Recombinant Glycosylated Human Inter-Leukin-6 Accelerates Peripheral Blood Platelet Count Recovery in Radiation Induced Bone Marrow Depression in Baboons and Modifies Several Biological Parameters

Hérodin, Françis; Mestries, J.C.; Janodet, D.; Martin, S E; Mathieu, Jacques; Gascon, Marie-Paule; Pernin, M O; Ythier, Arnaud

doi:10.1097/00002371-199301000-00026

Cited by 17 publications

(22 citation statements)

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“…The results of present study are in accordance with previous observations, which showed the ability of IL-6 to induce anaemia in different animal models and in humans [12,15]. Thus, a relationship between IL-6 and anaemia seems to be established.…”

Section: Discussionsupporting

confidence: 93%

“…Finally, sequestration of erythrocytes was mentioned as a possible explanation for IL-6 induced anaemia [12,15], whereas previously a shortened life span of erythrocytes was postulated to be involved in ACD [29]. No evidence for enhanced elimination of erythrocytes, from the circulation to the liver, was found after i.p.…”

Section: Discussionmentioning

confidence: 99%

“…Administration of IL-6 induced anaemia in experimental animals [12][13][14] and in humans [15,16]. The pathogenesis of this IL-6-induced anaemia has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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IL-6-induced anaemia in rats: possible pathogenetic implications for anaemia observed in chronic inflammations

Jongen‐Lavrencic

Peeters

Rozemuller

et al. 1996

Clinical and Experimental Immunology

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Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor‐alpha (TNF‐α), IL‐1 and Il‐6 as well as a relative deficiency of erythroprotein (EPO), are thought to play a key role. In the present study the role of IL‐6 in the pathogenesis of this anaemia was investigated. IL‐6 was administered intraperitoneally to rats for 14 sequential days. It appeared that IL‐6 was able to induce anaemia. No evidence for suppression of bone marrow erythropoiesis or enhanced sequestration of erythrocytes in the liver was found. However, decreased plasma and bone marrow iron contents were observed in anaemic rats. Blood loss in intestinal tissue was demonstrated using erythrocyte labelling with 99mtechnetium. Histologically this was associated with inflammatory cell infiltration, oedema and bleeding in the intestinal wall. In conclusion, IL‐6 induced anaemia in rats. This anaemia was caused by intestinal blood loss.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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IL-6-induced anaemia in rats: possible pathogenetic implications for anaemia observed in chronic inflammations

Jongen‐Lavrencic

Peeters

Rozemuller

et al. 1996

Clinical and Experimental Immunology

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“…An increase in the interleukin-6 levels was seen in the DADS pretreatment prior radiation groups when compared to the radiation control group. Interleukin-6 has been shown to play a key role in the induction of immune response and stimulation of haematopoiesis [32]. There is enhancement in the reduced glutathione levels (p<0.01) in the DADS pretreatment prior radiation groups compared to the radiation control group.…”

Section: Discussionmentioning

confidence: 95%

Haematopoietic, Antioxidant and Membrane Stabilizing Property of Diallyl Disulphide in Irradiated Mice

Tenkanidiyoor

Vasudeva

Rao

et al. 2016

JCDR

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“…In addition to the rhesus macaque, several studies have been conducted using baboons to evaluate radiation injuries as a result of X-irradiation (Mahmud et al 2004), 60 Co c-rays (Norol et al 2000), and mixed field exposure (Herodin et al 1992). Promising radiation countermeasures under development for H-ARS have been tested in NHP for efficacy and pharmacokinetics/ pharmacodynamics.…”

Section: Nhpmentioning

confidence: 99%

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

Singh

Seed²

2017

International Journal of Radiation Biology

140

103

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Purpose: The increasing global risk of nuclear and radiological accidents or attacks has driven renewed research interest in developing medical countermeasures to potentially injurious exposures to acute irradiation. Clinical symptoms and signs of a developing acute radiation injury, i.e. the acute radiation syndrome, are grouped into three sub-syndromes named after the dominant organ system affected, namely the hematopoietic, gastrointestinal, and neurovascular systems. The availability of safe and effective countermeasures against the above threats currently represents a significant unmet medical need. This is the first article within a three-part series covering the nature of the radiation subsyndromes, various animal models for radiation countermeasure development, and the agents currently approved by the United States Food and Drug Administration for countering the medical consequences of several of these prominent radiation exposure-associated syndromes. Conclusions: From the U.S. and global perspectives, biomedical research concerning medical countermeasure development is quite robust, largely due to increased government funding following the 9/11 incidence and subsequent rise of terrorist-associated threats. A wide spectrum of radiation countermeasures for specific types of radiation injuries is currently under investigation. However, only a few radiation countermeasures have been fully approved by regulatory agencies for human use during radiological/nuclear contingencies. Additional research effort, with additional funding, clearly will be needed in order to fill this significant, unmet medical health problem. ARTICLE HISTORY

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Recombinant Glycosylated Human Inter-Leukin-6 Accelerates Peripheral Blood Platelet Count Recovery in Radiation Induced Bone Marrow Depression in Baboons and Modifies Several Biological Parameters

Cited by 17 publications

References 0 publications

IL-6-induced anaemia in rats: possible pathogenetic implications for anaemia observed in chronic inflammations

IL-6-induced anaemia in rats: possible pathogenetic implications for anaemia observed in chronic inflammations

Haematopoietic, Antioxidant and Membrane Stabilizing Property of Diallyl Disulphide in Irradiated Mice

A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures

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