Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis

Fregni, Giulia; Quinodoz, Mathieu; Möller, Emely; Vuille, Joanna A.; Galland, Sabine; Fusco, Carlo; Martin, Patricia; Letovanec, Igor; Provero, Paolo; Rivolta, Carlo; Riggi, Nicolò; Stamenkovic, Ivan

doi:10.1016/j.ebiom.2018.02.017

Cited by 53 publications

(59 citation statements)

References 74 publications

(91 reference statements)

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“…In contradiction with this property, Fregni et al reported that the tumor microenvironment of MSCs implies some of the selected genes to overexpress and promotes metastasis in the case of lung cancer-derived MSCs. Here, the overexpressed genes were found out to be tumor-initiating markers and progressive towards metastasis [146]. MSCs can be miscreant due to their immune-microenvironment modulatory property, one recent example was the study of MSCs residing in the tumor microenvironment, where they developed therapy resistance in tumor cells [147].…”

Section: Outcome Of Modified Mscs: Positive and Negative Aspectsmentioning

confidence: 99%

Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Mishra

Shih

Parveen

et al. 2020

Cells

109

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The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due to their immense potential for immunosuppression and their therapeutic role in immune disorders. MSCs migrate towards inflamed microenvironments, produce anti-inflammatory cytokines and conceal themselves from the innate immune system. These signatures are the reason for the uprising in the sciences of cellular therapy in the last decades. Irrespective of their therapeutic role in immune disorders, some factors limit beneficial effects such as inconsistency of cell characteristics, erratic protocols, deviating dosages, and diverse transfusion patterns. Conclusive protocols for cell culture, differentiation, expansion, and cryopreservation of MSCs are of the utmost importance for a better understanding of MSCs in therapeutic applications. In this review, we address the immunomodulatory properties and immunosuppressive actions of MSCs. Also, we sum up the results of the enhancement, utilization, and therapeutic responses of MSCs in treating inflammatory diseases, metabolic disorders and diabetes.

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Section: Outcome Of Modified Mscs: Positive and Negative Aspectsmentioning

confidence: 99%

Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Mishra

Shih

Parveen

et al. 2020

Cells

109

View full text Add to dashboard Cite

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“…Hitherto, the cellular and molecular mechanisms of MSC transition from BM-MSCs to tumor-derived MSCs have not been clearly elucidated. Accumulating evidences have indicated that cancer cells or their conditioned medium could induce the activation of MSCs to assume a tumor-promoting phenotype ( 65 , 66 ). Moreover, tumor-educated neutrophils were also reported to induce the transformation of MSCs into cancer-associated fibroblasts (CAFs), which in turn remarkably facilitated the growth and metastasis of gastric cancer ( 67 ).…”

Section: Tam-triggered Transition Of Mscs In Gastric Cancermentioning

confidence: 99%

Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer

Zheng

2020

Front. Oncol.

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Tumor microenvironment (TME) consisting of distinct cell types including stromal cells and immune cells has recently emerged as a pivotal player in tumor development and progression. Mesenchymal stromal cells (MSCs) and tumor-associated macrophages (TAMs) are two representative cells in the TME with plastic properties. This review will focus on the evolution of phenotypes and functions of either MSCs or TAMs, which is “educated” by the TME, as well as interactions between MSCs and TAMs contributing to the distinct stages of tumor biology in gastric cancer. MSCs exert immunoregulatory effects on macrophages and polarize them toward M2-like TAMs, via cell–cell contact and paracrine or extracellular vesicle (EV) transfer mechanism. In turn, M2-TAMs modulate the transition of “naive” MSCs into tumor-derived MSCs, which possess a more potent pro-tumor role than the parent. Moreover, the cross talk between MSCs and TAMs could contribute to cancer biology by inducing the EMT process, metastasis, immune invasion, and immunotherapy resistance in cancer cells. However, molecular mechanisms underlying interactions between MSCs and TAMs in gastric cancer progression need to be thoroughly elucidated, which may provide attractive targets for making promising novel strategies for gastric cancer therapy.

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“…To study the role of MSC on cancer development and progression, several animal models has been developed, mainly xenograft and syngenic small rodents, with MSC co-injected with tumour cells (51–53). In these models, MSC participate to tumour pathophysiology, ultimately facilitating the metastatic spread of weakly metastatic cancer (52, 54–56). MSC/tumour cells ratio seems to be particularly relevant like for tumour dormancy/growth, as demonstrated in melanoma or osteosarcoma models (57, 58).…”

Section: In Vivo Modelsmentioning

confidence: 99%

Pre-clinical Models for Studying the Interaction Between Mesenchymal Stromal Cells and Cancer Cells and the Induction of Stemness

et al. 2019

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Mesenchymal stromal cells (MSC) have essential functions in building and supporting the tumour microenvironment, providing metastatic niches, and maintaining cancer hallmarks, and it is increasingly evident that the study of the role of MSC in cancer is crucial for paving the way to clinical opportunities for novel anti-cancer therapies. To date, the vast majority of preclinical models that have been used for studying the effect of reactive MSC on cancer growth, metastasis, and response to therapy has been mainly based on in vitro flat biology, including the co-culturing with cell compartmentalization or with cell-to-cell contact, and on in vivo cancer models with different routes of MSC inoculation. More complex in vitro 3D models based on spheroid structures that are formed by intermingled MSC and tumour cells are also capturing the interest in cancer research. These are innovative culture systems tailored on the specific tumour type and that can be combined with a synthetic extracellular matrix, or included in in silico technologies, to more properly mimic the in vivo biological, spatial, biochemical, and biophysical features of tumour tissues. In this review, we summarized the most popular and currently available preclinical models for evaluating the role of MSC in cancer and their specific suitability, for example, in assaying the MSC-driven induction of epithelial-to-mesenchymal transition or of stem-like traits in cancer cells. Finally, we enlightened the need to carefully consider those parameters that might unintentionally strongly affect the secretome in MSC-cancer interplay and introduce confounding variables for the interpretation of results.

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Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis

Cited by 53 publications

References 74 publications

Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Crosstalk Between Mesenchymal Stromal Cells and Tumor-Associated Macrophages in Gastric Cancer

Pre-clinical Models for Studying the Interaction Between Mesenchymal Stromal Cells and Cancer Cells and the Induction of Stemness

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