2002
DOI: 10.1084/jem.20012135
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Abstract: Chronic airway rejection is characterized by prolonged inflammation, epithelial damage, and eventual luminal obliterative bronchiolitis (OB). In cardiac allografts, the inducible nitric oxide synthase (iNOS) promotes acute rejection but paradoxically reduces neointimal formation, the hallmark of chronic rejection. The specific roles of NOS isoforms in modulating lymphocyte traffic and airway rejection are not known. Using a double lumen mouse tracheal transplant model, tracheal grafts from B10.A (allo) or C57B… Show more

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Cited by 28 publications
(34 citation statements)
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“…However, like IFN-γ, the role of iNOS in allograft acceptance is probably complex and diverse. For example, pharmacologic inhibition of iNOS and iNOS deficiency in upper airway transplant recipients was actually protective (36), and blocking iNOS prevented injury in a preclinical liver transplant model (37). Once again, the unique site-specific physiology of the lung transplant may explain differences in results among the study by Krupnick and colleagues and studies in other organ transplant models.…”
Section: Resultscontrasting
confidence: 41%
“…However, like IFN-γ, the role of iNOS in allograft acceptance is probably complex and diverse. For example, pharmacologic inhibition of iNOS and iNOS deficiency in upper airway transplant recipients was actually protective (36), and blocking iNOS prevented injury in a preclinical liver transplant model (37). Once again, the unique site-specific physiology of the lung transplant may explain differences in results among the study by Krupnick and colleagues and studies in other organ transplant models.…”
Section: Resultscontrasting
confidence: 41%
“…Tracheal isografts (BALB/c into BALB/c) maintained their normal architecture and demonstrated no significant Figure 3, C and D) secondary to characteristic thickening of the epithelial and subepithelial layer. 28,29 To study the role of IL-13, C57Bl/6 tracheas were transplanted into allogeneic IL-13 Ϫ/Ϫ recipients. These experiments showed a significant decrease in luminal occlusion in allografts transplanted into IL-13…”
Section: Role For Il-13 In Orthotopic Tracheal Transplantsmentioning
confidence: 99%
“…The first model was the previously described double lumen airway (orthotopic) transplant model for studying chronic airway rejection. 28,29 Briefly, after anesthesia, donor mice were exsanguinated, and whole trachea was harvested by transecting below the cricoid cartilage distal to the carinal bifurcation under sterile conditions. Recipient mice were similarly anesthetized, and the whole trachea was exposed.…”
Section: Tracheal Transplant Modelsmentioning
confidence: 99%
“…Recently, the orthotopic tracheal transplantation (OTT) model has been developed by some groups in which the donor trachea is directly anastamosed to recipient trachea (16,17). The OTT model is distinguished from HTTs in several ways.…”
mentioning
confidence: 99%