2010
DOI: 10.1016/j.addr.2010.04.007
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Recombinant elastin-mimetic biomaterials: Emerging applications in medicine

Abstract: Biomaterials derived from protein-based block copolymers are increasingly investigated for potential application in medicine. In particular, recombinant elastin block copolymers provide significant opportunities to modulate material microstructure and can be processed in various forms, including particles, films, gels, and fiber networks. As a consequence, biological and mechanical responses of elastin-based biomaterials are tunable through precise control of block size and amino acid sequence. In this review,… Show more

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Cited by 83 publications
(73 citation statements)
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“…Recently, elastin-like polypeptide (ELP) has been used to fabricate hollow micro-spheres of a gene delivery depot [19]. ELP is used for various biomedical applications due to its biodegradable, non-toxic, noninflammatory properties and efficient pharmacokinetics for the delivery of therapeutics [20,21].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, elastin-like polypeptide (ELP) has been used to fabricate hollow micro-spheres of a gene delivery depot [19]. ELP is used for various biomedical applications due to its biodegradable, non-toxic, noninflammatory properties and efficient pharmacokinetics for the delivery of therapeutics [20,21].…”
Section: Introductionmentioning
confidence: 99%
“…25 The reader is directed to the following reviews for more details. 29,[149][150][151] These synthetic elastin matrices, oftentimes combined with synthetic collagen matrices, have been used to recapitulate features of the ECM in applications for tissue repair, [152][153][154][155][156] drug delivery, 29,157,158 and materials with tunable material properties. 150,154,[159][160][161] …”
Section: Collagen-mimetic Peptidesmentioning
confidence: 99%
“…17 Thermodynamic, entropic, and stereochemical factors guide non-covalent self-assembly of supramolecular structures that dictate mechanical and biological functionality. 3,[25][26][27] Ranging from alternating hydrophobic and hydrophilic amino acids that create facial ampiphiles [28][29][30] to Xxx-Yyy-Gly sequences that predispose a-helix formation, nature has evolved a set of rules that govern arrangement at the molecular, nano, micro, meso, and macroscales. [31][32][33] The rational design of fiber forming biologically inspired materials, requires an understanding of these interactions for directed molecular self-assembly.…”
Section: Introductionmentioning
confidence: 99%
“…Polypeptides such as collagen, elastin, and silk, are currently being sought as nextgeneration biomaterials (Table 2). [23][24][25][26][27][28] Collagen, a major constituent of bone, cartilage, tendon, skin and muscle, are the most abundant proteins in the human body. [29] Several different types of collagen have been identified; these proteins are distinguished by their triple-helical structure.…”
Section: Introductionmentioning
confidence: 99%