Recommendations of the Infectious Diseases Work Group (GTEI) of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) and the Infections in Critically Ill Patients Study Group (GEIPC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) for the diagnosis and treatment of influenza A/H1N1 in seriously ill adults admitted to the Intensive Care Unit

Rodríguez, Alejandro; Álvarez–Rocha, Luis; Sirvent, Josep Ma; Zaragoza, Rafael; Nieto, M.; Arenzana, A.; Luqué, Pilar; Socías, Lorenzo; Martín, María del Mar López; Navarro, David; Camarena, Juan J.; Lorente, Leonardo; Trefler, Sandra; Vidaur, Loreto; Solé‐Violán, Jordi; Barcenilla, Fernando Barroso; Pobo, Angel; Vallès, Jordi; Ferri, Cristina; Martín‐Loeches, Ignacio; Dı́az, Emili; López, Diego Pérez; López-Pueyo, M.J.; Gordo, Federico; Nogal, F. del; Marqués, A. Fe; Tormo, S.; Fuset, María Paz; Mur-Pérez, Francisco; Bonastre, Juan; Suberviola, Borja; Navas, Enrique; León, Cristóbal

doi:10.1016/j.medine.2012.03.002

Cited by 28 publications

(39 citation statements)

References 170 publications

(145 reference statements)

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“…BALF samples after treatment against influenza virus nucleic acid positive reflect viral activity and pathogenicity, disputed [9,10]. At this point, the isolation of influenza a virus and determine its activity [11]. Home to carry out the technique, refer to the incubation period of influenza viruses reasonably isolated.…”

Section: Discussionmentioning

confidence: 99%

Experience in Treatment of Patients with Severe Influenza with Viral Pneumonia in ICU

2017

JACCOA

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Objective: To explore the experience of severe influenza A viral pneumonia treatment. Methods:The clinical data and treatment of 6 cases of severe influenza with virus RNA-positive pneumonia were analyzed.Results: 3 cases of new H1N1 influenza, 3 cases did not do further nucleic acid subtype identification, patients were treated with oseltamivir. 3 patients with invasive pulmonary aspergillosis, 4 patients received invasive mechanical ventilation, 2 cases of pneumothorax. 3 patients received continuous hemofiltration for acute renal injury, 4 with ventilator-associated pneumonia in 5 patients with mechanical ventilation, and 5 patients died. Conclusion:Suffering from severe underlying disease, the use of glucocorticoids, deep sedation, secondary pulmonary infection of influenza A virus causes severe pneumonia and high mortality.

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Section: Discussionmentioning

confidence: 99%

Experience in Treatment of Patients with Severe Influenza with Viral Pneumonia in ICU

2017

JACCOA

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“…In particular, pregnant women who are infected with the influenza A(H1N1) virus can more easily suffer from dyspnea, hypoxemia, and acute respiratory distress syndrome, which may lead to miscarriage, premature delivery, fetal distress, or fetal intrauterine death (14,15). Viruses can induce an increase in the symptoms of underlying diseases, and in severe cases, these underlying diseases can lead to death.…”

Section: Discussionmentioning

confidence: 99%

Prospective Cohort Study of the Safety of an Influenza A(H1N1) Vaccine in Pregnant Chinese Women

Ma¹,

Zhang²,

Jiang³

et al. 2014

Clin. Vaccine Immunol.

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To monitor and evaluate the safety of the influenza A(H1N1) vaccine in pregnant women and its influence on the fetus and neonate, we performed a prospective study in which 122 pregnant Chinese women who received the influenza A(H1N1) vaccine and 104 pregnant women who did not receive any vaccine (serving as controls) were observed. The results indicated that the seroconversion rate in the vaccinated group was 90.4% (95% confidence interval [CI], 82.6% to 95.5%). The rate of adverse events following immunization in the pregnant women who received the influenza A(H1N1) vaccine was 3.3%. The spontaneous abortion rates in the vaccinated group and the unvaccinated group were 0.8% and 1.9%, respectively (exact probability test, P ‫؍‬ 0.470), the prolonged-pregnancy rates were 8.2% and 4.8%, respectively ( 2 ‫؍‬ 1.041, P ‫؍‬ 0.308), the low-birth-weight rates were 1.6% and 0.95%, respectively (exact probability test, P ‫؍‬ 1.000), and the spontaneous-labor rates were 70.5% and 75%, respectively ( 2 ‫؍‬ 0.573, P ‫؍‬ 0.449). All newborns who have an Apgar score of >7 are considered healthy; Apgar scores of >9 were observed in 38.5% and 57.7% of newborns in the vaccinated group and the unvaccinated group, respectively ( 2 ‫؍‬ 8.274, P ‫؍‬ 0.004). From these results, we conclude that the influenza A(H1N1) vaccine is safe for pregnant women and has no observed adverse effects on fetal growth. (This study has been registered at ClinicalTrials.gov under registration no. NCT01842997.)

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“…Lymphopenia, neutropenia and thrombocytopenia have been described as components of H1N1 infection . In recent studies, laboratory results were used for a quicker diagnose of H1N1 . Rodriguez et al .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation

Göktürk¹,

Pekcan

Güner

et al. 2014

Clinical Respiratory J

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Cited by 28 publications

References 170 publications

Experience in Treatment of Patients with Severe Influenza with Viral Pneumonia in ICU

Experience in Treatment of Patients with Severe Influenza with Viral Pneumonia in ICU

Prospective Cohort Study of the Safety of an Influenza A(H1N1) Vaccine in Pregnant Chinese Women

Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation

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