Recommendations for the Use of Radiotherapy in Nodal Lymphoma

Hoskin, Peter; Díez, Patricia; Williams, Michael; Lucraft, H. H.; Bayne, Michael

doi:10.1016/j.clon.2012.07.011

Cited by 58 publications

(46 citation statements)

References 41 publications

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“…There is no consensus regarding a definition of anatomical boundaries for IFRT; the presented results may have differed slightly, for example with IFRT using smaller margins/omitting uninvolved hila. For the purposes of the study we utilised ISRT based on the UK guidelines [1]. It seems likely that similar results would have been obtained using the ILROG definition [2,3] which generates a margin based on clinical judgement of several factors.…”

Section: Discussionmentioning

confidence: 97%

“…ISRT was contoured according to the UK recommendations [1]. The CTV was defined as the pre-chemotherapy extent of involved lymph nodes with an expansion of 1.5 cm in the craniocaudal direction of lymphatic spread, modified within post-chemotherapy anatomical boundaries.…”

Section: Volume Definitions For Involved Site Radiotherapymentioning

confidence: 99%

“…In order to account for these difficulties, the UK National Cancer Research Institute (NCRI) Lymphoma Radiotherapy Group developed guidelines for a concept termed 'involved site radiotherapy' (ISRT) to address this issue [1]. This version of ISRT includes an additional margin of 1.5 cm craniocaudally in the direction of lymphatic spread from the pre-chemotherapy extent of nodal disease.…”

Section: Introductionmentioning

confidence: 99%

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Involved Node, Site, Field and Residual Volume Radiotherapy for Lymphoma: A Comparison of Organ at Risk Dosimetry and Second Malignancy Risks

et al. 2015

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Section: Discussionmentioning

confidence: 97%

Section: Volume Definitions For Involved Site Radiotherapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Involved Node, Site, Field and Residual Volume Radiotherapy for Lymphoma: A Comparison of Organ at Risk Dosimetry and Second Malignancy Risks

et al. 2015

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“…[1][2][3][4][5] For the early-stage Hodgkin lymphoma (HL) and Non-HL (NHL), the combined modality treatment (CMT) has shown higher patient survival and better local tumor control. 6,7 Staging is performed by physical examination, blood test, and tomographic imaging (usually computed tomography [CT] preferably coupled with [ 18 F]-fluorodeoxyglucose positron emission tomography [[ 18 F]FDG-PET]), which provides anatomical and metabolic information about the lymph nodes involved.…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy of Hodgkin and Non-Hodgkin Lymphoma

Zaffino

Ciardo

Piperno

et al. 2015

Technol Cancer Res Treat

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Purpose: To improve the contouring of clinical target volume for the radiotherapy of neck Hodgkin/non-Hodgkin lymphoma by localizing the prechemotherapy gross target volume onto the simulation computed tomography using [18 F]-fluorodeoxyglucose positron emission tomography/computed tomography. Material and Methods: The gross target volume delineated on prechemotherapy [18 F]-fluorodeoxyglucose positron emission tomography/computed tomography images was warped onto simulation computed tomography using deformable image registration. Fifteen patients with neck Hodgkin/non-Hodgkin lymphoma were analyzed. Quality of image registration was measured by computing the Dice similarity coefficient on warped organs at risk. Five radiation oncologists visually scored the localization of automatic gross target volume, ranking it from 1 (wrong) to 5 (excellent). Deformable registration was compared to rigid registration by computing the overlap index between the automatic gross target volume and the planned clinical target volume and quantifying the V 95 coverage. Results: The Dice similarity coefficient was 0.80 + 0.07 (median + quartiles). The physicians' survey had a median score equal to 4 (good). By comparing the rigid versus deformable registration, the overlap index increased from a factor of about 4 and the V 95 (percentage of volume receiving the 95% of the prescribed dose) went from 0.84 + 0.38 to 0.99 + 0.10 (median + quartiles). Conclusion: This study demonstrates the impact of using deformable registration between prechemotherapy [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography and simulation computed tomography, in order to automatically localize the gross target volume for radiotherapy treatment of patients with Hodgkin/non-Hodgkin lymphoma.

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“…Therefore, both the International Lymphoma Radiation Oncology Group and the UK National Cancer Research Institute have developed guidelines for volume delineation in this scenario. 18,19 Involved-site RT (ISRT) is similarly used to target the initially involved lymph nodes but allows for a potentially larger margin based on the uncertainty introduced by the lack of prechemotherapy imaging or inability to fuse such imaging. 18,19 Figure 1 illustrates how ISRT can substantially reduce the volume of tissue irradiated when compared with IFRT.…”

mentioning

confidence: 99%

Contemporary Radiation Therapy in Combined Modality Therapy for Hodgkin Lymphoma

Narang

Terezakis

2015

J Natl Compr Canc Netw

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The advent of effective combination chemotherapy markedly changed the management of Hodgkin lymphoma, establishing combined modality therapy as the standard of care for most patients with this disease. In response, significant interest has been shown in refining the delivery of radiation in the combined modality setting such that toxicity is minimized while still preserving disease control. An understanding of the way in which radiation treatment fields, prescription dose, and advanced technology have evolved to accomplish these goals is critical. Moreover, fluency in the clinical literature exploring contemporary questions, such as the omission of radiation and response-based treatment, is equally important. Knowledge of these topics will yield both an appreciation of the value of radiation in the combined modality setting and the ability to better customize treatment regimens to individual patients. (J Natl Compr Canc Netw 2015;13:597-605)

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Recommendations for the Use of Radiotherapy in Nodal Lymphoma

Cited by 58 publications

References 41 publications

Involved Node, Site, Field and Residual Volume Radiotherapy for Lymphoma: A Comparison of Organ at Risk Dosimetry and Second Malignancy Risks

Involved Node, Site, Field and Residual Volume Radiotherapy for Lymphoma: A Comparison of Organ at Risk Dosimetry and Second Malignancy Risks

Radiotherapy of Hodgkin and Non-Hodgkin Lymphoma

Contemporary Radiation Therapy in Combined Modality Therapy for Hodgkin Lymphoma

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