Allergic contact dermatitis caused by hydroperoxides of limonene and dose‐response relationship—A repeated open application test (ROAT) study

Bennike, Niels H.; Palangi, Lina; Christensson, Johanna Bråred; Nilsson, Ulrika; Zachariae, Claus; Johansen, Jeanne Duus; Hagvall, Lina

doi:10.1111/cod.13168

Cited by 37 publications

(48 citation statements)

References 35 publications

(67 reference statements)

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“…The proportion of positive reactions varies between 0 and 100%. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] Concentration, actually dose/cm², of the applied usage/ROAT preparation and length of application period are major reasons for the great variation. In the previous study on FM I based on the same material and design, positive ROAT reactions were obtained in 59% of those being hypersensitive to FM I and in 3% of those without contact allergy to FM I.…”

Section: Discussionmentioning

confidence: 99%

Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II: the EDEN Fragrance Study

Bruze

Engfeldt

Elsner

et al. 2021

Acad Dermatol Venereol

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Background In a European study on contact allergy in the general population, it has been hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure and thereafter subsequent avoidance of scented products implied a diagnosis of allergic contact dermatitis.Objectives The primary aim of this study was to validate this hypothesis/algorithm. The secondary aim was to investigate whether there was any association between the outcome of the recent repeated open application test (ROAT) and the patch test reactivity.Methods One hundred nine subjects with and without contact allergy to fragrance mix II (FM II) were recruited. Volunteers from six European dermatology clinics participated in the study including a patch test and a ROAT.Results Twenty-four positive ROAT reactions were noted in total including 20 of those 32 with contact allergy to FM II.None of the volunteers reacted to the vehicle (P < 0.001). More individuals with a positive algorithm had positive ROATs when compared with those with a negative algorithm. However, the difference was not statistically significant (P = 0.12).The lower the patch test concentration eliciting a positive test reaction, the more likely was a positive ROAT and the more likely that the positive ROAT appeared early during the investigative period. ConclusionsThe algorithm used in this study was not validated but it was indicated in this ROAT setup. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application period.

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Section: Discussionmentioning

confidence: 99%

Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II: the EDEN Fragrance Study

Bruze

Engfeldt

Elsner

et al. 2021

Acad Dermatol Venereol

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show abstract

“…When various usage tests including ROATs have been performed with fragrance sensitizers, positive reactions have been obtained in 0–100% of participants . Major reasons for the great variation are the concentration, the actual dose per cm 2 of the applied usage or ROAT preparation, and the length of the application period.…”

Section: Discussionmentioning

confidence: 99%

“…When various usage tests including ROATs have been performed with fragrance sensitizers, positive reactions have been obtained in 0-100% of participants. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Major reasons for the great variation are the concentration, the actual dose per cm 2 of the applied usage or ROAT preparation, and the length of the application period. In the present study, positive ROAT reactions were obtained in 59% of those hypersensitive to FM I and in 3% of those without contact allergy to FM I.…”

Section: Discussionmentioning

confidence: 99%

Validation of a questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix I

et al. 2019

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Summary Background In a European study on contact allergy in the general population, it was hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure, and thereafter subsequent avoidance of scented products, implied a diagnosis of allergic contact dermatitis. Objectives The primary aim of this study was to validate this hypothesis and algorithm. The secondary aim was to investigate whether there was any association between the outcome of the repeated open application test (ROAT) and the patch test reactivity. Methods In total, 109 patients with and without contact allergy to fragrance mix (FM) I were recruited. Volunteers from six European dermatology clinics participated in the study including a patch test and a ROAT. Results Positive ROAT reactions were noted in 26 of the 44 volunteers with contact allergy to FM I. None of the volunteers reacted to the vehicle (P < 0·001). More individuals with a positive algorithm had positive ROATs than those with a negative algorithm. However, the difference was not statistically significant. The lower the patch test concentration eliciting a positive test reaction, the more likely a positive ROAT and the more likely that the positive ROAT appeared early during the investigative period. Conclusions The algorithm used in this study was not substantiated in this ROAT set‐up. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application period. What's already known about this topic? To the best of our knowledge, a scientifically designed and conducted repeated open application test (ROAT) has never been performed before to validate a diagnosis of allergic contact dermatitis partly based on a questionnaire. What does this study add? This is the largest controlled, randomized and blinded ROAT performed to date. Higher patch test reactivity to fragrance mix I indicated a greater likelihood of a positive ROAT. What are the clinical implications of this work? Further refinement of the questions is required in order to diagnose allergic contact dermatitis from fragrances based on a questionnaire.

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“…Die Autoren gelangten zu der Schlussfolgerung, dass eine Kontaktallergie auf Lim-OOHs bei Patienten mit positiver und sogar bei einigen mit unklarer Epikutantestreaktion auf Lim-OOHs 0,3 % pet. klinisch relevant ist [74].…”

Section: Ergebnisseunclassified

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Uter¹,

Werfel

Lepoittevin

et al. 2021

Kompass Dermatol

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Kontaktallergie (Sensibilisierung) und daraus resultierende allergische Kontaktdermatitis (ACD) sind von erheblicher Tragweite aus Sicht des Gesundheitswesens. Für die vorliegende Übersichtsarbeit hierzu wurden alle passenden Artikel aus dem Zeitraum 2018–2019 per systematischer Suche in Medline und Web of Science<sup>TM</sup> ermittelt; außerdem wurden alle verfügbaren Ausgaben der Fachzeitschriften „Contact Dermatitis“ und „Dermatitis“ manuell durchsucht und so eine frühere, ähnliche Übersichtsarbeit fortgeschrieben und neu fokussiert. Neue Allergene ebenso wie bekannte Allergene, die in neuem Expositionskontext gefunden wurden oder deren Bedeutung in sonstiger Hinsicht neu bewertet wurde, werden in Abschnitten nach Substanzklasse gegliedert beschrieben (z. B. Metalle, Konservierungsmittel, Duftstoffe). Als gemeinsames Ergebnis zahlreicher Untersuchungen fällt sowohl ein Mangel an Informationen über die Produktzusammensetzung auf, z. B. in Bezug auf ein neu beschriebenes Allergen in Leinenturnschuhen (Dimethylthiocarbamylbenzothiazolsulfid), als auch vor allem die mangelnde Kooperativität von Herstellern von Blutzuckermessgeräten bzw. Insulinpumpen. Zu den letztgenannten Geräten hat eine internationale Zusammenarbeit zwischen Dermatologen und Chemikern gezeigt, dass sie bei zahlreichen Diabetikern schwere ACD verursachen, indem sie Isobornylacrylat bzw. N,N’-Dimethylacrylamid freisetzen. Eine verbesserte und vollständige Deklaration der Inhaltsstoffe für Produkte alle Art – und nicht nur, wie wir es derzeit in Europa haben, bei Kosmetika (abgesehen von der vollständigen Auflistung der Duftstoffe) – muss auf die legislative Agenda gesetzt werden.

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Allergic contact dermatitis caused by hydroperoxides of limonene and dose‐response relationship—A repeated open application test (ROAT) study

Cited by 37 publications

References 35 publications

Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II: the EDEN Fragrance Study

Validation of questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix II: the EDEN Fragrance Study

Validation of a questionnaire algorithm based on repeated open application testing with the constituents of fragrance mix I

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

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