Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research

Guastella, Adam J.; Hickie, Ian B.; McGuinness, Margaret M.; Otis, Mélissa; Woods, Elizabeth A.; Disinger, Hannah M.; Chan, Hak‐Kim; Chen, Timothy; Bánati, Richard B.

doi:10.1016/j.psyneuen.2012.11.019

Cited by 323 publications

(276 citation statements)

References 92 publications

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“…Almost all of the studies testing emotion recognition in healthy samples have administered the standard dose of 24 IU. Systematic evaluation of how response changes according to dose and other measurable factors that influence bioavailability of nasal administration is required (Guastella et al, 2013). These changes should be evaluated in the context of a range of other variables thought to mark response to OT, such as heart rate variability (Kemp et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-four International Units is the most common dosage because of historical reasons; however, it is unclear whether other more optimal doses exist or whether someone who does not respond to lower doses will respond to higher ones (see Guastella et al, 2013) with respect to the latest recommendations relating to nasal spray administration).…”

Section: Types Of Interventionmentioning

confidence: 99%

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The Impact of a Single Administration of Intranasal Oxytocin on the Recognition of Basic Emotions in Humans: A Meta-Analysis

Shahrestani

Kemp

Guastella

2013

Neuropsychopharmacol

257

183

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Many studies have highlighted the potential of oxytocin (OT) to enhance facial affect recognition in healthy humans. However, inconsistencies have emerged with regard to the influence of OT on the recognition of specific emotional expressions (happy, angry, fear, surprise, disgust, and sadness). In this study, we conducted a meta-analysis of seven studies comprising 381 research participants (71 females) examining responses to the basic emotion types to assess whether OT enhances the recognition of emotion from human faces and whether this was influenced by the emotion expression and exposure time of the face. Results showed that intranasal OT administration enhances emotion recognition of faces overall, with a Hedges g effect size of 0.29. When analysis was restricted to facial expression types, significant effects of OT on recognition accuracy were specifically found for the recognition of happy and fear faces. We also found that effect sizes increased to moderate when exposure time of the photograph was restricted to early phase recognition (o300 ms) for happy and angry faces, or later phase recognition for fear faces (4300 ms). The results of the meta-analysis further suggest that OT has potential as a treatment to improve the recognition of emotion in faces, allowing individuals to improve their insight into the intentions, desires, and mental states of others.

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Section: Discussionmentioning

confidence: 99%

Section: Types Of Interventionmentioning

confidence: 99%

The Impact of a Single Administration of Intranasal Oxytocin on the Recognition of Basic Emotions in Humans: A Meta-Analysis

Shahrestani

Kemp

Guastella

2013

Neuropsychopharmacol

257

183

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“…53), elevated oxytocin in CSF is likely to reflect transnasal penetration into the CNS (4, 52), verifying that nebulization of oxytocin was successful. Unlike other routes of administration (e. g., intranasal, intravenous), nebulizing oxytocin may allow oxytocin molecules to be absorbed into the CNS through the nasal mucosa (54,55), making it one of the most effective routes of administration (50). Elevated oxytocin levels in both the CNS and periphery are most likely due to the direct effects of exogenous peptide administration, although it is impossible to rule out a contribution from endogenous oxytocin release (50).…”

Section: Discussionmentioning

confidence: 99%

Inhaled oxytocin increases positive social behaviors in newborn macaques

Simpson

Sclafani

Paukner

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Early caregiver-infant interactions are critical for infants' socioemotional and cognitive development. Several hormones and neuromodulators, including oxytocin, affect these interactions. Exogenous oxytocin promotes social behaviors in several species, including human and nonhuman primates. Although exogenous oxytocin increases social function in adults-including expression recognition and affiliation-it is unknown whether oxytocin can increase social interactions in infants. We hypothesized that nebulized oxytocin would increase affiliative social behaviors and such effects would be modulated by infants' social skills, measured earlier in development. We also hypothesized that oxytocin's effects on social behaviors may be due to its anxiolytic effects. We tested these hypotheses in a blind study by nebulizing 7-to 14-d-old macaques (n = 28) with oxytocin or saline. Following oxytocin administration, infants' facial gesturing at a human caregiver increased, and infants' salivary oxytocin was positively correlated with the time spent in close proximity to a caregiver. Infants' imitative skill (measured earlier in development: 1-7 d of age) predicted oxytocin-associated increases in affiliative behaviors-lip smacking, visual attention to a caregiver, and time in close proximity to a caregiver-suggesting that infants with higher propensities for positive social interactions are more sensitive to exogenous oxytocin. Oxytocin also decreased salivary cortisol, but not stressrelated behaviors (e.g., scratching), suggesting the possibility of some anxiolytic effects. To our knowledge, this study provides the first evidence that oxytocin increases positive social behaviors in newborns. This information is of critical importance for potential interventions aimed at ameliorating inadequate social behaviors in infants with higher likelihood of developing neurodevelopmental disorder.imitation recognition | neonatal imitation | individual differences

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“…In line with recommendations by Guastella et al (2013), the nasal spray was administered via a metered multi-dose pump spray bottle, with each spray containing no N 100 μL. Participants were given the opportunity to blow their nose prior to administration in order to clear the nasal passage if needed.…”

Section: Arrival and Nasal Spray Administrationmentioning

confidence: 99%

“…Intranasal administration has been proposed to deliver OT to the brain via uptake by the olfactory or trigeminal nerves and by passive diffusion into the cerebrospinal fluid through the nasal epithelium (for detailed reviews see Churchland and Winkielman, 2012;Guastella et al, 2013;Veening and Oliver, 2013). Intranasal OT has been demonstrated to lead to significant increases in CSF OT levels in humans as measured by lumbar puncture (Striepens et al, 2013), although it was only detectable 75 min after administration and there is controversy surrounding the nature and the mechanisms of the effects of OT administration on the brain (Leng and Ludwig, 2015).…”

Section: Arrival and Nasal Spray Administrationmentioning

confidence: 99%

Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance

Human

Thorson

Woolley

et al. 2017

Hormones and Behavior

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a b s t r a c t a r t i c l e i n f oIntranasal administration of the hypothalamic neuropeptide oxytocin (OT) has, in some studies, been associated with positive effects on social perception and cognition. Similarly, positive emotion inductions can improve a range of perceptual and performance-based behaviors. In this exploratory study, we examined how OT administration and positive emotion inductions interact in their associations with social and analytical performance. Participants (N = 124) were randomly assigned to receive an intranasal spray of OT (40 IU) or placebo and then viewed one of three videos designed to engender one of the following emotion states: social warmth, pride, or an affectively neutral state. Following the emotion induction, participants completed social perception and analytical tasks. There were no significant main effects of OT condition on social perception tasks, failing to replicate prior research, or on analytical performance. Further, OT condition and positive emotion inductions did not interact with each other in their associations with social perception performance. However, OT condition and positive emotion manipulations did significantly interact in their associations with analytical performance. Specifically, combining positive emotion inductions with OT administration was associated with worse analytical performance, with the pride induction no longer benefiting performance and the warmth induction resulting in worse performance. In sum, we found little evidence for main or interactive effects of OT on social perception but preliminary evidence that OT administration may impair analytical performance when paired with positive emotion inductions.

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Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research

Cited by 323 publications

References 92 publications

The Impact of a Single Administration of Intranasal Oxytocin on the Recognition of Basic Emotions in Humans: A Meta-Analysis

The Impact of a Single Administration of Intranasal Oxytocin on the Recognition of Basic Emotions in Humans: A Meta-Analysis

Inhaled oxytocin increases positive social behaviors in newborn macaques

Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance

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