Efficacy of intravenous immunoglobulin treatment in immunocompromised children with <scp>H1N1</scp> influenza: a clinical observation

Göktürk, Bahar; Pekcan, Sevgi; Güner, Şükrü Nail; Artaç, Hasibe; Keleş, Sevgi; Kirac, Mine; Reisli, İsmail

doi:10.1111/crj.12209

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Unfortunately, knowledge of the therapeutic effect and the mechanism of IVIG against influenza has been limited, although some findings have been reported 7–10. Evaluation of the therapeutic effect of IVIG against influenza using an animal model has also been reported 11,12.…”

Section: Discussionmentioning

confidence: 99%

Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin

Onodera¹,

Urayama²,

Hirota³

et al. 2017

BTT

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Influenza viruses A/H1N1, A/H3N2, and B are known seasonal viruses that undergo annual mutation. Intravenous immunoglobulin (IVIG) contains anti-seasonal influenza virus globulins. Although the virus-neutralizing (VN) titer is an indicator of protective antibodies, changes in this titer over extended time periods have yet to be examined. In this study, variations in hemagglutination inhibition (HI) and VN titers against seasonal influenza viruses in IVIG lots over extended time periods were examined. In addition, the importance of monitoring the reactivity of IVIG against seasonal influenza viruses with varying antigenicity was evaluated. A/H1N1, A/H3N2, and B influenza virus strains and IVIG lots manufactured from 1999 to 2014 were examined. The HI titer was measured by standard methods. The VN titer was measured using a micro-focus method. IVIG exhibited significant HI and VN titers against all investigated strains. Our results suggest that the donor population maintains both specific and cross-reactive antibodies against seasonal influenza viruses, except in cases of pandemic viruses, despite major antigen changes. The titers against seasonal influenza vaccine strains, including past strains, were stable over short time periods but increased slowly over time.

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Section: Discussionmentioning

confidence: 99%

Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin

Onodera¹,

Urayama²,

Hirota³

et al. 2017

BTT

View full text Add to dashboard Cite

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“…Studies on the Efficacy of immunoglobulin therapy in influenza pneumonia have also been performed: In one study, NK cell activity as a marker of drug efficacy through antibody-dependent cellular cytotoxicity mechanism was used as a criterion that raised the possibility of treatment efficacy [105]. Another retrospective study found that IVIG administration to immunocompromised children with H1N1 had beneficial effects, including reduced mortality and hospitalization in the intensive care unit [106]. Moreover, a reliable role for IVIG in reducing the inflammatory response was found in a review study that examined the Efficacy of several immunomodulatory mechanisms on the severe form of influenza [107].…”

Section: Pentoxifyllinementioning

confidence: 99%

A Possible Guide as a Tool to Complementary Effects of New Coronavirus

Sadremomtaz¹,

Hashemi²,

Sahebnasagh³

et al. 2021

AACC

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At the end of 2019, Sars-CoV-2 was identified and has since spread in the world. Coronavirus is commonly caused by upper respiratory tract and severe acute respiratory syndrome in humans. Due to the novel nature of the virus and high mortality among high-risk people, today health care providers used several medications with different mechanisms to overcome this virus. The course of COVID-19 represents three stages that have different symptoms and used different drugs depends on each stage. Ultimately the minority of patients progress to stage III with high mortality. The aim of this study is a comprehensive review of COVID-19 adjuvant therapies. We explained the current study on the use of Glucocorticoids, Interferon, Vitamin C, Tocilizumab, Anakinra, Pentoxifylline, IVIG, Allopurinol, Ivermectin, and Selenium in sepsis, pneumonia, and ARDS and we suggested a new protocol for prescribing each medication currently used in COVID-19 Outbreak.

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Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology

Lilienfeld‐Toal

Berger

Christopeit

et al. 2016

European Journal of Cancer

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Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation

Cited by 4 publications

References 31 publications

Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin

Neutralizing activities against seasonal influenza viruses in human intravenous immunoglobulin

A Possible Guide as a Tool to Complementary Effects of New Coronavirus

Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology

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