Haematopoietic, Antioxidant and Membrane Stabilizing Property of Diallyl Disulphide in Irradiated Mice

Tenkanidiyoor, Yogish Somayaji; Vasudeva, Vidya; Rao, Shama; Gowda, Damodara; Rao, Chandrika; Sanjeev, Ganesh; Nalilu, Suchetha Kumari

doi:10.7860/jcdr/2016/16371.7246

Cited by 5 publications

(11 citation statements)

References 25 publications

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“…DADS may induce 3-mercapopyruvate sulfurtransferase, leading to GSH production [17]. Conversely, DADS has also been reported to have no effect on radiation effects in the liver [87] and further evaluation will be needed in the future.…”

Section: Radiation Effects and Lifestyle-related Environmental Strmentioning

confidence: 99%

Radiation-Induced Reactions in the Liver—Modulation of Radiation Effects by Lifestyle-Related Factors—

Nakajima

Ninomiya

Nenoi³

2018

IJMS

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Radiation has a wide variety of effects on the liver. Fibrosis is a concern in medical fields as one of the acute effects of high-dose irradiation, such as with cancer radiotherapies. Cancer is also an important concern following exposure to radiation. The liver has an active metabolism and reacts to radiations. In addition, effects are modulated by many environmental factors, such as high-calorie foods or alcohol beverages. Adaptations to other environmental conditions could also influence the effects of radiation. Reactions to radiation may not be optimally regulated under conditions modulated by the environment, possibly leading to dysregulation, disease or cancer. Here, we introduce some reactions to ionizing radiation in the liver, as demonstrated primarily in animal experiments. In addition, modulation of radiation-induced effects in the liver due to factors such as obesity, alcohol drinking, or supplements derived from foods are reviewed. Perspectives on medical applications by modulations of radiation effects are also discussed.

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Section: Radiation Effects and Lifestyle-related Environmental Strmentioning

confidence: 99%

Radiation-Induced Reactions in the Liver—Modulation of Radiation Effects by Lifestyle-Related Factors—

Nakajima

Ninomiya

Nenoi³

2018

IJMS

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“…Radiation induces decreases in spleen weight early after irradiation [26,27]. We assessed the effects of radiation on spleen weight 1 week after irradiation and observed decreased spleen weights in irradiated mice (Figure 5A, 5C), showing that DADS had no effect on this decrease (Figure 5A).…”

Section: Resultsmentioning

confidence: 99%

“…There are several reports that sulfur compounds from garlic can protect against the acute effects of radiation [15,17,27]. DADS is a main component of sulfur-containing compounds in garlic oil; therefore, DADS might be effective in reducing DNA damage or persistent effects after irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of DADS on damage induced by electron beam irradiation were reported in a recent study [27] in which spleen weight changes and DNA damage were evaluated 24 h after irradiation with 6 Gy. The dose of X-rays used in our study was 4 Gy, which is much less than LD50/30 (5.9 Gy) in the case of BALB/c mice [30].…”

Section: Discussionmentioning

confidence: 99%

“…The dose used in the present study (4 Gy) is often used for evaluating DNA damage caused by radiation [31] and also within the range of doses administered to normal tissues during cancer radiotherapy [32]. In addition, although Tenkanidiyoor et al demonstrated the protective effects of DADS on spleen damage 24 h after irradiation [27], we primarily evaluated the effects in vivo 3 weeks after irradiation. Many researchers have demonstrated that high-dose radiation causes decreased spleen weight [26,27].…”

Section: Discussionmentioning

confidence: 99%

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Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation

et al. 2019

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BackgroundSeveral factors found in foods are beneficial to human health and they may contribute to radiation protection. Taking food factors could be an easy way to reduce the effects of radiation after nuclear accidents, as well as secondary radiation risks after cancer radiotherapy or space missions. Here, diallyl disulfide (DADS), a component of garlic oil, was studied for its ability to mitigate radiation damage.Material/MethodsWe investigated the effects of DADS on micronucleus (MN) formation and apoptosis in HepG2 cells by use of 4-Gy X-ray irradiation. We also assessed the effects of DADS on radiation damage in vivo by evaluating MN formation in bone marrow cells in mice (BALB/c, 8-week-old females) after oral intake of DADS prior to irradiation with 4 Gy. Several tissue effects were also investigated.ResultsThe presence of DADS inhibited MN formation, whereas DADS had no influence on the radiation-induced inhibition of cell cycle progression in HepG2 cells. An increase in apoptosis in HepG2 cells was induced after irradiation, and this effect was stronger in the presence of DADS than in its absence. In mice, when DADS was administered daily for 3 days prior to irradiation, MN formation in irradiated mice was decreased. The decrease in MN formation in mice was greater with 0.5% DADS compared to 1% DADS. Moreover, an increase in spleen weight observed 3 weeks after irradiation was suppressed in mice administered DADS.ConclusionsDADS is a potential radiation-protective agent that effectively mitigates DNA damage, and its effects in the spleen observed after irradiation may be related to inflammation and carcinogenesis.

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Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments

et al. 2022

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Haematopoietic, Antioxidant and Membrane Stabilizing Property of Diallyl Disulphide in Irradiated Mice

Cited by 5 publications

References 25 publications

Radiation-Induced Reactions in the Liver—Modulation of Radiation Effects by Lifestyle-Related Factors—

Radiation-Induced Reactions in the Liver—Modulation of Radiation Effects by Lifestyle-Related Factors—

Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation

Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments

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