Recnotes. Volume R-96-1. August 1996,

Martin, Chester O.; Jackson, R. S.; Proffitt, Roy

doi:10.21236/ada316727

Cited by 4 publications

(10 citation statements)

References 0 publications

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“…An additional semiquantitative estimation of the population of ε Ϫ rotamers was done with the equation x ε Ϫ ϭ the isodesmic model. [53] In this model, the assumption is made that all the equilibrium constants for the N n ϩ N q N nϩ1 equilibria 4 J H2ЈP (expt)/2.3, [39] which showed that population of ε Ϫ rotamers is in the range from 30 to 35 percentage points. Ϫ The populations are equal.…”

mentioning

confidence: 99%

Multinuclear NMR Study of the Conformational Changes in MepdG and dGpMe upon Interaction with Mg2+, Zn2+ and Hg2+ Ions Reveals the Strengthening of the Anomeric Effect by Soft M2+ Ions

Polak

Plavec²

1999

Eur. J. Inorg. Chem.

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A conformational study is reported on 2′‐deoxyguanosine 5′‐methylmonophosphate [MepdG (1)] and 2′‐deoxyguanosine 3′‐methylmonophosphate [dGpMe (2)] and their interactions with Mg2+, Zn2+ and Hg2+ ions. The conformation of MepdG (1) and dGpMe (2) in D2O solution was inferred from vicinal proton‐proton, proton‐phosphorus and carbon‐phosphorus NMR coupling constants and nuclear Overhauser effects (NOE). The chemical shift changes showed that hard Mg2+ ions interact preferentially with the phosphate oxygen atoms in MepdG (1), whereas in the case of dGpMe (2) the interaction with the phosphate oxygen atoms competes with the interaction to the C6=O carbonyl group. Softer Zn2+ and Hg2+ ions were found to show strong binding affinity towards N7 in both MepdG (1) and dGpMe (2). Analysis of J coupling constants and NOEs measured as a function of metal ion concentration revealed that: (i) N → S pseudorotational equilibria are biased towards C2′‐endo pseudorotamers in M2+‐free MepdG (1) and dGpMe (2) by 68% and 75% at 298K, respectively. Titration of MepdG (1) and dGpMe (2) with Mg2+ ions caused no observable changes in N → S pseudorotational equilibrium, whereas the interactions of Zn2+ and Hg2+ ions with N7 resulted in the shift towards N‐type pseudorotamers which can be explained by the strengthening of the anomeric effect as softer metal ions bind to N7 and make the imidazole moiety less electron‐rich. (ii) The binding of divalent metal ions to MepdG (1) and dGpMe (2) causes a shift of the syn → anti equilibrium towards anti, which is larger for softer Zn2+ than for harder Mg2+ ions. (iii) The conformational equilibrium across the C4′–C5′ bond (γ torsion) in dGpMe (2) is not affected by the increased concentration of M2+ ions. (iv) βt conformers are preferred by ca. 77% in aqueous solution of MepdG (1) and only small changes of ca. 1 percentage point in βt population have been found upon metal ion binding to MepdG (1). (v) The two‐state ϵt → ϵ− conformational equilibrium is biased towards ϵt rotamers by 63.5% in dGpMe (2). Interaction of hard Mg2+ and softer Zn2+ or Hg2+ ions with dGpMe (2) resulted in the minor increase (< 3 percentage points) in the population of ϵt conformers.

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mentioning

confidence: 99%

Multinuclear NMR Study of the Conformational Changes in MepdG and dGpMe upon Interaction with Mg2+, Zn2+ and Hg2+ Ions Reveals the Strengthening of the Anomeric Effect by Soft M2+ Ions

Polak

Plavec²

1999

Eur. J. Inorg. Chem.

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“…In the present paper we are trying to predict the type of the singularity in the framework of the perturbative QCD. As in accordance with (59) λ 1 < g = 0.32 < 0.5, such an attempt at first glance does not look promising, as λ 1 is smaller than typical values obtained in phenomenological analysis [14][15][16]19] of existing experimental data. In the next paper we shall consider the contribution of non-perturbative effects to the ladder graph which contains double-logarithmic terms.…”

Section: Small-x Behaviour Of F Ns (X Q 2 )mentioning

confidence: 61%

“…A fit of deep inelastic scattering data itself gives different values for a. Indeed, fit R2 performed in [14] gives, for the unpolarized distributions, a u = 0.4 (for valence u-quarks) and a d = 0.76 (for valence d-quarks). The result of [15] is a u = 0.457, a d = 0.684.…”

Section: Small-x Behaviour Of F Ns (X Q 2 )mentioning

confidence: 99%

Analytical solution of the double-logarithmic integral equation with QCD running coupling

Manayenkov

1997

Zeitschrift f�r Physik C Particles and Fields

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“…2b. Also plotted are the gluon densities from the recent parton distribution sets MRS(R1) [10], CTEQ4M [11] and from GRV(HO) [12]. Whereas the agreement with MRS and CTEQ at low x is excellent, the steep gluon obtained from the dynamical evolution by GRV is inconsistent with the result of this analysis.…”

Section: Qcd Analysis Of Zeus 1994 Datamentioning

confidence: 85%