis has been increasing and the current diagnosis of pertussis in children is challenging; little is known of B. pertussis infection in Chongqing. Methods: There were 25,441 children (14,863 male and 10,578 female) with suspected pertussis enrolled in our retrospective study from December 2012 to November 2018. Then 800 children with suspected B. pertussis infection were randomly chosen to be evaluated by simultaneous amplification and testing in this prospective study. Results: Infants younger than 12 months had the greatest burden of pertussis, and the incidence of pertussis in Chongqing appeared to have a periodic pattern. The problem of vaccine quality in China was more serious than previously reported based on the fluctuation of infection rates from 2012 to 2018. Simultaneous amplification and testing to detect B. pertussis RNA (Area Under Curve: 0.900 and Kappa value: 0.831) had better diagnostic performance than real-time PCR for B. pertussis DNA (Area Under Curve: 0.869 and Kappa value: 0.690). Conclusions:We revealed the characteristics of B. pertussis infection and vaccine issues in Chongqing. Simultaneous amplification and testing could be a potential novel assay for measuring B. pertussis infection in the future.

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Recommendations to control pertussis prioritized relative to economies: A Global Pertussis Initiative update

Cited by 32 publications

References 40 publications

Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom

Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults: A collaborative study in Finland, the Netherlands, and the United Kingdom

Pertussis outbreak investigation in Janamora district, Amhara Regional State, Ethiopia: a case-control study

Severe Bordetella pertussis infection and vaccine issue in Chongqing, from 2012 to 2018

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