Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Abstract

The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due to their immense potential for immunosuppression and their therapeutic role in immune disorders. MSCs migrate towards inflamed microenvironments, produce anti-inflammatory cytokines and conceal themselves from the innate immune system. These signatures are the reason for the uprising in the sciences of cellular therapy in the last decades. Irrespective of their therapeutic role in immune disorders, some factors limit beneficial effects such as inconsistency of cell characteristics, erratic protocols, deviating dosages, and diverse transfusion patterns. Conclusive protocols for cell culture, differentiation, expansion, and cryopreservation of MSCs are of the utmost importance for a better understanding of MSCs in therapeutic applications. In this review, we address the immunomodulatory properties and immunosuppressive actions of MSCs. Also, we sum up the results of the enhancement, utilization, and therapeutic responses of MSCs in treating inflammatory diseases, metabolic disorders and diabetes.

Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury

“…The HS injury model rats were divided into control (HS) and study (HS + MSCs) groups (n=40 per group). After the model was established successfully, 2x10 6 MSCs suspended in 0.3 ml of saline were injected into the HS+MSCs group and 0.3 ml of saline were injected into the HS group via the tail vein. Rats in the HS and HS + MSCs groups were further divided into early (day 1), intermediate (days 7 and 14) and late (day 28) groups (n=10 per group).…”

“…Mesenchymal stem cells (MSCs) serve a number of roles, including enhancing angiogenesis and neurogenesis by secreting nutrient factors, regulating the immune system and exhibiting anti-inflammatory effects (5). MSCs may exhibit immunomodulatory effects, which are based on the mechanisms cell contact and paracrine signaling, and involve the release of soluble inflammatory factors (6). In particular, MSCs have been indicated to stimulate immune regulatory Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury factors, including interleukin (IL)-6, IL-10, prostaglandins, transforming growth factor-β (TGF-β) and nitric oxide (7).…”

Inactivated Platelet Lysate Supports the Proliferation and Immunomodulant Characteristics of Mesenchymal Stromal Cells in GMP Culture Conditions

“…Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from a variety of tissues, capable of producing significant factors including multiple cytokines and growth factors. In recent years, their peculiar immunomodulatory characteristics, mediated by the release of a plethora of trophic factors in their secretome, have been considered as having more than their multilineage differentiation potential for their clinical use in severe disease clinical trials, namely: autoimmune, chronic inflammatory, and degenerative conditions [ 1 , 2 ].…”

Inactivated Platelet Lysate Supports Proliferation and Immunomodulant Characteristics Of Mesenchymal Stromal Cells in GMP Culture Condition

“…Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from a variety of tissues, capable of producing important factors including multiple cytokines and growth factors. In the last years their peculiar immunomodulant characteristics, mediated by the release of a plethora of trophic factors in their secretome, have been considered more than their multilineage differentiation potential for their clinical use in clinical trials in severe disease: autoimmune, chronic inflammatory and degenerative conditions [1,2].…”