Recommendation to test limonene hydroperoxides 0·3% and linalool hydroperoxides 1·0% in the British baseline patch test series

Abstract

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Allergic contact dermatitis caused by hydroperoxides of limonene and dose‐response relationship—A repeated open application test (ROAT) study

“…In recent years, Lim‐OOHs present in oxidized limonene have emerged as a very frequent cause of contact allergy in consecutively patch tested dermatitis patients . However, high proportions of weak positive and doubtful reactions have caused some concern regarding the clinical relevance of a positive patch test reaction .…”

The European baseline series and recommended additions: 2019

“…and limonene hydroperoxide 0.3% and 0.2% pet. have been widely tested and shown to produce frequent positive reactions, leading to recommendations to include them in some national series . It was highlighted that frequent irritant and doubtful patch test reactions to these haptens have been observed, and that, to aid in interpretation, two dilutions of each should be tested if these haptens are tested routinely.…”

Extended patch-test screening for fragrance contact allergy: findings and challenges

“…Therefore, their addition to the baseline series could probably be suggested, as favoured e.g. for the U.K . Ideally, the discussion on inclusion should consider clinical relevance of positive reactions, in particular, as at least some of the weak‐positive reactions (erythema and infiltration) may be irritant.…”